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Author: Per Lundahl
Publisher: Routledge
ISBN: 1317836537
Category : Science
Languages : en
Pages : 252
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Book Description
First published in 2004, this book collects several up-to-date methods for quantitative analysis of biospecific interactions, a field that has a long history that perhaps can be said to have begun with the classical paper of G. Scatchard in 1949 (The attractions of proteins for small molecules and ions, but which has advanced impressively during the last few years. A precise spatial arrangement of just a few hydrogen bonds can confer a remarkably specific reversible association between two molecules. A web of weak interactions governs biospecific recognition in general. The binding equilibria in living cells tune and coordinate a multitude of functions. The thermodynamic properties of such interactions are often studied by binding experiments in simplified and essentially ideal systems. However, similar types of studies may elucidate the biologically relevant dynamic steady-state conditions in living cells and organisms, allowing for the very wide range of interactant concentrations and the interplay between the many reactions and interactions. The development in biosciences will continue with in-depth studies of macromolecules and membranes. More detailed knowledge will allow analyses of delicate balances between substances and events in the complex systems involved in life processes. Methods to study biospecific affinities are thus highly important tools for understanding mechanisms and effects of molecular binding events in vivo and in vitro, e.g., in biochemical, biomedical and pharmaceutical research, and for biotechnological research and production.
Author: Per Lundahl
Publisher: Routledge
ISBN: 1317836537
Category : Science
Languages : en
Pages : 252
Get Book Here
Book Description
First published in 2004, this book collects several up-to-date methods for quantitative analysis of biospecific interactions, a field that has a long history that perhaps can be said to have begun with the classical paper of G. Scatchard in 1949 (The attractions of proteins for small molecules and ions, but which has advanced impressively during the last few years. A precise spatial arrangement of just a few hydrogen bonds can confer a remarkably specific reversible association between two molecules. A web of weak interactions governs biospecific recognition in general. The binding equilibria in living cells tune and coordinate a multitude of functions. The thermodynamic properties of such interactions are often studied by binding experiments in simplified and essentially ideal systems. However, similar types of studies may elucidate the biologically relevant dynamic steady-state conditions in living cells and organisms, allowing for the very wide range of interactant concentrations and the interplay between the many reactions and interactions. The development in biosciences will continue with in-depth studies of macromolecules and membranes. More detailed knowledge will allow analyses of delicate balances between substances and events in the complex systems involved in life processes. Methods to study biospecific affinities are thus highly important tools for understanding mechanisms and effects of molecular binding events in vivo and in vitro, e.g., in biochemical, biomedical and pharmaceutical research, and for biotechnological research and production.
Author: Peter Brust
Publisher: MDPI
ISBN: 3038971626
Category : Science
Languages : en
Pages : 218
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Book Description
This book is a printed edition of the Special Issue "Current Aspects of Radiopharmaceutical Chemistry" that was published in Molecules
Author: Colleen Croniger
Publisher: BoD – Books on Demand
ISBN: 9533073632
Category : Medical
Languages : en
Pages : 426
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Book Description
Obesity and type 2 diabetes are increasing worldwide problems. In this book we reviewed insulin secretion in both healthy individuals and in patients with type 2 diabetes. Because of the risk associated with progression from insulin resistance to diabetes and cardiovascular complications increases along a continuum, we included several chapters on the damage of endothelial cells in type 2 diabetes and genetic influences on endothelial cell dysfunction. Cardiovascular complications occur at a much lower glucose levels, thus a review on the oral glucose tolerance test compared to other methods was included. The medical conditions associated with type 2 diabetes such as pancreatic cancer, sarcopenia and sleep disordered breathing with diabetes were also discussed. The book concludes with several chapters on the treatments for this disease offering us hope in prevention and successful alleviation of the co-morbidities associated with obesity and type 2 diabetes.
Author: Richard B. Eckert
Publisher: CRC Press
ISBN: 1000470091
Category : Technology & Engineering
Languages : en
Pages : 517
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Book Description
Failure Analysis of Microbiologically Influenced Corrosion serves as a complete guide to corrosion failure analysis with an emphasis on the diagnosis of microbiologically influenced corrosion (MIC). By applying the principles of chemistry, microbiology, and metallurgy, readers will be able to reliably determine the mechanistic cause of corrosion damage and failures and select the appropriate methods for mitigating future corrosion incidents. FEATURES Provides background information on the forensic process, types of data or evidence needed to perform the analysis, industrial case studies, details on the MIC failure analysis process, and protocols for field and lab use Presents up-to-date advances in molecular technologies and their application to corrosion failure investigations Offers specific guidelines for conducting MIC failure analyses and case studies to illustrate their application Examines state-of-the-art information on MIC analytical tools and methods With authors with expertise in microbiology, corrosion, materials, and failure investigation, this book provides tools for engineers, scientists, and technologists to successfully combat MIC issues.
Author: Christophe Lacroix
Publisher: Frontiers Media SA
ISBN: 2889458687
Category :
Languages : en
Pages : 184
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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author: P. Michael Conn
Publisher: Academic Press
ISBN: 012385928X
Category : Cell physiology
Languages : en
Pages : 466
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Book Description
This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights. This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights
Author: Talitha Best
Publisher: CRC Press
ISBN: 1040059996
Category : Medical
Languages : en
Pages : 270
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Book Description
Public awareness of the role diet plays in brain function has been steadily increasing. This has led to significant development of new products, dietary supplements, functional foods, nutraceuticals and public health recommendations for maintaining brain function. Nutrition for Brain Health and Cognitive Performance presents a detailed and innovati
Author: John Fulcher
Publisher: Springer
ISBN: 3540782931
Category : Technology & Engineering
Languages : en
Pages : 1182
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Book Description
Computational Intelligence: A Compendium presents a well structured overview about this rapidly growing field with contributions from leading experts in Computational Intelligence. The main focus of the compendium is on applied methods, tried-and-proven as being effective to realworld problems, which is especially useful for practitioners, researchers, students and also newcomers to the field. This state-of- handbook-style book has contributions by leading experts.
Author: Laura M. Roa Romero
Publisher: Springer Science & Business Media
ISBN: 3319008463
Category : Technology & Engineering
Languages : en
Pages : 1978
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Book Description
The general theme of MEDICON 2013 is "Research and Development of Technology for Sustainable Healthcare". This decade is being characterized by the appearance and use of emergent technologies under development. This situation has produced a tremendous impact on Medicine and Biology from which it is expected an unparalleled evolution in these disciplines towards novel concept and practices. The consequence will be a significant improvement in health care and well-fare, i.e. the shift from a reactive medicine to a preventive medicine. This shift implies that the citizen will play an important role in the healthcare delivery process, what requires a comprehensive and personalized assistance. In this context, society will meet emerging media, incorporated to all objects, capable of providing a seamless, adaptive, anticipatory, unobtrusive and pervasive assistance. The challenge will be to remove current barriers related to the lack of knowledge required to produce new opportunities for all the society, while new paradigms are created for this inclusive society to be socially and economically sustainable, and respectful with the environment. In this way, these proceedings focus on the convergence of biomedical engineering topics ranging from formalized theory through experimental science and technological development to practical clinical applications.
Author: Atsushi Okawa
Publisher: Springer Nature
ISBN: 9811538557
Category : Medical
Languages : en
Pages : 272
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Book Description
This publication brings together information on all aspects of OPLL - epidemiology, etiology, diagnosis, and treatment. It contains contributions by Japanese researchers and surgeons, including members of the Ministry of Health and Welfare Investigation Committee, and by American surgeons with expertise in the field. Until now, little has been published on the subject in English. This collection of reports is amply augmented with illustrations.
