Protein Tyrosine Phosphatases in Tumor Progression and Metastasis PDF Download

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Protein Tyrosine Phosphatases in Tumor Progression and Metastasis

Protein Tyrosine Phosphatases in Tumor Progression and Metastasis PDF Author: Carmen Ferreira
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 0

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Book Description
Reversible phosphorylation of proteins, executed by kinases and phosphatases, is the major posttranslational protein modification in eukaryotic cells, causing them to become activated or deactivated. This intracellular event represents a critical regulatory mechanism of several signaling pathways and can be related to a broad number of diseases, including cancer. Few decades ago, protein tyrosine phosphatases (PTPs) were considered as tumor suppressors. However, nowadays, accumulating evidence demonstrates that a misregulation of PTP activities plays a crucial and decisive role in cancer progression and metastasis. In this chapter, we will focus on the molecular aspects that support the crucial role of PTPs in cancer and in turn make them promising for prediction, monitoring, and rational appropriate therapy selection of individual patients.