Protein Misfolding Diseases PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Protein Misfolding Diseases PDF full book. Access full book title Protein Misfolding Diseases by Marina Ramirez-Alvarado. Download full books in PDF and EPUB format.
Author: Marina Ramirez-Alvarado
Publisher: John Wiley & Sons
ISBN: 1118031814
Category : Science
Languages : en
Pages : 1311
Get Book Here
Book Description
An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease.
Author: Marina Ramirez-Alvarado
Publisher: John Wiley & Sons
ISBN: 1118031814
Category : Science
Languages : en
Pages : 1311
Get Book Here
Book Description
An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease.
Author: Lukas K. Tamm
Publisher: John Wiley & Sons
ISBN: 3527606998
Category : Science
Languages : en
Pages : 470
Get Book Here
Book Description
In 17 contributions by leading research groups, this first comprehensive handbook in the field covers the interactions between proteins and lipids that make the fabric of biological membranes from every angle. It examines the relevant hermodynamic and structural issues from a basic science perspective, and goes on to discuss biochemical and cell biological processes. The book covers physical principles as well as mechanisms of membrane fusion and fission. Additionally, chapters on bilayer structure and protein-lipid interactions as well as on how proteins shape lipids and vice versa, membrane penetration by toxins, protein sorting, and allosteric regulation of signal transduction across membranes make this a valuable information source for researchers in academia and industry.
Author: Peter Csermely
Publisher: Springer Science & Business Media
ISBN: 0387399755
Category : Science
Languages : en
Pages : 218
Get Book Here
Book Description
This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.
Author: Reinhard Schweitzer-Stenner
Publisher: Elsevier
ISBN: 0443159653
Category : Science
Languages : en
Pages : 328
Get Book Here
Book Description
The Physics of Protein Structure and Dynamics looks at various aspects of protein structure and dynamics from a physico-chemical point of view. It goes into some depth regarding the description of non-covalent forces that determine the relative stability of folded and unfolded proteins. Anharmonic protein dynamics involving motions between different minima of a rugged Gibbs energy landscape is described in great detail. The book combines various aspects of the protein folding/unfolding processes with an overview of intrinsically disordered proteins, which have attracted considerable interest of the protein community over the last 25 years but are thus far underrepresented in classroom-oriented textbooks. The book looks at protein folding and intrinsically disordered proteins as heavily interrelated topics that need to be viewed together. Furthermore, it presents some basic physico-chemical aspects of protein/peptide self-assembly into nanoscale fibrils. Intrinsically disordered peptides and proteins play a major role particularly in aggregation and self-assembly processes that lead to various diseases (Alzheimer, Parkinson, Huntington, Mad-Cow). Therefore, the relevance of protein disorder for protein self-assembly deserves a closer look. Protein self-assembly cannot be separated from protein folding since it is frequently the product of misfolding. With regard to modern theories, the folding processes are linked to insights on protein dynamics and the discovered relationship between proteins and spin glasses. - The readers will benefit from being provided with an in-depth overview of the physical concepts that govern different aspects of protein folding, disorder and self-assembly. By emphasizing the relationship between these issues, the approach adds a holistic character to the book - The book is to a major extent mathematically based. Mathematics is part of the language of physicists and physical chemists which cannot be properly substituted by words - For instructors, the book will offer a unique source for her/his teaching of current protein physics issues - The way how the book will be constructed (multiple references to primary literature with DOI links, literature-based problem sets and topics for discussion) will facilitate a learning process suitable for research-oriented students - Problem solving frequently requires the writing of short computer programs, something that is underemphasized in chemistry and biochemistry education (with the exception of computationally trained students, of course)
Author: Timir Tripathi
Publisher: Elsevier
ISBN: 0443218102
Category : Science
Languages : en
Pages : 1162
Get Book Here
Book Description
The Three Functional States of Proteins explores how structured proteins, intrinsically disordered proteins, and phase separated proteins contribute to the complexity of cellular life, and offers insights into their roles in both health and disease. It discusses the latest research findings and highlight groundbreaking discoveries and innovative methodologies used to study these protein states. Traditionally, the different states of proteins have been defined based on their structures and functions. However, it is becoming increasingly clear that these criteria alone may not be sufficient to capture the complex and multifaceted properties of these molecules. Definitions based on thermodynamics and kinetics are now recognized as potentially more appropriate for comprehensively understanding protein states. Emerging evidence indicates that under physiological conditions, a majority of proteins possess the capability to exist in and transition between the native, droplet, and amyloid states. These distinct states play crucial roles in various cellular functions, influenced significantly by their physicochemical and structural properties. The book also considers the interactions among these states and discusses how their internal organization as individual molecules, as well as their collective organization as molecular assemblies are stabilized. Furthermore, it examines the processes by which these states are formed and the cellular functions associated with each specific state. - The book serves as an introduction to a unique volume that provides comprehensive coverage of these three functional states of proteins - The chapters are written by leading global scientists who are actively engaged in research on these specific protein states - It presents a broad picture of the current, emerging, and evolving research on these protein states - Given that this book comprehensively addresses both foundational concepts and recent advancements in the field, it will appeal a broad spectrum of readers from various academic disciplines
Author: P. Michael Conn
Publisher: Academic Press
ISBN: 0080923399
Category : Science
Languages : en
Pages : 301
Get Book Here
Book Description
Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume. Follow the new editor-in-chief, P. Michael Conn, as he introduces this second thematic volume in the series – an in-depth aid to researchers who are looking for the best techniques and tools for understanding the complexities of protein folding Understand the advantages of protein folding over other therapeutic approaches and see how protein folding plays a critical role in the development of diseases such as Alzheimer’s and diabetes Decipher the rules of protein folding through compelling and timely reviews combined with chapters written by international authors in engineering, biochemistry, physics and computer science
Author:
Publisher: Elsevier
ISBN: 0080496679
Category : Science
Languages : en
Pages : 861
Get Book Here
Book Description
This volume includes a core of methodologies to attack the unique experimental problems presented by protein misassembly. Emphasis is on human biology applications, the area in which there is the most interest, in which most of the work has already been done, and in which there is the best evidence for the structural sophisitication of the protein aggregates.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Author: Stuart Keith Calderwood
Publisher: Frontiers Media SA
ISBN: 2889451526
Category :
Languages : en
Pages : 94
Get Book Here
Book Description
Heat shock proteins (HSPs) were discovered as polypeptides induced by stress that can be found in all kingdoms of cellular organisms. Their functions were, a first enigmatic and these proteins were thus classified by molecular weight, as in—Hsp27, Hsp70, Hsp90, Hsp110. More recently, each of these size-classified molecules has attributed a role in protein folding, and they thus came to be known, as a class, as molecular chaperones. However, the they possess properties beyond chaperoning. Indeed, their discovery in the extracellular spaces suggested roles in regulation of the immune responses.
Author: M Michael Gromiha
Publisher: World Scientific
ISBN: 9811293279
Category : Science
Languages : en
Pages : 396
Get Book Here
Book Description
Proteins perform various functions in living organisms. However, any mutation in the amino acid residues of a protein affects its structure and function. Some of these mutations may lead to diseases. These disease-causing mutations have an impact on protein structure, stability, and its binding affinity to complexes. Moreover, the study of amino acid mutation in proteins is important for developing therapeutic strategies. It is a pertinent and timely endeavor to provide comprehensive insights on the consequences of these mutations.The main highlights of this book are the effects of protein mutations on its various functions such as aggregation, folding, stability, binding affinity, and diseases, as well as a wide range of applications such as database development, computational algorithms, and drug design. It will be a platform to provide the up-to-date information and latest developments in the field and will serve as a single resource to get the information on comparative studies to delineate these mutational effects on protein folding, stability, and interactions, and for understanding the molecular basis of diseases.
Author: Kursad Turksen
Publisher: Springer Nature
ISBN: 3031284208
Category : Science
Languages : en
Pages : 196
Get Book Here
Book Description
Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 19th volume of a continuing series.
