Protein and Peptide-based Microarrays for Multiplex Detection PDF Download
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Author: Navid Rabiee
Publisher: IOP Publishing Limited
ISBN: 9780750336659
Category : Science
Languages : en
Pages : 70
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Book Description
Protein and Peptide-based Microarrays for Multiplex Detection looks at the aspects of protein and peptide-based microarrays for multiplex detection, based on Rabiee's Theory. A comprehensive guide for scientists, students and doctors.
Author: Hamblin RABIEE
Publisher:
ISBN: 9780750336680
Category :
Languages : en
Pages :
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Book Description
Author: Navid Rabiee
Publisher:
ISBN: 9780750336666
Category : SCIENCE
Languages : en
Pages :
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Book Description
This book discusses the aspects of protein and peptide-based microarrays for multiplex detection, based on Rabiee's Theory. It provides a thorough introduction to the field, before examining protein and peptide-based microarrays in greater detail, along with their related problems and solutions. Also covered are the materials and fabrication methods involved with protein microarrays. It offers an outlook on the future of the field within its conclusion and provides an understanding of cutting-edge aspects and horizons of this topic and is an excellent guide for scientists, students and doctors.
Author: Marina Cretich
Publisher: Humana
ISBN: 9781071627310
Category : Science
Languages : en
Pages : 0
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Book Description
This detailed volume provides an updated overview of current uses of peptide microarray technology, showcasing consolidated applications while highlighting some of the most intriguing novelties and emerging fields of use. The methodologies within this collection are of considerable value for both advanced users and new-comers in the peptide microarray arena, as the renowned contributors describe full coverage of the aspects related to their workflows, from microchip manufacturing to advanced analytical applications. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Peptide Microarrays: Methods and Protocols, Third Edition aims to make the use of peptide microarrays more and more accessible while stimulating further developments to sustain exciting discoveries in the biochemistry and medicine realms.
Author: Jordan Vail Price
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Since the advent of microarray technology in the early 1990's, the development of highly multiplex genomics tools has greatly outpaced the field of proteomics in terms of the generation of useful platforms for basic research and clinical analysis. Yet, to deliver on the great promise of genomics tools that analyze nucleic acids, technologies that permit the analysis of protein-protein interactions on a comparable scale need to be developed. Our group and others have shown that whole-protein and peptide microarrays can provide large amounts of information about the protein interactions that underlie the human immune response in health and disease. Here we describe three novel proteomics microarray platforms and demonstrate that the arrays can be used to gain insight into the antibody-mediated immune response in a spectrum of human diseases. In the first study, we detail the generation of a protein microarray that allows the detection of antibodies that bind to the molecular communication factors of the immune system: cytokines, chemokines, growth factors, and other circulating proteins. Using these arrays, we identified novel targets of autoantibodies in systemic lupus erythematosus, which may delineate a unique subgroup of patients within the spectrum of lupus. In the second study, we describe influenza antigen microarrays that permitted the identification of antibody reactivity to specific influenza hemagglutinin epitopes associated with poor or effective response to the seasonal influenza vaccine. These arrays have potential for development into a clinical diagnostic tool capable of predicting an individual's ability to mount an effective antibody response to vaccination. Finally, we report the development of a silicon-based peptide microarray developed in collaboration with researchers at the Intel Corporation. These "Intel arrays" hold great potential for ultimately enabling highly parallel, real-time measurement of protein-protein interaction with myriad possible downstream applications. The technologies we have developed move the field of multiplex proteomic analysis forward on many fronts, and constitute valuable additions to the proteomics toolkit available to researchers and clinicians. Moreover, our work demonstrates that detailed analysis of protein-protein interaction is required to make more informed models of different states of human health and disease.
Author: Dev Kambhampati
Publisher: John Wiley & Sons
ISBN: 3527605215
Category : Science
Languages : en
Pages : 276
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Book Description
This book is the first of its kind in the field of protein microarrays and addresses novel strategies for constructing highly functional and biocompatible microarrays for screening proteins. The list of authors consisting of world leading experts provide a roadmap for solving the complex challenges that are currently faced while monitoring protein-protein interactions over a wide range of microarray platforms. In doing so, they also offer a comprehensive overview of microarray surface chemistry, detection technologies, fabrication options for array development, and data analysis of numerous types of protein interactions. Topics covered include: -Types of biomolecular interactions -Surface chemistry -Detection technologies -Spotting technologies -Bioinformatics/data analysis. While primarily intended to serve as a reference for researchers and students embarking on the exciting fields of proteomics, drug discovery and clinical diagnostics, this technology is also expected to potentially impact the areas of food diagnostics, environmental monitoring and national security.
Author: Bertrand Jordan
Publisher: Springer Science & Business Media
ISBN: 3642282032
Category : Medical
Languages : en
Pages : 241
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Book Description
Microarray technology has made strong progress over the past decade, and there have also been significant changes in application areas, from nucleic acids to proteomics and from research to clinical applications. This book provides a comprehensive overview of microarrays in diagnostics and biomarker development, covering DNA, peptide, protein and tissue arrays. The focus is on entities that are in actual clinical use, or quite close, and on recent developments, such as peptide and aptamer arrays. A further topic is the miniaturisation towards “nanoarrays”, which is expected to have great potential in clinical applications. Relevant issues of bioinformatics and statistical analysis of array data are discussed in detail, as well as the barriers to the commercialisation of array-based tests and the vexing IP issues involved. Thus, the book should be very useful tor active array users as well as to newcomers seeking to make the best choice between different technologies.
Author: Ian Day
Publisher: Taylor & Francis
ISBN: 1000951707
Category : Medical
Languages : en
Pages : 194
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Book Description
The 'Advanced Methods' series is intended for advanced undergraduates, postgraduates and established research scientists. Titles in the series are designed to cover current important areas of research in life sciences, and include both theoretical background and detailed protocols. The aim is to give researchers sufficient theory, supported by references, to take the given protocols and adapt them to their particular experimental systems. Microarrays and Microplates title looks at the new microarray and microplate-based technologies which facilitate large-scale analysis of DNA sequence variants, mRNA molecules and proteins. The book provides a review of the various methodologies being used to identify genetic variants and gene regulation and guides readers through both the application of these methodologies and experimental procedures.
Author: Paul F. Predki
Publisher: CRC Press
ISBN: 1420009842
Category : Medical
Languages : en
Pages : 482
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Book Description
An ideal text for biotechnologists, protein chemists, and biochemists, Functional Protein Microarrays in Drug Discovery explores all aspects of functional protein microarrays, including basic principles, methods, and applications. The book discusses the generation of functional protein content and describes both standard and state-of-the-art fabrication methods. It reviews current and next generation approaches to assay detection and presents a wide range of applications, from biomolecular interaction discovery and characterization to immune response profiling. The book also addresses several fundamental computational issues, bioinformatics and data analysis.
Author: Robert S. Matson
Publisher: CRC Press
ISBN: 1439855641
Category : Medical
Languages : en
Pages : 313
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Book Description
Microarrays play an increasingly significant role in drug discovery. The commercial landscape has changed dramatically over the past few years and researchers have made great advancements with regard to construction and use. Now in its second edition, Applying Genomic and Proteomic Microarray Technology in Drug Discovery highlights, describes, and
Author: Hans-Joachim Müller
Publisher: Elsevier
ISBN: 008091666X
Category : Science
Languages : en
Pages : 229
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Book Description
Microarrays is an invaluable laboratory manual for anyone conducting experiments in the field of molecular biology or medical biochemistry who needs to understand and use microarray technologies. These technologies are especially appropriate in genome analysis, diagnostics, and studies involving differential gene expression. Providing straightforward explanations, the authors demonstrate proven methods for biochip application and an overview of presently available instruments, biochips, and software. Chapters cover the different requirements for DNA and protein chips, as well as spotters and scanners. The book also covers high throughput screening, patent research, and the minimum requirements for setting up or expanding a microarray laboratory. - Covers microarray applications, technology, and execution - Written in an approachable yet informative tone - Includes more than 100 detailed figures and graphs - Examines the history of microarrays and their future potential - Defines key terms from related disciplines - Contains a full chapter on the importance of database research and patents - Describes how to develop or improve one's own microarray laboratory
