Protease Inhibitors

Protease Inhibitors PDF Author: Neha Khandelwal
Publisher:
ISBN: 9783656378983
Category :
Languages : en
Pages : 48

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Book Description
Scientific Study from the year 2011 in the subject Biology - Human Biology, grade: -, - (National Chemical Laboratory, Pune), course: Post Graduate Doctoral Studies, language: English, abstract: This book chapter covers the previous and current research on plant protease inhibitors being conducted worldwide since its identification. Plant protease inhibitors exists as natural defense mechanism in plants. Solanaceous plants have highly been explored for the protease inhibitor expression and function against various insects of the order lepidoptera, coleoptera, diptera and many more. Plant protease inhibitors are the well studied class of plant defensive proteins. High level of up-regulation upon insect damage, significantly elevated levels in reproductive and storage organs as well as specificity to pest proteases ascertain their defensive function. In the present chapter, we introduced molecular basis of plant-insect interactions and focused on different classes of protease inhibitors based on their target protease(s).

Protease Inhibitors

Protease Inhibitors PDF Author: Neha Khandelwal
Publisher:
ISBN: 9783656378983
Category :
Languages : en
Pages : 48

Get Book Here

Book Description
Scientific Study from the year 2011 in the subject Biology - Human Biology, grade: -, - (National Chemical Laboratory, Pune), course: Post Graduate Doctoral Studies, language: English, abstract: This book chapter covers the previous and current research on plant protease inhibitors being conducted worldwide since its identification. Plant protease inhibitors exists as natural defense mechanism in plants. Solanaceous plants have highly been explored for the protease inhibitor expression and function against various insects of the order lepidoptera, coleoptera, diptera and many more. Plant protease inhibitors are the well studied class of plant defensive proteins. High level of up-regulation upon insect damage, significantly elevated levels in reproductive and storage organs as well as specificity to pest proteases ascertain their defensive function. In the present chapter, we introduced molecular basis of plant-insect interactions and focused on different classes of protease inhibitors based on their target protease(s).

Protease Inhibitors: Potential and Constraints

Protease Inhibitors: Potential and Constraints PDF Author: Neha Khandelwal
Publisher: GRIN Verlag
ISBN: 3656378479
Category : Science
Languages : en
Pages : 49

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Book Description
Scientific Study from the year 2011 in the subject Biology - Human Biology, , course: Post Graduate Doctoral Studies, language: English, abstract: This book chapter covers the previous and current research on plant protease inhibitors being conducted worldwide since its identification. Plant protease inhibitors exists as natural defense mechanism in plants. Solanaceous plants have highly been explored for the protease inhibitor expression and function against various insects of the order lepidoptera, coleoptera, diptera and many more. Plant protease inhibitors are the well studied class of plant defensive proteins. High level of up-regulation upon insect damage, significantly elevated levels in reproductive and storage organs as well as specificity to pest proteases ascertain their defensive function. In the present chapter, we introduced molecular basis of plant-insect interactions and focused on different classes of protease inhibitors based on their target protease(s).

Biopesticides in Environment and Food Security: Issues and Strategies

Biopesticides in Environment and Food Security: Issues and Strategies PDF Author: Opender Koul
Publisher: Scientific Publishers
ISBN: 9386347458
Category : Technology & Engineering
Languages : en
Pages : 474

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Book Description
Drivers behind food security and crop protection issues vis-à-vis the food losses caused by pests include rapid human population increase, climate change, loss of beneficial on-farm biodiversity, reduction in per capita cropped land, water shortages, and pesticide withdrawals. Integrated pest management, therefore, becomes a compulsory strategy in agriculture, which offers a 'toolbox' of complementary crop- and region-specific crop protection solutions to address these rising pressures. IPM aims at more sustainable solutions by using complementary technologies and one of them is the use of biopesticides including genetically modified cropping systems. The aim is to reduce pests below economic thresholds utilizing key 'ecological services', particularly biocontrol systems via semiochemicals, biopesticides, precision pest monitoring tools, and rapid diagnostics. In fact, we are facing twin problems of environment and food security for the expanding population and it is necessary to ensure adequate pesticide-free food. The ecofriendly nature of biopesticide products suggests environment protection and safety for natural enemies and non-target organisms. However, their adoption and use have lagged behind due to certain constraints like variable performance under field situations, lack of quality standards and interest by big industrial houses, and cumbersome regulatory procedures. The present book is an attempt to critically debate over all these issues and suggest a road map for future.

Design of Caspase Inhibitors as Potential Clinical Agents

Design of Caspase Inhibitors as Potential Clinical Agents PDF Author: Tom O'Brien
Publisher: CRC Press
ISBN: 9781420045413
Category : Science
Languages : en
Pages : 312

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Book Description
Presents the Therapeutic Potential for Caspase Inhibitors: Present and Future Caspases represent one of the most specific protease families described to date. These extremely important enzymes are crucial to the destruction of aberrant cells – the body’s self-protection mechanism for warding off the growth of abnormal cells, many of which can promote cancer. Design of Caspase Inhibitors as Potential Clinical Agents introduces cutting-edge evidence regarding caspases’ role in pro-inflammatory responses. New research now shows that the inhibition of caspase function is a critical component for the treatment of many diseases, including: Arthritic and neurological disorders Lung disease Hereditary fever syndromes Inflammatory bowel and skin diseases Sepsis Liver fibrosis Outlines Efforts to Develop Molecule Inhibitors for Caspase Activity Transformation Under the editorial guidance of authoritative inflammatory disease, small molecule discovery, and apoptosis researchers, the book organizes the wide array of caspase literature into one convenient resource. It also summarizes the relative difficulty of transitioning a caspase small molecule inhibitor from the lab to the clinic and suggests approaches to circumvent this difficulty. Taking a novel, yet core approach to disease treatment, this seminal work sets the stage to combat a slew of debilitating diseases through groundbreaking drug development.

Communities in Action

Communities in Action PDF Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309452961
Category : Medical
Languages : en
Pages : 583

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Book Description
In the United States, some populations suffer from far greater disparities in health than others. Those disparities are caused not only by fundamental differences in health status across segments of the population, but also because of inequities in factors that impact health status, so-called determinants of health. Only part of an individual's health status depends on his or her behavior and choice; community-wide problems like poverty, unemployment, poor education, inadequate housing, poor public transportation, interpersonal violence, and decaying neighborhoods also contribute to health inequities, as well as the historic and ongoing interplay of structures, policies, and norms that shape lives. When these factors are not optimal in a community, it does not mean they are intractable: such inequities can be mitigated by social policies that can shape health in powerful ways. Communities in Action: Pathways to Health Equity seeks to delineate the causes of and the solutions to health inequities in the United States. This report focuses on what communities can do to promote health equity, what actions are needed by the many and varied stakeholders that are part of communities or support them, as well as the root causes and structural barriers that need to be overcome.

Rational and Randomized Approaches to the Design of Macrocyclic Protease Inhibitors

Rational and Randomized Approaches to the Design of Macrocyclic Protease Inhibitors PDF Author: Naeem Yusuff
Publisher:
ISBN:
Category :
Languages : en
Pages : 438

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Book Description


Calpains

Calpains PDF Author: K K W Wang
Publisher: CRC Press
ISBN: 9781560327134
Category : Medical
Languages : en
Pages : 472

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Book Description
This new edition offers a clear and through examination of the most recent results of thirty years of research on calcium-activated-neutral protease (CANP or Calpain). Coverage includes the implications of the recently gained ability to produce functionally active recombinant calpain in various human disorders such as cerebal ischemia, traumatic brain and spinal cord injury, cataract formation, myocardial infarction, and Alzheimer's disease. The resulting research to find more selective calpain inhibitors is also discussed. With a copy of Calpain: Pharmacology and Toxicology of Calcium Dependent Protease you will better understand why the calpain research area is such an exciting and promising one.

Free Energy Calculations in Rational Drug Design

Free Energy Calculations in Rational Drug Design PDF Author: M. Rami Reddy
Publisher: Springer Science & Business Media
ISBN: 9780306466762
Category : Medical
Languages : en
Pages : 420

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Book Description
Free energy calculations represent the most accurate computational method available for predicting enzyme inhibitor binding affinities. Advances in computer power in the 1990s enabled the practical application of these calculations in rationale drug design. This book represents the first comprehensive review of this growing area of research and covers the basic theory underlying the method, numerous state of the art strategies designed to improve throughput and dozen examples wherein free energy calculations were used to design and evaluate potential drug candidates.

Proteinase and Peptidase Inhibition

Proteinase and Peptidase Inhibition PDF Author: H. John Smith
Publisher: CRC Press
ISBN: 0203219171
Category : Medical
Languages : en
Pages : 440

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Book Description
Cellular proteinases and their physiological role in normal and disease states have been the subject of great interest over recent decades. At present, specific protease inhibitors are exploited both as tools in unraveling the role of individual proteinases in particular cellular processes and for the development of chemotherapeutic agents for the

New and Future Development in Biopesticide Research: Biotechnological Exploration

New and Future Development in Biopesticide Research: Biotechnological Exploration PDF Author: Surajit De Mandal
Publisher: Springer Nature
ISBN: 9811639892
Category : Science
Languages : en
Pages : 305

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Book Description
This book discusses different approaches for successful pest-management through biotechnological interventions. Pest management is directly associated with the agricultural productivity. The book introduces the reader to various kinds of biopesticides that have been developed and are being developed for field application. Chemical pesticides have been widely used to control pests, and these induce pesticide resistance as well as other environmental problems. This book discusses the necessity to develop alternate pest control strategies, especially environment-friendly and target-specific biopesticides against destructive pests. The book describes important aspects such as microbial biopesticides, plant-based biopesticides, natural products that act against pests and the various other biotechnological advances and limitations of these biopesticides. It provides an in-depth knowledge of the latest research and development in the area of biopesticides. This informative book is meant for students and researchers in the fields of biotechnology, agriculture and applied microbiology.