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Author: John M Evans
Publisher: CRC Press
ISBN: 0203304411
Category : Science
Languages : en
Pages : 521
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Book Description
Potassium ions K+ ions are vital in physiological processes, particularly with regard to the cardiovascular system. Modulators influence the channels through which these ions flow and the research into modulator drugs of these channels is the subject of rapidly-advancing research. This work is intended to be of use as a tool for those working in the pharmaceutical industry. Early chapters concentrate on the synthesis and structure-activity relationships of potassium channel modulators. These are followed by discussion on the application of these drugs to different target organs, such as the cardiovascular system and the airways. The book concludes with a broad overview of clinical experience and future prospects.; The authors show how potassium channel activators and potassium channel blockers each have a role to play as therapeutic agents for many disorders, including asthma and respiratory tract disorders, diseases of the central nervous system such as epilepsy, and vascular diseases such as angina, peripheral vascular disease and high blood pressure. This book should therefore also be of interest to those researching into this wide range of diseases.
Author: John M Evans
Publisher: CRC Press
ISBN: 0203304411
Category : Science
Languages : en
Pages : 521
Get Book Here
Book Description
Potassium ions K+ ions are vital in physiological processes, particularly with regard to the cardiovascular system. Modulators influence the channels through which these ions flow and the research into modulator drugs of these channels is the subject of rapidly-advancing research. This work is intended to be of use as a tool for those working in the pharmaceutical industry. Early chapters concentrate on the synthesis and structure-activity relationships of potassium channel modulators. These are followed by discussion on the application of these drugs to different target organs, such as the cardiovascular system and the airways. The book concludes with a broad overview of clinical experience and future prospects.; The authors show how potassium channel activators and potassium channel blockers each have a role to play as therapeutic agents for many disorders, including asthma and respiratory tract disorders, diseases of the central nervous system such as epilepsy, and vascular diseases such as angina, peripheral vascular disease and high blood pressure. This book should therefore also be of interest to those researching into this wide range of diseases.
Author: AH Weston
Publisher: Wiley-Blackwell
ISBN: 9780632030446
Category : Medical
Languages : en
Pages : 528
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Book Description
Modulation of potassium channels plays a very important part in nerve cell function in the autonomic nervous system. Compounds are now in development which can open or close potassium channels and will have numerous therapeutic applications. The major areas of clinical relevance will be hypertension, asthma and irritable bladder syndrome. The book describes the pharmacology of the channels and strategies for the design of drugs which exploit them. It consists of 17 chapters by international experts in the field which are written at a high level and will be of interest to pharmacologists and those in related clinical research disciplines
Author: Jeffrey Noebels
Publisher: OUP USA
ISBN: 0199746540
Category : Medical
Languages : en
Pages : 1258
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Book Description
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Author: Noel John Chambers
Publisher:
ISBN:
Category : Potassium channels
Languages : en
Pages : 350
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Book Description
Author: National Institute of Neurological and Communicative Disorders and Stroke. Epilepsy Branch
Publisher:
ISBN:
Category : Anticonvulsants
Languages : en
Pages : 26
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Book Description
Author: Nikita Gamper
Publisher: Springer Nature
ISBN: 3030840522
Category : Medical
Languages : en
Pages : 546
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Book Description
The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology.
Author: Chi-Kong Yeung
Publisher:
ISBN:
Category :
Languages : en
Pages : 289
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Book Description
The aim of this work was to investigate the actions of potassium channel modulating agents on the motility of the gastrointestinal tract of mice in vitro and in vivo. .....
Author: Simone Furini
Publisher: Springer Nature
ISBN: 1071638181
Category :
Languages : en
Pages : 298
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Book Description
Author: David J. Triggle
Publisher: John Wiley & Sons
ISBN: 3527607749
Category : Science
Languages : en
Pages : 492
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Book Description
Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.
Author:
Publisher: Academic Press
ISBN: 0128052104
Category : Science
Languages : en
Pages : 404
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Book Description
Ion Channels as Therapeutic Targets is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Discusses the use of ion channels as therapeutic targets Chapters are written by authorities in their field Targeted to a wide audience of researchers, specialists, and students
