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Author: Anilkumar Parambath
Publisher: Elsevier
ISBN: 0443137757
Category : Medical
Languages : en
Pages : 0
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Book Description
Oral delivery?is the most preferred route of the delivery of therapeutics for treating a number of diseases. The challenge of oral drug administration is to assure a predictive and reproducible pharmacokinetic profile of the active pharmaceutical ingredient (API). Polymers play an important role to achieve the targeted release profile consistently of an API in vivo by various functionalities like drug protection from gastric juice, fast release and supersaturation or release within a targeted area of the GI tract. This book is divided into two parts, covering the fundamentals of oral drug delivery and the various aspects of polymer technology in oral drug delivery, from classification and synthesis, to applications and regulatory factors. Provides a comprehensive update on the state of polymer technology for oral drug delivery, bringing the reader up-to-speed via a single reference. Covers a range of polymer technology types, including capsule forming polymers, matrix formers, functional polymer coatings and more. Contributions from global experts spanning both academia and industry, offering an interdisciplinary and translational approach to polymers for oral drug delivery.
Author: Anilkumar Parambath
Publisher: Elsevier
ISBN: 0443137757
Category : Medical
Languages : en
Pages : 0
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Book Description
Oral delivery?is the most preferred route of the delivery of therapeutics for treating a number of diseases. The challenge of oral drug administration is to assure a predictive and reproducible pharmacokinetic profile of the active pharmaceutical ingredient (API). Polymers play an important role to achieve the targeted release profile consistently of an API in vivo by various functionalities like drug protection from gastric juice, fast release and supersaturation or release within a targeted area of the GI tract. This book is divided into two parts, covering the fundamentals of oral drug delivery and the various aspects of polymer technology in oral drug delivery, from classification and synthesis, to applications and regulatory factors. Provides a comprehensive update on the state of polymer technology for oral drug delivery, bringing the reader up-to-speed via a single reference. Covers a range of polymer technology types, including capsule forming polymers, matrix formers, functional polymer coatings and more. Contributions from global experts spanning both academia and industry, offering an interdisciplinary and translational approach to polymers for oral drug delivery.
Author: Fang Liu
Publisher: Smithers Rapra
ISBN: 1847355382
Category : Medical
Languages : en
Pages : 172
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Book Description
The preferred route for drug delivery remains the oral route, but oral drug delivery has now developed beyond traditional dosage forms such as tablets and capsules. Nowadays it is possible to use polymers to allow drugs to be targeted to specific sites in the gastrointestinal tract, and to extend the drug release profile. In addition, polymers can be engineered to allow oral delivery of such complex molecules as proteins, peptides, and even genes. This book gives a comprehensive summary of oral drug delivery systems, both conventional and novel, and the ways in which polymers have been adapted for these systems. Particular attention is devoted to gastrointestinal physiology and the physio-chemical properties of polymers in order to understand the factors affecting their performance in practice. This update will interest everyone involved in the pharmaceutical world, whether in academia or in industry. It will be of particular value to those responsible for designing new oral drug delivery systems involving polymers. It will provide a useful reference text both for researchers and manufacturers, and will also be a helpful introduction for students of all levels to the application of polymers in pharmacy.
Author: Glen S. Kwon
Publisher: CRC Press
ISBN: 9780824725327
Category : Medical
Languages : en
Pages : 680
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Book Description
Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.
Author: Rebecca A. Bader
Publisher: John Wiley & Sons
ISBN: 1118747801
Category : Social Science
Languages : en
Pages : 395
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Book Description
Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.
Author: Clive G. Wilson
Publisher: Springer Science & Business Media
ISBN: 1461410045
Category : Medical
Languages : en
Pages : 415
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Book Description
Controlled Release in Oral Drug Delivery provides focus on specific topics, complementing other books in the initial CRS series. Each chapter sets the context for the inventions described and describe the latitude that the inventions allow. In order to provide some similar look to each chapter, the coverage includes the historical overview, candidate drugs, factors influencing design and development, formulation and manufacturing and delivery system design. This volume was written along three main sections: the relevant anatomy and physiology, a discussion on candidates for oral drug delivery and the major three groups of controlled release systems: diffusion control (swelling and inert matrices); environmental control (pH sensitive coatings, time control, enzymatic control, pressure control) and finally lipidic systems.
Author: Peter J. Tarcha
Publisher: CRC Press
ISBN: 9780849356520
Category : Medical
Languages : en
Pages : 300
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Book Description
Polymers for Controlled Drug Delivery addresses the challenges of designing macromolecules that deliver therapeutic agents that function safely and in concert with living organisms. The book primarily discusses classes of polymers and polymeric vehicles, including particulates, such as latexes, coacervates, ion-exchange resins, and liposomes, as well as non-particulate vehicles such as enteric coatings, mediators, and bioadhesives. Other topics discussed include diffusion; biodegradation-controlled delivery; animal model studies for toxicity, metabolism, and elimination testing; and FDA requirements for clinical studies. Drug delivery researchers will find this book to be an invaluable reference tool.
Author: Ambikanandan Misra
Publisher: Elsevier
ISBN: 0128226684
Category : Technology & Engineering
Languages : en
Pages : 594
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Book Description
Applications of Polymers in Drug Delivery, Second Edition, provides a comprehensive resource for anyone looking to understand how polymeric materials can be applied to current, new, and emerging drug delivery applications. Polymers play a crucial role in modulating drug delivery and have been fundamental in the successful development of many novel drug delivery systems. This book describes the development of polymeric systems, ranging from conventional dosage forms to the most recent smart systems. Regulatory and intellectual property aspects as well as the clinical applicability of polymeric drug delivery systems are also discussed. The chapters are organized by specific delivery route, offering methodical and detailed coverage throughout. This second edition has been thoroughly revised to include the latest developments in the field. This is an essential book for researchers, scientists, and advanced students, in polymer science, drug delivery, pharmacology/pharmaceuticals, materials science, tissue engineering, nanomedicine, chemistry, and biology. In industry, this book supports scientists, R&D, and other professionals, working on polymers for drug delivery applications. Explains how polymers can be prepared and utilized for all major drug delivery routes Presents the latest advances, including drug targeting, polymeric micelles and polymersomes, and the delivery of biologicals and nucleic acid therapeutics Includes appendices with in-depth information on pharmaceutical properties of polymers and regulatory aspects
Author: Vijay Kumar Thakur
Publisher: John Wiley & Sons
ISBN: 1119041449
Category : Technology & Engineering
Languages : en
Pages : 610
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Book Description
Polymers are one of the most fascinating materials of the present era finding their applications in almost every aspects of life. Polymers are either directly available in nature or are chemically synthesized and used depending upon the targeted applications.Advances in polymer science and the introduction of new polymers have resulted in the significant development of polymers with unique properties. Different kinds of polymers have been and will be one of the key in several applications in many of the advanced pharmaceutical research being carried out over the globe. This 4-partset of books contains precisely referenced chapters, emphasizing different kinds of polymers with basic fundamentals and practicality for application in diverse pharmaceutical technologies. The volumes aim at explaining basics of polymers based materials from different resources and their chemistry along with practical applications which present a future direction in the pharmaceutical industry. Each volume offer deep insight into the subject being treated. Volume 1: Structure and Chemistry Volume 2: Processing and Applications Volume 3: Biodegradable Polymers Volume 4: Bioactive and Compatible Synthetic/Hybrid Polymers
Author: David Jones
Publisher: iSmithers Rapra Publishing
ISBN: 9781859574799
Category : Medical
Languages : en
Pages : 138
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Book Description
Annotation The review focuses on the use of pharmaceutical polymer for controlled drug delivery applications. Examples of pharmaceutical polymers and the principles of controlled drug delivery are outlined and applications of polymers for controlled drug delivery are described. The field of controlled drug delivery is vast therefore this review aims to provide an overview of the applications of pharmaceutical polymers. The review is accompanied by approximately 250 abstracts taken from papers and books in the Rapra Polymer Library database, to facilitate further reading on this subject.
Author: Hong Wen
Publisher: John Wiley & Sons
ISBN: 1118060326
Category : Science
Languages : en
Pages : 571
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Book Description
This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.
