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Author: Melanie McCabe White
Publisher: Elsevier
ISBN: 0080539122
Category : Science
Languages : en
Pages : 131
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Book Description
Platelets are fragments of blood cells that occur in the blood of vertebrates and are associated with blood clotting. Scientists have made great strides in recent years in understanding what stimulates platelets to form blood clots at the molecular level and in developing drugs to inhibit platelet action. Their work has a direct effect on millions of people who deal with cardiovascular disease, strokes, surgery, physical trauma, and other conditions. While references to platelet function have been included in some large texts, there has not been a basic reference manual that researchers and clinicians can use in their daily work until now.Platelet Protocols fills the need for a straightforward and comprehensive laboratory manual on current procedures for evaluating and analyzing platelet function and abnormalities. It is an easy-to-read, understandable resource which can be kept at the bench and referred to frequently by scientists, clinicians, and laboratory staff involved in platelet related areas. Topics range from the basics of anticoagulants to the latest developments in platelet testing.Includes: - A basic introduction to platelet anatomy and physiology - Testing procedures for new anti-platelet therapies - Descriptions of platelet function abnormalities - Therapeutic approaches to inhibition of platelet function - Step-by-step methodologies with clear explanations - Helpful appendixes of recipes, instructions, sources of reagents, and more
Author: Melanie McCabe White
Publisher: Elsevier
ISBN: 0080539122
Category : Science
Languages : en
Pages : 131
Get Book Here
Book Description
Platelets are fragments of blood cells that occur in the blood of vertebrates and are associated with blood clotting. Scientists have made great strides in recent years in understanding what stimulates platelets to form blood clots at the molecular level and in developing drugs to inhibit platelet action. Their work has a direct effect on millions of people who deal with cardiovascular disease, strokes, surgery, physical trauma, and other conditions. While references to platelet function have been included in some large texts, there has not been a basic reference manual that researchers and clinicians can use in their daily work until now.Platelet Protocols fills the need for a straightforward and comprehensive laboratory manual on current procedures for evaluating and analyzing platelet function and abnormalities. It is an easy-to-read, understandable resource which can be kept at the bench and referred to frequently by scientists, clinicians, and laboratory staff involved in platelet related areas. Topics range from the basics of anticoagulants to the latest developments in platelet testing.Includes: - A basic introduction to platelet anatomy and physiology - Testing procedures for new anti-platelet therapies - Descriptions of platelet function abnormalities - Therapeutic approaches to inhibition of platelet function - Step-by-step methodologies with clear explanations - Helpful appendixes of recipes, instructions, sources of reagents, and more
Author: Jonathan M. Gibbins
Publisher: Springer Science & Business Media
ISBN: 1592597823
Category : Medical
Languages : en
Pages : 389
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Book Description
12 The average human body has in the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are, however, far from understanding precisely how platelets become activated under physiological and pathophysiological conditions. In addition, there are large gaps in our knowledge of platelet production from their giant precursor cell, the megakar- cyte. Understanding megakaryocyte biology will be crucial for the development of platelet gene targeting. The aim of Platelets and Megakaryocytes is therefore to bring together established and recently developed techniques to provide a comprehensive guide to the study of both the platelet and the megakaryocyte. It consists of five s- tions split between two volumes. The more functional assays appear in Volume 1, whereas Volume 2 includes signaling techniques, postgenomic methods, and a n- ber of key perspectives chapters. Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of microparticles. Although one would ideally wish to perform experiments with human platelets, studies within the circulation using intravital microscopy require the use of animal models, which are described in Chapter 16, vol. 1.
Author: Gregory A. Denomme
Publisher: Elsevier
ISBN: 0080536905
Category : Medical
Languages : en
Pages : 197
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Book Description
This essential methods manual for immunohematologists (or hematologists and immunohematologists) provides information on genes that encode antigens on red blood cells, platelets and neutrophils. The book begins by covering general concepts in molecular biology and specific protocols such as DNA preparation, PCR-RFLP and allele-specific PCR. Information on the erythrocyte, platelet and neutrophil antigen systems and the molecular basis of polymorphisms are presented clearly in a gene facts sheet format. Database accession numbers and useful adjuncts such as Request forms, worksheets for PCR/enzyme digests also serve to benefit the user. The information is clearly presented and easily accessible and is complemented by the excellent diagrams and tabular material. This book is invaluable for both new and experienced researchers in the field and other related disciplines. - Essential for hematologists and those involoved in tissue typing and the study of human genetic polymorphisms - Presents clearly and concisely the information on a particular variant and the technique used to detect it - Organized by antigen and provides sequences of polymorphisms and primers - Details the general concepts and critical information on genes, their products, and sources of relevant nucleic acids - Includes protocols that allow investigators to set up assays with minimal effort (protocols include primers, reagents, reaction conditions, sizes of amplified products, restriction fragment digests, and the relevant safety information) - Provides information that helps interpret results in clinical settings - Contains additional sources of information (e.g., key references, web site addresses, glossary, Database accession numbers, request forms, and worksheets for PCR/enzyme digests)
Author: Jonathan M. Gibbins
Publisher: Humana Press
ISBN: 9781493985845
Category : Science
Languages : en
Pages : 287
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Book Description
The main aim of this fourth volume is to complement the first three volumes published in 2004 and 2012 by adding advanced methodologies and perspectives. Chapters guide readers through new techniques into the study of platelets and megakaryocytes, including new imaging approaches, new methods for platelet production in vitro, and systems biology approaches. Written in the highly successful Methods in Molecular Biology series format, methods chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting or avoiding known pitfalls. Authoritative and up-to-date, Platelets and Megakaryocytes: Volume 4, Additional Protocols and Perspectives adds a wealth of new expertise for the labs of scientists working in this key biological area of study.
Author: Hunter B. Moore
Publisher: Springer Nature
ISBN: 3030536068
Category : Medical
Languages : en
Pages : 794
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Book Description
The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities. Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.
Author: Marc Quirynen
Publisher: Quintessenz Verlag
ISBN: 3868676333
Category : Medical
Languages : en
Pages : 437
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Book Description
This book will guide clinicians to achieve great results with L-PRF. It starts with basic science chapters on tissue regeneration, blood centrifugation, and an explanation of the biologic power of platelet concentrates. However, the true value of this book lies in an evidence-based evaluation of the benefits of L-PRF in periodontal and maxillofacial surgery, as well as in chronic wound therapy. For each treatment, a step-by-step approach has been created by experienced clinicians. The most crucial steps are explained in 18 videos via augmented reality.
Author: Neil S. Sadick
Publisher: Springer Nature
ISBN: 3030662306
Category : Medical
Languages : en
Pages : 120
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Book Description
This book details the uses of platelet-rich plasma (PRP) techniques for dermatologic purposes and describes the techniques and protocols for its application in clinical practice. Concise and practical, this reference covers not only the procedural steps in collecting PRP from a patient, but also applications in wound healing, hair loss, skin rejuvenation, scarring, and face and body augmentation. It addresses the issues that are caused by fad procedures, such as the "Vampire Facelift," and emphasizes the importance of reliable information in these cases. Chapters are supplemented with multimedia including high-quality images, illustrations, and an instructional video. Platelet-Rich Plasma in Dermatologic Practice is written for clinicians in practice looking to offer alternatives to more invasive aesthetic surgery techniques.
Author: Cees Smit Sibinga
Publisher: Springer Science & Business Media
ISBN: 9780792313120
Category : Medical
Languages : en
Pages : 312
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Book Description
The first International Meeting on Apheresis was held in Dyon in 1984. At the congress it became clear that both the technical and therapeutic sides developed very rapidly and it appeared fruitful to bring together the investigators of the different countries working in the areas. At that time immunology had come to pervade many clinical specialities, and hemapheresis, especially plasmapheresis was considered a therapeutic tool in many immunological diseases which hitherto had proved to be fatal. New methods to identify certain antibodies and circulating immune complexes in the serum and the possibilities to remove them from the blood by several techniques (filtration, centrifugation, immunoabsorp tion) led to an almost uncontrolled use of plasma exchange in a variety of diseases. Since then the technical possibilities of this technique were further recognized, as was the impact of immunology on many diseases, and the possibilities to collect specific components for therapeutic pur poses. But also we became aware of the limited contributions of anec dotal data on successes or failures of apheresis as adjuvant treatment. Therefore international prospective studies were initiated to make critical assessment possible of apheresis in various diseases.
Author: Richard J. Miron
Publisher: John Wiley & Sons
ISBN: 1119406803
Category : Medical
Languages : en
Pages : 427
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Book Description
The first book devoted exclusively to the subject, Platelet Rich Fibrin in Regenerative Dentistry offers comprehensive, evidence-based coverage of the biological basis and clinical applications of PRF in dentistry. Co-edited by a leading researcher in tissue regeneration and the inventor of the PRF technique, it brings together original contributions from expert international researchers and clinicians. Chapters cover the biological foundation of PRF before addressing specific uses of the technology within clinical dentistry. Topics describe the use of PRF in many dental applications, including extraction socket management, sinus lifting procedures, root coverage, periodontal regeneration, soft tissue healing around implants, guided bone regeneration, and facial esthetics. The text is supplemented with color photographs and explanatory illustrations throughout. Platelet Rich Fibrin in Regenerative Dentistry: Biological Background and Clinical Indications is an indispensable professional resource for periodontists, oral surgeons and oral and maxillofacial surgeons, as well as general dentists who use PRF or are interested in introducing it into their practices. It is also an excellent reference for undergraduate and postgraduate dental students.
Author: Rhishikesh Thakre
Publisher: Jaypee Brothers Medical Publishers
ISBN: 9389188482
Category : Medical
Languages : en
Pages : 519
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Book Description
Section 1: Clinical Approach to Sick Newborn 1Identification of "At Risk" Newborn & Admission to SCNU/NICU 2Hypothermia 3Respiratory Distress 4Shock 5Suspected infection 6Neonatal Seizures 7Indirect Jaundice 8Suspected congenital heart defect 9Fluids & Electrolyte therapy 10Hypoglcyemia 11Hypocalcemia 12Polycythemia 13Gastric residues/Feed intolerance 14Bleeding Newborn 15Thrombocytopenia 16Anemia 17Neonatal Encephalopathy 18Floppy Newborn 19Suspected inborn errors of metabolism 20Disorders of Sexual Differentiation 21Neonatal Transport 22Abdominal distension in the newborn (Medical vs. Surgical) 23Apnea 24Blistering skin disorder 25Systemic fungal infection Section 2: Care of Well Newborn 26Evaluation in delivery room 27First evaluation in OPD 28Growth monitoring 29Newborn metabolic screening 30Vitamin K 31Not passed urine in 48 hours 32Not passed stool in 48 hours 33Direct jaundice 34Congenital hydronephrosis 35Common Problems in the newborn OPD 36Optimizing Breastfeeding in Normal Newborn 37Golden Hour Care for Preterms 38Colic Section 3: Care of preterm/Low birth weight/High risk newborn 39Kangaroo Care 40Feeding LBW 41Nutritional supplementation 42Discharge planning 43ROP Screening 44Hearing Screening 45Follow up of high risk newborn 46IVH and PVL Screening and Classification 47Developmental supportive care 48Antental Corticosteroids 49Breast milk storage and handling 50Immunisation in LBW Section 4: Neonatal Dilemma's 51Cryptorchidism 52Baby born to HIV positive mother 53Baby born to HbsAg positive mother 54Baby born to mother with tuberculosis 55Baby born to mother with chicken pox 56Baby born to VDRL positive mother 57Breast feeding & Medications 58Stem cell Banking: Scope and Practice 59Declaring newborn death Section 5: Specific Therapies 60Antibiotic policy 61Surfactant replacement therapy 62CPAP 63INSURE 64Blood component therapy 65Total parenteral nutrition 66Oxygen therapy 67Chest physiotherapy Section 6: Interpreting Tests 68Sepsis Screen 69CRP 70Blood culture 71Thyroid function tests 72Xray Chest 73Congenital renal disorders Section 7: Miscellaneous Topics 74Parent Counselling 75Disinfection and sterilizatioin 76Handwashing 77Pain management 78Coping with death 79Birth Injury 80Best Practices in NICU 81Checklists (Pre-surgery, Exchange Transfusion, Golden hour of preterm, Pre-discharge Normal newborn, Pre-discharge VLBW infant, VAP bundle, CLABSI Bundle, Formula feed preparation) 82Use of NICU Charts, Algorithms, Calculators: Mobile apps and Website links
