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Author: Jinghua Hu
Publisher: CRC Press
ISBN: 0429888945
Category : Medical
Languages : en
Pages : 360
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Book Description
This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of tubular epithelial cells. Thus, ADPKD belongs to ciliopathies, a group of disorders caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies. Key Features Explores the role of cilia in polycystic kidney disease Focuses on myriad state-of-the-art methods and techniques Reviews specific mutations integral to this autosomal genetic disease Includes discussions of model systems
Author: Jinghua Hu
Publisher: CRC Press
ISBN: 0429888945
Category : Medical
Languages : en
Pages : 360
Get Book Here
Book Description
This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of tubular epithelial cells. Thus, ADPKD belongs to ciliopathies, a group of disorders caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies. Key Features Explores the role of cilia in polycystic kidney disease Focuses on myriad state-of-the-art methods and techniques Reviews specific mutations integral to this autosomal genetic disease Includes discussions of model systems
Author: Jong Hoon Park
Publisher: Springer
ISBN: 9811020418
Category : Medical
Languages : en
Pages : 128
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Book Description
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Author: Jared James Grantham
Publisher: Rockhill Books
ISBN: 9781611691283
Category : Bethesda (Maryland).
Languages : en
Pages : 282
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Book Description
In this page-turner, Dr. Jared Grantham, a noted researcher with the University of Kansas Medical Center, takes the reader through his life of scientific discovery, but a life also of hardship beset by tragedy. It follows a career path that begins in Kansas, finishes in Kansas and ultimately leads to the development of a treatment for a devastating kidney disease suffered by his boyhood friend.
Author: Fred F. Ferri
Publisher: Elsevier Health Sciences
ISBN: 0323679773
Category : Medical
Languages : en
Pages : 7615
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Book Description
Significantly updated with the latest developments in diagnosis and treatment recommendations, Ferri's Clinical Advisor 2020 features the popular "5 books in 1" format to organize vast amounts of information in a clinically relevant, user-friendly manner. This efficient, intuitive format provides quick access to answers on 1,000 common medical conditions, including diseases and disorders, differential diagnoses, and laboratory tests – all reviewed by experts in key clinical fields. Updated algorithms, along with hundreds of new figures, tables, and boxes, ensure that you stay current with today's medical practice. - Contains significant updates throughout, covering all aspects of current diagnosis and treatment. - Features 27 all-new topics including chronic traumatic encephalopathy, medical marijuana, acute respiratory failure, gallbladder carcinoma, shift work disorder, radial tunnel syndrome, fertility preservation in women, fallopian tube cancer, primary chest wall cancer, large-bowel obstruction, inguinal hernia, and bundle branch block, among others. - Includes a new appendix covering Physician Quality Reporting System (PQRS) Measures. - Provides current ICD-10 insurance billing codes to help expedite insurance reimbursements. - Patient Teaching Guides for many of the diseases and disorders are included, most available in both English and Spanish versions, which can be downloaded and printed for patients.
Author: Philip K. Dick
Publisher: Houghton Mifflin Harcourt
ISBN: 0547549253
Category : Biography & Autobiography
Languages : en
Pages : 1003
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Book Description
"A great and calamitous sequence of arguments with the universe: poignant, terrifying, ludicrous, and brilliant. The Exegesis is the sort of book associated with legends and madmen, but Dick wasn't a legend and he wasn't mad. He lived among us, and was a genius."-Jonathan Lethem Based on thousands of pages of typed and handwritten notes, journal entries, letters, and story sketches, The Exegesis of Philip K. Dick is the magnificent and imaginative final work of an author who dedicated his life to questioning the nature of reality and perception, the malleability of space and time, and the relationship between the human and the divine. Edited and introduced by Pamela Jackson and Jonathan Lethem, this will be the definitive presentation of Dick's brilliant, and epic, final work. In The Exegesis, Dick documents his eight-year attempt to fathom what he called "2-3-74," a postmodern visionary experience of the entire universe "transformed into information." In entries that sometimes ran to hundreds of pages, Dick tried to write his way into the heart of a cosmic mystery that tested his powers of imagination and invention to the limit, adding to, revising, and discarding theory after theory, mixing in dreams and visionary experiences as they occurred, and pulling it all together in three late novels known as the VALIS trilogy. In this abridgment, Jackson and Lethem serve as guides, taking the reader through the Exegesis and establishing connections with moments in Dick's life and work.
Author: Philip K. Dick
Publisher: Houghton Mifflin Harcourt
ISBN: 0547572484
Category : Fiction
Languages : en
Pages : 291
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Book Description
Slavery is back. America, 1962. Having lost a war, America finds itself under Nazi Germany and Japan occupation. A few Jews still live under assumed names. The 'I Ching' is prevalent in San Francisco. Science fiction meets serious ideas in this take on a possible alternate history.
Author: Philip K. Dick
Publisher: Houghton Mifflin Harcourt
ISBN: 0547572298
Category : Fiction
Languages : en
Pages : 241
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Book Description
A mind-bending, classic Philip K. Dick novel about the perception of reality. Named as one of Time's 100 best books.
Author: Philip K. Dick
Publisher: Vintage
ISBN: 1400096073
Category : Fiction
Languages : en
Pages : 210
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Book Description
A master of science fiction, a voice of the changing counterculture, and a genuine visionary, Philip K. Dick wrote about reality, entropy, deception, and the plight of being alive in the modern world. Through his remarkable career Dick has established himself as a writer of the first order and his dreams of the future have proven to be eerily prophetic and even more prescient than when he wrote them. Vintage PKD features extracts from The Man in the High Castle, The Three Stigmata of Palmer Eldritch, Ubik, A Scanner Darkly, VALIS, and stories including “The Days of Perky Pat,” “A Little Something for Us Tempunauts," and “I Hope I Shall Arrive Soon,” along with essays and letters currently unavailable in book form. Vintage Readers are a perfect introduction to some of the great modern writers, presented in attractive, affordable paperback editions.
Author: K.D. Gardner
Publisher: Springer Science & Business Media
ISBN: 9400904576
Category : Medical
Languages : en
Pages : 441
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Book Description
This is a book about renal cysts and cystic kidneys. Its contributors have created a resource of current information in a field that once aroused only curiosity, but that now stands at the leading edge of molecular nephrology. Its authorship includes 'oldtimers', who bring the wisdom of experience, and 'newcomers', whose presence attests to the contributions made by the investigative and technological advances of the past decade. Its text is organized to carry the reader from renal cyst to cystic renal disease. Each of its chapters defines or explores a challenge or an advance. Cells that line renal cysts are diverse in structure, type, and perhaps function. The cysts themselves lie within an interstitium that is not normal and may influence cyst development and growth. Experimental analogs of human disease offer increasing opportunities to basic researchers to examine, in sequence and under controlled circumstances, those events that favor nephron dilation, cyst growth and ultimate renal failure.
Author: Xiaogang Li
Publisher:
ISBN: 9780994438102
Category :
Languages : en
Pages :
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Book Description
Polycystic kidney disease (PKD) is characterized by the presence of fluid-filled cysts in the kidneys. It is the fourth most common cause of chronic renal insufficiency or end-stage kidney disease. This book focuses on the basic and clinical aspects of the burgeoning PKD research under three sections. Section 1 provides a comprehensive guide to the diagnosis, management and treatment of PKD. Section 2 covers most of the fundamental molecular and cellular mechanisms underlying PKD, and how this knowledge is contributing to the development of potential novel therapeutic agents. Finally, section 3 focuses on extra-renal or secondary complications of PKD.
