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Author: Hanne Hjorth Tonnesen
Publisher: CRC Press
ISBN: 1420023594
Category : Medical
Languages : en
Pages : 450
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Book Description
Providing the guidance needed for formulation, handling, and quality control of photolabile drugs, Photostability of Drugs and Drug Formulations, Second Edition explores the significance of new information on drug photoreactivity in a pharmaceutical context. Completely revised and updated, with chapter authors drawn from an international panel of experts, the book supplies the background necessary for planning standardized photochemical stability studies as a part of drug development and formulation work. It contains comprehensive coverage of the physical and chemical aspects of drug photoreactivity, formulation, stability testing, and drug design/discovery in one resource. The contents have been reorganized to focus on the standardization of photostability testing of drug substances and products, in vitro photoreactivity screening of drugs, and various aspects of the formulation of photoreactive substances. The information on in vitro screening of drug photoreactivity is of great relevance for scientists who are developing and validating a set of testing protocols to address photosafety. Discussing kinetic and chemical aspects of drug photodecomposition as well as the practical problems frequently encountered in photochemical stability testing, this book helps you design a test protocol and interpret the results. Features Assists non-experts in this field design a test protocol and interpret the results Covers in vitro and in vivo aspects of interactions between drugs and light Explores the kinetic and chemical aspects of drug photodecomposition Discusses the problems frequently encountered in photochemical stability testing Provides guidance on how to address photosafety assessments and labeling requirements of potentially photoreactive drugs Highlights the practical implications of drug photodecomposition from a pharmaceutical viewpoint Offers specific guidance in photostability testing and screening of drug photoreactivity
Author: Hanne Hjorth Tonnesen
Publisher: CRC Press
ISBN: 1420023594
Category : Medical
Languages : en
Pages : 450
Get Book Here
Book Description
Providing the guidance needed for formulation, handling, and quality control of photolabile drugs, Photostability of Drugs and Drug Formulations, Second Edition explores the significance of new information on drug photoreactivity in a pharmaceutical context. Completely revised and updated, with chapter authors drawn from an international panel of experts, the book supplies the background necessary for planning standardized photochemical stability studies as a part of drug development and formulation work. It contains comprehensive coverage of the physical and chemical aspects of drug photoreactivity, formulation, stability testing, and drug design/discovery in one resource. The contents have been reorganized to focus on the standardization of photostability testing of drug substances and products, in vitro photoreactivity screening of drugs, and various aspects of the formulation of photoreactive substances. The information on in vitro screening of drug photoreactivity is of great relevance for scientists who are developing and validating a set of testing protocols to address photosafety. Discussing kinetic and chemical aspects of drug photodecomposition as well as the practical problems frequently encountered in photochemical stability testing, this book helps you design a test protocol and interpret the results. Features Assists non-experts in this field design a test protocol and interpret the results Covers in vitro and in vivo aspects of interactions between drugs and light Explores the kinetic and chemical aspects of drug photodecomposition Discusses the problems frequently encountered in photochemical stability testing Provides guidance on how to address photosafety assessments and labeling requirements of potentially photoreactive drugs Highlights the practical implications of drug photodecomposition from a pharmaceutical viewpoint Offers specific guidance in photostability testing and screening of drug photoreactivity
Author: Hanne Hjorth Tonnesen
Publisher: CRC Press
ISBN: 074840449X
Category : Medical
Languages : en
Pages : 416
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Book Description
This text discusses various aspects of the combination of drugs and light. Degradation processes, stabilization of photolabile drug substances within formulations, benefits from the combination of drugs and light, and testing of drug photoreactivity, are some of the topics discussed.
Author: Steven W. Baertschi
Publisher: CRC Press
ISBN: 1439801800
Category : Medical
Languages : en
Pages : 626
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Book Description
The second edition of Pharmaceutical Stress Testing: Predicting Drug Degradation provides a practical and scientific guide to designing, executing and interpreting stress testing studies for drug substance and drug product. This is the only guide available to tackle this subject in-depth. The Second Edition expands coverage from chemical stability
Author: Jan F. Rabek
Publisher: Springer Science & Business Media
ISBN: 3642800904
Category : Science
Languages : en
Pages : 222
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Book Description
In this book on physical characteristics and practical aspects of polymer photodegradation Rabek emphasizes the experimental work on the subject. The most important feature of the book is the physical interpretation of polymer degradation, e.g. mechanism of UV/light absorption, formation of excited states, energy transfer mechanism, kinetics, dependence on physical properties of macromolecules and polymer matrices, formation of mechanical defects, practics during environmental ageing. He includes also some aspects of polymer photodegradation in environmental and space condition.
Author: P Suppan
Publisher: Royal Society of Chemistry
ISBN: 1847550436
Category : Science
Languages : en
Pages : 309
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Book Description
This text provides a concise introduction to all aspects of light-induced processes in chemistry, physics and biology, as well as in medicine and industry. It is up to date with the latest advances in the field, in particular the probing of the fastest light-induced reactions on picosecond and femtosecond time scales, and is based on the photochemistry and photophysics degree course devised by the author. Chemistry and Light is a must for final year undergraduates, as well as for post-graduate students. It will prove extremely useful for teachers in the preparation of courses and seminars and will provide essential background information for industrial chemists, in one complete source. The book reflects the enthusiasm the author has for his subject, as well as his talent for clear description. Chemistry and Light will be welcomed by students and research workers alike.
Author: Andrew Teasdale
Publisher: John Wiley & Sons
ISBN: 1118971132
Category : Medical
Languages : en
Pages : 624
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Book Description
Examining the implications and practical implementation of multi-disciplinary International Conference on Harmonization (ICH) topics, this book gives an integrated view of how the guidelines inform drug development strategic planning and decision-making. • Addresses a consistent need for interpretation, training, and implementation examples of ICH guidelines via case studies • Offers a primary reference point for practitioners addressing the dual challenge of interpretation and practical implementation of ICH guidelines • Uses case studies to help readers understand and apply ICH guidelines • Provides valuable insights into guidelines development, with chapters by authors involved in generating or with experience implementing the guidelines • Includes coverage of stability testing, analytical method validation, impurities, biotechnology drugs and products, and good manufacturing practice (GMP)
Author: Hanne Hjorth Tønnesen
Publisher:
ISBN: 9780131275645
Category :
Languages : en
Pages : 405
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Book Description
Author: Joseph T. Piechocki
Publisher: CRC Press
ISBN: 1420014137
Category : Medical
Languages : en
Pages : 472
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Book Description
Based on a training course developed by Dr. Joseph T. Piechocki and other experts in this field whose contributions appear in this book for two International Meetings on the Photostability of Drugs and Drug Products, this text clarifies the guidelines set by the International Conference on Harmonization (ICH) and provides a comprehensive background
Author: N. Anthony Armstrong
Publisher: CRC Press
ISBN: 9780203483091
Category : Medical
Languages : en
Pages : 294
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Book Description
This work provides a description of the principles of experimental design and their application to pharmaceutical research. It includes worked examples taken from a wide variety of pharmaceutical techniques and processes.
Author: Indra K. Reddy
Publisher: CRC Press
ISBN: 0824751094
Category : Science
Languages : en
Pages : 406
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Book Description
Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. It supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. Chirality in Drug Design and Development collects the latest studies from an interdisciplinary team of experts on chiral drug design.
