Photoreceptors and Calcium PDF Download
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Author: Wolfgang Baehr
Publisher: Springer Science & Business Media
ISBN: 1461501210
Category : Medical
Languages : en
Pages : 636
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Book Description
This volume foxuses on the status of Ca2+ ions in regulation of phototransduction, light adaptation and the recovery phase in vertebrate photoreceptors. Particular emphasis is given to Ca2+-binding proteins and their targets, among them particulate guanylate cyclases, GPCR-coupled kinases and cyclic nucleotide-gated cation channels. The book also expands our understanding of events invovling Ca2+ in the retinal pigment epithelium, in synaptic transmission and secondary retinal neurons. A significant part of the book is dedicated to the role of Ca2+ in invertebrate phototransduction, the best-studied phospholipid-mediated signal transduction pathway. Several chapters explore association of gene defects with human retina disease and the generation of animal models of retinal degeneration.
Author: Wolfgang Baehr
Publisher: Springer Science & Business Media
ISBN: 1461501210
Category : Medical
Languages : en
Pages : 636
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Book Description
This volume foxuses on the status of Ca2+ ions in regulation of phototransduction, light adaptation and the recovery phase in vertebrate photoreceptors. Particular emphasis is given to Ca2+-binding proteins and their targets, among them particulate guanylate cyclases, GPCR-coupled kinases and cyclic nucleotide-gated cation channels. The book also expands our understanding of events invovling Ca2+ in the retinal pigment epithelium, in synaptic transmission and secondary retinal neurons. A significant part of the book is dedicated to the role of Ca2+ in invertebrate phototransduction, the best-studied phospholipid-mediated signal transduction pathway. Several chapters explore association of gene defects with human retina disease and the generation of animal models of retinal degeneration.
Author: James Philip Younger
Publisher:
ISBN:
Category :
Languages : en
Pages : 274
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Book Description
Author: Kai Kaila
Publisher: John Wiley & Sons
ISBN: 9780471118381
Category : Medical
Languages : en
Pages : 694
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Book Description
"PH and Brain Function offers thorough coverage of this increasingly important area of research, beginning with the fundamental concepts, which include methodological and theoretical issues such as the measurement of pH and the concept of pH in neurobiology. It explores aspects of regulation and modulation of intracellular pH in brain cells, surveys the changes in pH that occur with neural activity and how these changes affect neural activity, and discusses the role of pH in the pathophysiology of neurological diseases." "pH and Brain Function is an important resource for researchers in all areas of neuroscience as well as cell biology and physiology." --Book Jacket.
Author: Helga Kolb
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Michel Félétou
Publisher: Morgan & Claypool Publishers
ISBN: 1615041230
Category : Science
Languages : en
Pages : 309
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Book Description
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Author: Johannes Christoph Oberwinkler
Publisher:
ISBN: 9789036712187
Category :
Languages : en
Pages : 152
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Book Description
Author: Celia Mary Bisbach
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Photoreceptors require an excessive amount of energy to carry out their function, yet their access to the nutrients and oxygen which could facilitate efficient ATP production is restricted by neighboring retinal pigment epithelial (RPE) cells. This dissertation investigates the metabolic adaptations made by both photoreceptors and RPE which allow both cell types to coexist in a competitive environment, with a focus on understanding the independent influences of mitochondrial Ca2+ uptake and O2 tension. Highly specialized photoreceptors in the retina use Ca2+ as a second messenger to transduce light to a chemical signal, yet we find that mitochondrial Ca2+uptake mediated by the Mitochondrial Ca2+ Uniporter is quite dispensable for photoreceptor metabolism and function. Instead, we find that photoreceptor metabolism appears to be programmed by the basal hypoxic niche they normally reside in, which causes photoreceptors produce succinate by non-canonical reversal of succinate dehydrogenase. This succinate is exported from retinas by Monocarboxylate Transporter 1 (MCT1) and is capable of being imported and oxidized by eyecup tissue, which has ample access to O2 in the eye. Transport of succinate between tissues may be more widespread than previously thought, as we also uncover evidence that succinate can be oxidized in cerebellum, kidney, liver, and brown adipose tissue.
Author: Ramakrishnan Ranganathan
Publisher:
ISBN:
Category :
Languages : en
Pages : 402
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Book Description
Author: Md. Shahidul Islam
Publisher: Springer Nature
ISBN: 3030124576
Category : Medical
Languages : en
Pages : 1110
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Book Description
This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to bacteria, fruit fly and zebrafish. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative. The chapter “Calcium Signaling: From Basic to Bedside” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author: Hugo J. Bellen
Publisher: Oxford University Press, USA
ISBN:
Category : Medical
Languages : en
Pages : 466
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Book Description
This book provides the reader with background information on neurotransmitter release. Emphasis is placed on the rationale by which proteins are assigned specific functions rather than just providing facts about function.
