Phosphorus NMR in Biology PDF Download
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Author: C. Burt
Publisher: CRC Press
ISBN: 1351092448
Category : Medical
Languages : en
Pages : 337
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Book Description
NMR is a technique that can spoil you. It is true that it is not as sensitive as some of the spectroscopic methods, but the quality of the information and the incredible ease of sample preparation make it one of the tools that have opened new vistas in biological research. This volume is intended to show how those vistas can range from the molecule to the microbe to man himself. Further, it is what prompts the rather broad title.
Author: C. Burt
Publisher: CRC Press
ISBN: 1351092448
Category : Medical
Languages : en
Pages : 337
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Book Description
NMR is a technique that can spoil you. It is true that it is not as sensitive as some of the spectroscopic methods, but the quality of the information and the incredible ease of sample preparation make it one of the tools that have opened new vistas in biological research. This volume is intended to show how those vistas can range from the molecule to the microbe to man himself. Further, it is what prompts the rather broad title.
Author: David G. Gorenstein
Publisher: Academic Press
ISBN: 0080918417
Category : Science
Languages : en
Pages : 619
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Book Description
Phosphorous-31 NMR: Principles and Applications focuses on the evolution of phosphorus-31 nuclear magnetic resonance (NMR) as a widely applied spectroscopic probe of the structure and dynamics of phosphorus-containing compounds. The selection first offers information on the principles and empirical observations of phosphorus-31 chemical shifts and the principles and applications of phosphorus-31 spin-spin coupling constants. Discussions focus on introduction and basic principles, directly bonded phosphorus coupling constants, and two-bond and three-bond coupling constants. The text then ponders on phosphorus-31 NMR of enzyme complexes and paramagnetic probes of enzyme complexes with phosphorus-containing compounds. The manuscript elaborates on the use of chiral thiophosphates and the stereochemistry of enzymatic phosphoryl transfer and DNA and RNA conformations. Topics include helix-coil transitions, sequence dependence of double-stranded DNA conformations, dynamic behavior of RNA and DNA, biological and genetic significance, and stereochemical problems studied with chiral thiophosphates. The conformation and dynamics of nucleic acids and phosphoproteins, relaxation behavior of nucleic acids, and theory and applications of solid-state phosphorus-31 NMR to nucleic acids are also discussed. The selection is a valuable reference for readers interested in the principles and applications of phosphorus-31 nuclear magnetic resonance.
Author: John L. Markley
Publisher: Oxford University Press
ISBN: 0195357426
Category : Science
Languages : en
Pages : 375
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Book Description
This book presents a critical assessment of progress on the use of nuclear magnetic resonance spectroscopy to determine the structure of proteins, including brief reviews of the history of the field along with coverage of current clinical and in vivo applications. The book, in honor of Oleg Jardetsky, one of the pioneers of the field, is edited by two of the most highly respected investigators using NMR, and features contributions by most of the leading workers in the field. It will be valued as a landmark publication that presents the state-of-the-art perspectives regarding one of today's most important technologies.
Author: Thomas C. Pochapsky
Publisher: Garland Science
ISBN: 1136843728
Category : Science
Languages : en
Pages : 372
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Book Description
Nuclear Magnetic Resonance spectroscopy is a dynamic way for scientists of all kinds to investigate the physical, chemical, and biological properties of matter. Its many applications make it a versatile tool previously subject to monolithic treatment in reference-style texts. Based on a course taught for over ten years at Brandeis University, this is the first textbook on NMR spectroscopy for a one-semester course or self-instruction. In keeping with the authors' efforts to make it a useful textbook, they have included problems at the end of each chapter. The book not only covers the latest developments in the field, such as GOESY (Gradient Enhanced Overhauser Spectroscopy) and multidimensional NMR, but includes practical examples using real spectra and associated problem sets. Assuming the reader has a background of chemistry, physics and calculus, this textbook will be ideal for graduate students in chemistry and biochemistry, as well as biology, physics, and biophysics. NMR for Physical and Biological Scientists will also be useful to medical schools, research facilities, and the many chemical, pharmaceutical, and biotech firms that offer in-house instruction on NMR spectroscopy.
Author: David G. Gorenstein
Publisher:
ISBN: 9780080310176
Category :
Languages : en
Pages : 98
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Book Description
Author: Olaf Kühl
Publisher: Springer Science & Business Media
ISBN: 3540791183
Category : Science
Languages : en
Pages : 138
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Book Description
Nuclear Magnetic Resonance is a powerful tool, especially for the identification of 1 13 hitherto unknown organic compounds. H- and C-NMR spectroscopy is known and applied by virtually every synthetically working Organic Chemist. Con- quently, the factors governing the differences in chemical shift values, based on chemical environment, bonding, temperature, solvent, pH, etc. , are well understood, and specialty methods developed for almost every conceivable structural challenge. Proton and carbon NMR spectroscopy is part of most bachelors degree courses, with advanced methods integrated into masters degree and other graduate courses. In view of this universal knowledge about proton and carbon NMR spectr- copy within the chemical community, it is remarkable that heteronuclear NMR is still looked upon as something of a curiosity. Admittedly, most organic compounds contain only nitrogen, oxygen, and sulfur atoms, as well as the obligatory hydrogen and carbon atoms, elements that have an unfavourable isotope distribution when it comes to NMR spectroscopy. Each of these three elements has a dominant isotope: 14 16 32 16 32 N (99. 63% natural abundance), O (99. 76%), and S (95. 02%), with O, S, and 34 14 S (4. 21%) NMR silent. N has a nuclear moment I = 1 and a sizeable quadrupolar moment that makes the NMR signals usually very broad and dif cult to analyse.
Author: W. J. Stec
Publisher: Elsevier
ISBN: 148315128X
Category : Science
Languages : en
Pages : 240
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Book Description
Phosphorus Chemistry Directed Towards Biology presents an understanding of reaction mechanisms of organophosphorus compounds. This book discusses the development of analytical tools for the study of the chemistry of phosphorus, which promoted research in nucleic acid chemistry. Organized into 22 chapters, this book begins with an overview of the importance of the bacterial cell wall in maintaining the integrity of the cell in various environments. This text then examines the chemical problems concerning hypermodification and deprotection steps. Other chapters consider the reactive phosphorylating intermediates used in the oligonucleotide chemistry. This book discusses as well the possible role of phosphodiester triazolides and tetrazolides in the phosphotriester formation with arenesulfonyltriazolides and tetrazolides. The final chapter deals with the isolation of proteins involved in the synthesis and recognition of mRNA caps. This book is a valuable resource for phosphorus chemists, biologists, scientists, research workers, teachers, and students.
Author: Louis D. Quin
Publisher: VCH Publishers
ISBN:
Category : Science
Languages : en
Pages : 484
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Book Description
Presents advances in 31P NMR and coupling effects of the past six years (since VCH published its first jointly edited monograph on the subject). A wide cross-section of experts contribute a concise account of their use of 31P NMR in their own area of expertise, giving major emphasis to the research results they have obtained since the earlier monograph appeared. The volume is divided into nine sections: chemical shift theory; conformational analysis of phosphorus-containing ring systems; compounds with three-, four-, and five-coordinate phosphorus; low-coordinate phosphorus compounds; metal complexes of phosphorus ligands; biological phosphorus systems; mechanism elucidation in phosphorus chemistry; analytical and interpretive aspects; and NMR with solid phosphorus-containing systems. Annotation copyright by Book News, Inc., Portland, OR
Author: Kurt Wuthrich
Publisher: World Scientific
ISBN: 9814500496
Category : Science
Languages : en
Pages : 760
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Book Description
The volume presents a survey of the research by Kurt Wüthrich and his associates during the period 1965 to 1994. A selection of reprints of original papers on the use of NMR spectroscopy in structural biology is supplemented with an introduction, which outlines the foundations and the historical development of the use of NMR spectroscopy for the determination of three-dimensional structures of biological macromolecules in solution. The original papers are presented in groups highlighting protein structure determination by NMR, studies of dynamic properties and hydration of biological macromolecules, and practical applications of the NMR methodology in fields such as enzymology, transcriptional regulation, immunosuppression and protein folding.
Author: Neil E. Jacobsen
Publisher: John Wiley & Sons
ISBN: 0470173343
Category : Science
Languages : en
Pages : 640
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Book Description
NMR Spectroscopy Explained : Simplified Theory, Applications and Examples for Organic Chemistry and Structural Biology provides a fresh, practical guide to NMR for both students and practitioners, in a clearly written and non-mathematical format. It gives the reader an intermediate level theoretical basis for understanding laboratory applications, developing concepts gradually within the context of examples and useful experiments. Introduces students to modern NMR as applied to analysis of organic compounds. Presents material in a clear, conversational style that is appealing to students. Contains comprehensive coverage of how NMR experiments actually work. Combines basic ideas with practical implementation of the spectrometer. Provides an intermediate level theoretical basis for understanding laboratory experiments. Develops concepts gradually within the context of examples and useful experiments. Introduces the product operator formalism after introducing the simpler (but limited) vector model.
