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Author: Han-Ting Zhang
Publisher: Springer
ISBN: 3319588117
Category : Medical
Languages : en
Pages : 475
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Book Description
PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.
Author: Han-Ting Zhang
Publisher: Springer
ISBN: 3319588117
Category : Medical
Languages : en
Pages : 475
Get Book Here
Book Description
PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.
Author: Xiaodong C. Cheng
Publisher: CRC Press
ISBN:
Category : Cellular signal transduction
Languages : en
Pages : 264
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Book Description
Author: Suresh C Sikka
Publisher: Academic Press
ISBN: 0128013133
Category : Medical
Languages : en
Pages : 638
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Book Description
Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health is structured into two parts related to men's reproductive and sexual health with eight sections designed to enable a logical flow of such knowledge. The book is focused on the biology of key organs involved in male reproduction and the environmental influences affecting their functions with particular emphasis on clinical aspects. Individual chapters within the book range from basic to translational aspects, but all hold clinical relevance. This is an essential reference for those working and learning in the field of human reproduction, reproductive toxicology and environmental influences on reproductive and sexual health. - Brings together the leading authorities working in the field of male reproduction and sexual health and how the environment affects these issues - Provides guidelines and reference values of various reproductive hormones, semen parameters, inclusion/exclusion criteria for clinical trials - Discover the most efficient methods by which to design clinical protocols for sperm safety studies and reproductive toxicology trials
Author: David G. Lichter
Publisher: Guilford Press
ISBN: 9781572306233
Category : Psychology
Languages : en
Pages : 474
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Book Description
The authors review knowledge on the anatomy of the frontal-subcortical circuits, their connections to other brain regions, and their influences on motor, cognitive, affective, and behavioral functioning. Specific clinical problems are addressed, including Parkinson's disease, obsessive/compulsive disorder, ADHD, and more. of full-color illustrations.
Author: Gonzalo Emiliano Aranda Abreu
Publisher: BoD – Books on Demand
ISBN: 9535134515
Category : Medical
Languages : en
Pages : 320
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Book Description
"Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.
Author: Ulla Kopp
Publisher: Morgan & Claypool Publishers
ISBN: 1615042318
Category : Medical
Languages : en
Pages : 99
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Book Description
The kidney is innervated with efferent sympathetic nerve fibers reaching the renal vasculature, the tubules, the juxtaglomerular granular cells, and the renal pelvic wall. The renal sensory nerves are mainly found in the renal pelvic wall. Increases in efferent renal sympathetic nerve activity reduce renal blood flow and urinary sodium excretion by activation of α1-adrenoceptors and increase renin secretion rate by activation of β1-adrenoceptors. In response to normal physiological stimulation, changes in efferent renal sympathetic nerve activity contribute importantly to homeostatic regulation of sodium and water balance. The renal mechanosensory nerves are activated by stretch of the renal pelvic tissue produced by increases in renal pelvic tissue of a magnitude that may occur during increased urine flow rate. Activation of the sensory nerves elicits an inhibitory renorenal reflex response consisting of decreases in efferent renal sympathetic nerve activity leading to natriuresis. Increasing efferent sympathetic nerve activity increases afferent renal nerve activity which, in turn, decreases efferent renal sympathetic nerve activity by activation of the renorenal reflexes. Thus, activation of the afferent renal nerves buffers changes in efferent renal sympathetic nerve activity in the overall goal of maintaining sodium balance. In pathological conditions of sodium retention, impairment of the inhibitory renorenal reflexes contributes to an inappropriately increased efferent renal sympathetic nerve activity in the presence of sodium retention. In states of renal disease or injury, there is a shift from inhibitory to excitatory reflexes originating in the kidney. Studies in essential hypertensive patients have shown that renal denervation results in long-term reduction in arterial pressure, suggesting an important role for the efferent and afferent renal nerves in hypertension. Table of Contents: Part I: Efferent Renal Sympathetic Nerves / Introduction / Neuroanatomy / Neural Control of Renal Hemodynamics / Neural Control of Renal Tubular Function / Neural Control of Renin Secretion Rate / Part II: Afferent Renal Sensory Nerves / Introduction / Neuroanatomy / Renorenal Reflexes / Mechanisms Involved in the Activation of Afferent Renal Sensory Nerves / Part III: Pathophysiological States / Efferent Renal Sympathetic Nerves / Afferent Renal Sensory Nerves / Conclusions / References
Author: Joseph A. Beavo
Publisher: CRC Press
ISBN: 1420020846
Category : Medical
Languages : en
Pages : 766
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Book Description
Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph
Author: Nicholas J. Brandon
Publisher: John Wiley & Sons
ISBN: 1118836308
Category : Medical
Languages : en
Pages : 429
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Book Description
This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.
Author: Francisco Lopez-Munoz
Publisher: CRC Press
ISBN: 143983850X
Category : Medical
Languages : en
Pages : 521
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Book Description
Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, mol
Author: Jean Louis Imbs
Publisher: Pergamon
ISBN:
Category : Medical
Languages : en
Pages : 428
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Book Description
Peripheral Dopaminergic Receptors contains the proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology held in Strasbourg, France, on July 24-25, 1978. The papers explore advances that have been made in understanding peripheral dopaminergic receptors and cover topics organized around five themes: dopamine measurement; structure-activity relationships; peripheral actions of dopamine; effects of dopamine on the kidney; and the physiological role of dopamine in the autonomic nervous system. This volume is comprised of 36 chapters and opens with a discussion on the ...
