PHARMACOLOGY OF GANGLIONIC TRANSMISSION (Volume 53). PDF Download
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Author: DA KHARKEVICH (Ed)
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: DA KHARKEVICH (Ed)
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: D.A. Kharkevich
Publisher: Springer Science & Business Media
ISBN: 364267397X
Category : Medical
Languages : en
Pages : 536
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D.A. KHARKEVICH The history of the study of ganglionic substances begins with the paper of LANGLEY and DICKINSON (1889), who established the ability of nicotine to block the neurones in the superior cervical ganglion. This was a considerable discovery as the authors ascertained that impulses were transmitted from pre- to postganglionic neurones in the autonomic ganglia. Simultaneously they indicated the possibility of pharmaco logical influence upon interneuronal transmission in autonomic ganglia. The idea of ganglionic receptors specifically sensitive to nicotine followed logically. Later, LANGLEY (1905, 1906) considered the problem of receptors with respect to neuro-effector synapses. It is remarkable that he was one of the first to put forward the theory of chemical mediation of excitation (" ... the nervous impulse should not pass from nerve to muscle by an electric discharge, but by the secretion of a special substance at the end of the nerve": LANGLEY, 1906, p. 183). In addition, LANGLEY JOHN N. LANGLEY (1852-1926) D.A. KHARKEVICH 2 and his collaborators managed to define the topography of autonomic ganglia more precisely by means of nicotine. It should be mentioned that it was he who introduced the terms "autonomic nervous system" and "parasympathetic nervous system".
Author: Michael A. Bray
Publisher: Springer Science & Business Media
ISBN: 3642732178
Category : Medical
Languages : en
Pages : 633
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"Immunopharmacology" , why not "pharmacoimmunology"? Professor H. O. Schild University College London, 1962 An intact immune response is essential for survival, as is evidenced by the various innate immune deficiency syndromes and by the emergence of the acquired immune deficiency syndrome (AIDS) as a pandemic during the last decade. Substances which stimulate the immune response might contribute to the therapy of AIDS and its precursor, AIDS-related syndrome, as well as of other clinical conditions in which immune responses can be diminished, such as carcinoma and infections. In other circumstances, an intact or heightened immune response may pose clinical problems; hence there is need to suppress, or diminish, components of the immune response. For instance, it is necessary to impair cellular immunity in order to ensure lasting acceptance of heterografts and it is already established that agents effective in transplantation are therapeutically effective in an range of autoimmune diseases. More recently, experimental studies have indicated that aberrant manifestations of humoral immunity, as in allergies, may also be amenable to pharmacological intervention.
Author: P.A. Van Zwieten
Publisher: Elsevier
ISBN: 148325724X
Category : Medical
Languages : en
Pages : 386
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Handbook of Hypertension, Volume 3: Pharmacology of Antihypertensive Drugs presents the biological and clinical knowledge in the field of hypertension. This book discusses the fundamental pharmacology of antihypertensive drugs. Organized into 12 chapters, this volume begins with an overview of the classification of antihypertensive mechanisms of drugs. This text then examines the effects of antihypertensive drugs in animal models and discusses the importance of these models and responses to human hypertension. Other chapters consider the pharmacological basis for the treatment of hypertension. This book discusses as well the various classes of antihypertensive drugs, which depends on two factors. The final chapter deals with the inhibitors of angiotensin-converting enzyme, which are essential in the drug treatment of hypertensive disease. This book is a valuable resource for clinicians, pharmacists, physiologists, epidemiologists, biological scientists, and general practitioners. Clinical investigators and medical students will also find this book extremely useful.
Author: Kenneth J Broadley
Publisher: CRC Press
ISBN: 1135741387
Category : Medical
Languages : en
Pages : 630
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Book Description
This overview of autonomic pharmacology describes the anatomy, physiology and pharmacology of the autonomic involuntary nervous system. Covering the diverse group of drugs acting on the autonomous nervous system, their actions are reviewed together with their clinical uses, side effects, interactions and subcellular mechanisms of action. Information is organized in a logical flow, bringing together the latest advances in an integrated form on topics usually found only in a fragmented form.; This work is intended for all those researching in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry and molecular biology.
Author:
Publisher: Springer Science & Business Media
ISBN: 3642740545
Category : Medical
Languages : en
Pages : 602
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Book Description
The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin as in animal models, where they may be more relevant to human physiology and disease. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of aetiology and mechanism. For example, whilst the argument continued un resolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis retinoic acid, was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on aetiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as for the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.
Author: Laszlo Gyermek
Publisher: CRC Press
ISBN: 9780849385599
Category : Medical
Languages : en
Pages : 526
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Book Description
The theoretical and practical significance of antimuscarinic drugs is more obvious today than ever before. Antimuscarinics have helped to explore the pathomechanisms of of Alzheimer's disease, and to treat the symptoms of Parkinson's, cardiovascular problems, gastrointestinal diseases, and even nerve gas poisoning. No other drug class can claim as long a history with so many therapeutic applications, yet the most significant developments in this broad chapter of pharmacology come from the discovery of different muscarinic receptor sites in the peripheral and central nervous system and from the availability of many new selective agents, notably antagonists, for these different receptor types. Pharmacology of Antimuscarinic Agents, written by an expert in anesthesiology and drug research, focuses on the basic principles of antimuscarinic drugs, their therapeutic value, how they work, and what versions are now available in the U.S. and abroad. This is the first time in decades an author has reviewed historical and current literature to present a comprehensive, standard reference on the antimuscarinic family.
Author: Victor P. Whittaker
Publisher: Springer Science & Business Media
ISBN: 3642732208
Category : Medical
Languages : en
Pages : 766
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One of the most impressive works of scholarship in the field of experimental pharmacology has been the Heffter-Heubner Handbuch der experimentellen Pharmakologie, internationalized some years ago under the title Handbook 0/ Experimental Pharmacology and kept up to date by a series of numbered Ergiin zungswerke or supplementary volumes which have now replaced in importance the original Handbuch. These volumes constitute a valuable and continuously up dated multi author review series of topics important in modern pharmacology and allied sciences. The Editorial Board of the Handbook invited me 2 years ago to undertake, as subeditor, the preparation of a new volume entitled The Cholinergic Synapse. A previous volume in this series, vol. 15, Cholinesterases and Anticholinesterase Agents, edited by GEORGE KOELLE, was published in 1963 and was far wider in scope than its title suggested: it was, in fact an authoritative summing up of the whole subject of cholinergic function and still has some value today as an account of the state of the art as it was at that time. Since then another excellent review, of a specific cholinergic synapse, has appeared in this series: this was vol. 42, Neuromuscular Junction, edited by ELEANOR ZAIMIS and published in 1976. A third volume, vol. 53, Pharmacology o/Ganglionic Transmission, which appeared in 1980 and was edited by D. A. KHARKEVICH, includes important aspects of autonomic cholinergic function.
Author: H. P. Rang
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 868
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Book Description
Pharmacology is now firmly established as a world wide best-selling and highly acclaimed textbook for medical and science students. Its successful approach emphasies the mechanisms by which drugs act and relates these to the overall pharmacological effects and clinical uses. It sets out for the reader a clear route from a molecular understanding of receptors and drug actions, to the therapeutic uses of the most important groups of drugs. For the Fifth Edition the text has been completely updated, incorporating significant new information published in the last few years, while obsolete material has been removed. New agents are fully discussed as well as extensions of basic knowledge which presage further drug development. Book jacket.
