Advances in General and Cellular Pharmacology PDF Download
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Author: Toshio Narahashi
Publisher: Springer Science & Business Media
ISBN: 1461581982
Category : Medical
Languages : en
Pages : 262
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Book Description
Knowledge of the mechanism of action of drugs at cellular, subcellular, or molecular levels is of vital importance not only in giving the basis of inter pretation of the systemic action of drugs but also in improving existing drugs; in designing new forms of drugs; and in giving the basis of therapeutic applications. Classical pharmacology, concerning the action of drugs at integrated levels, does not necessarily give sufficient information as to the mechanism of action of drugs. A variety of sophisticated concepts utilizing the methods of physics, chemistry, biophysics, biochemistry, and physiology must be synthesized to understand the mechanism of action. Only since the last decade, however, have these techniques been fully applied to pharma cological investigations. It is of utmost importance to realize that a new dimension of pharmacological research has indeed emerged as a result of such a multidisciplinary approach; this approach is encompassed in general and cellular pharmacology. Such recent studies of drug actions have led to a number of important findings. Certain chemicals and drugs were found to possess highly specific actions on cellular functions, so that they are widely being used as powerful tools for the study of a variety of physiological and pharmacological prob lems. Our knowledge of the cellular mechanisms of drug action has provided the basis for interpreting the systemic effects of the drugs and insight into the molecular mechanism involved.
Author: Francesco Clementi
Publisher: John Wiley & Sons
ISBN: 1118768574
Category : Medical
Languages : en
Pages : 784
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Book Description
With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, and all figures and tables from the book
Author: A.J. Clark
Publisher: Springer
ISBN: 9783642896071
Category : Medical
Languages : en
Pages : 0
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Book Description
The author's general aim has been to survey as wide a field of evidence as possible and this had involved excursions into subjects of which he has little first hand knowledge. This width of range also has necessitated a somewhat arbitrary selection of evidence and has prevented full discussion of any indi vidual problem. The author trusts that he has not misrepresented anyone's results or opinions, and if this has occurred, he can only plead in excuse the peculiar difficulty of giving a brief and yet accurate account of evidence of such a wide variety. The diagrams reproduced in the article have all been redrawn and in many cases the original figures or diagrams have been modified as, for instance, by recalculating dosage on the logarithmic scale. The original authors therefore have no direct responsibility for the diagrams in their present form. The author desires to thank Messrs Arnold and Co. for permitting the repro duction of Figs. 9 and 23 from similar figures which appeared in his book "The Mode of Action of Drugs on Cells"; portions of other figures from this book also have been reproduced in modified form. The author also desires to thank Dr. J. M. ROBSON for help in correction of the proofs. Edinburgh, July, 1937. A. J. CLARK. Contents.
Author: Toshio Narahashi
Publisher: Springer Science & Business Media
ISBN: 1461581982
Category : Medical
Languages : en
Pages : 262
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Book Description
Knowledge of the mechanism of action of drugs at cellular, subcellular, or molecular levels is of vital importance not only in giving the basis of inter pretation of the systemic action of drugs but also in improving existing drugs; in designing new forms of drugs; and in giving the basis of therapeutic applications. Classical pharmacology, concerning the action of drugs at integrated levels, does not necessarily give sufficient information as to the mechanism of action of drugs. A variety of sophisticated concepts utilizing the methods of physics, chemistry, biophysics, biochemistry, and physiology must be synthesized to understand the mechanism of action. Only since the last decade, however, have these techniques been fully applied to pharma cological investigations. It is of utmost importance to realize that a new dimension of pharmacological research has indeed emerged as a result of such a multidisciplinary approach; this approach is encompassed in general and cellular pharmacology. Such recent studies of drug actions have led to a number of important findings. Certain chemicals and drugs were found to possess highly specific actions on cellular functions, so that they are widely being used as powerful tools for the study of a variety of physiological and pharmacological prob lems. Our knowledge of the cellular mechanisms of drug action has provided the basis for interpreting the systemic effects of the drugs and insight into the molecular mechanism involved.
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1042
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Book Description
Author: Johannes Carl Bock
Publisher: Springer-Verlag
ISBN: 3662286416
Category : Medical
Languages : de
Pages : 236
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 512
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Author:
Publisher: Anthony Daccache
ISBN:
Category : Business & Economics
Languages : fr
Pages : 106
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Book Description
Définition de la pharmacologie: La pharmacologie (du grec φά ρ μ ακ ο ν , pharmakon [médicament] et -λ ο γ ί α, - logia [mots]) est la science qui a pour objet l’étude des médicaments. C’est une discipline qui réunie la pharmacie, la chimie, la biologie, la génétique, la pathologie, la thérapeutique et d’autres sciences. 3 Grands principes de pharmacologie médicale L’Organisation Mondiale de la Santé (OMS) définit la pharmacologie clinique comme l’ensemble des activités liées au devenir et aux effets des médicaments chez l’homme ainsi qu’à leur usage: 1° Pharmacodynamie : étude des réponses à l’administration des substances 2° Essais cliniques : évaluation de l’efficacité des médicaments 3° Pharmacocinétique: étude du devenir des médicaments dans l’organisme 4° Pharmacovigilance: détection, évaluation, compréhension et prévention des risques d’effets indésirables des médicaments après la commercialisation du médicament 5° Pharmacodépendance: détection, évaluation, surveillance du potentiel 4 addictif des médicaments et substances licites. Grands principes de pharmacologie médicale 6° Pharmacoéconomie: évaluation des conséquences médicoéconomiques attribuables à l’usage d’un médicament 7°Pharmacoépidémiologie: caractérisation de l’utilisation des médicaments dans les différentes populations ou groupes sociaux 8° Aide à la prescription et informations sur le médicament : conseil sur les modalités individuelles d’utilisation du médicament 5 Importance de la pharmacologie A quoi sert la pharmacologie ? L
Author: T. Z. Csáky
Publisher:
ISBN:
Category : Pharmacology
Languages : en
Pages : 249
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Author:
Publisher:
ISBN:
Category : Family medicine
Languages : en
Pages : 620
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