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Author: Alberta Hoi
Publisher: Springer Nature
ISBN: 3030851613
Category : Medical
Languages : en
Pages : 192
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Book Description
The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.
Author: Alberta Hoi
Publisher: Springer Nature
ISBN: 3030851613
Category : Medical
Languages : en
Pages : 192
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Book Description
The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.
Author: Syuichi Koarada
Publisher: Nova Science Publishers
ISBN: 9781628089905
Category : Medical
Languages : en
Pages : 0
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Book Description
Systemic lupus erythematosus (SLE) is one of the prototypical systemic autoimmune diseases characterised by inflammation, immune complex deposition, and vasculitis. Patients with SLE show various symptoms and clinical images, both constitutional and specific organ symptoms. They include the skin, joints, muscles, kidneys, lungs, nervous system, and blood vessels. Although the aetiology of the disease is still unclear, genetic, hormonal, immunologic abnormalities and environmental factors complicatedly play important roles in the pathophysiology in SLE. It is evident that multiple genes show genetic susceptibility to SLE. Environmental factors of SLE and immunologic abnormalities, especially the production of a number of auto-antibody, are important features of the disease. In this book, we present recent knowledge about the prevalence, pathophysiology and prognosis of SLE. The book includes various interesting chapters: Chapter One: An illustrated overview of the prevalence and clinical symptoms of systemic lupus erythematosus; Chapter Two: Pathophysiology of systemic lupus erythematosus; Chapter Three: MBL and MBL genotypes in SLE; Chapter Four: Novel biological activities of autoantibodies as the potential markers of systematic lupus erythematosus; Chapter Five: Cytokines in systemic lupus erythematosus (sle) with clinical aspects and prognostics; Chapter Six: Prognosis in systemic lupus erythematosus; Chapter Seven: Auto-antibody-producing RP105-negative B cells in humans and a murine model of lupus erythematosus.
Author: Caroline Gordon
Publisher: Oxford University Press
ISBN: 0198739184
Category : Medical
Languages : en
Pages : 161
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Book Description
Systemic Lupus Erythematosus provides a practical approach to the assessment and management of patients with this complex, multisystem autoimmune disease to improve the diagnosis and treatment of the disease and its complications.
Author: Peter H. Schur
Publisher: Springer Science & Business Media
ISBN: 1461411890
Category : Medical
Languages : en
Pages : 266
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Book Description
Often considered the prototypic autoimmune disease, Lupus is characterized by protean manifestations and affects a wide range of organ systems. Despite widespread availability of anti nuclear antibody testing and other technological diagnostic advances, the diagnosis of lupus can be elusive, difficult, and inexact. Treatment of the disease can also be challenging. Advances in immunology and biotechnology have led to a burgeoning world of new therapies in development that offer patients the real possibility of new therapies and physicians and scientists novel insights into the pathogenesis of this complicated immunological disease. Lupus Erythematosus: Clinical Evaluation and Treatment summarizes the clinical aspects of lupus facing the general clinician in the 21st century. In this invaluable, practical book, the reader will find introductory chapters regarding general diagnostic and treatment principles, followed by chapters addressing the lupus-specific organ manifestations. Special topics regarding pregnancy and comorbidities are also presented. Written by highly experienced physicians with special expertise in lupus, Lupus Erythematosus: Clinical Evaluation and Treatment is an indispensable reference for the common and not so common problems affecting patients with lupus.
Author: Daniel Wallace
Publisher: Elsevier Health Sciences
ISBN: 0323550649
Category : Medical
Languages : en
Pages : 752
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Book Description
For more than 50 years, Dubois’ Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It’s an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes. Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients. Offers an increased focus on the clinical management of related disorders such as Sjogren’s syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS). Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment. Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout.
Author: Rolando Cimaz
Publisher: Elsevier
ISBN: 0080553443
Category : Medical
Languages : en
Pages : 301
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Book Description
Many of the systemic autoimmune diseases seen in children are different from those seen in adults making them a special problem for physicians and scientists who care for the affected children and study their diseases. Benefiting both pediatric and adult rheumatologists, as well as physicians from other specialties, this volume covers the latest advances in pathogenesis and clinical management of common conditions seen in pediatric rheumatology practices.
Author: John B. Imboden
Publisher: McGraw-Hill/Appleton & Lange
ISBN:
Category : Medical
Languages : en
Pages : 532
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Book Description
An ideal quick reference for primary care providers, specialists, and trainees, this accessible resource offers up-to-date assessment and management solutions for the entire range of rheumatologic diseases.
Author: Gary M. Kammer
Publisher: Springer Science & Business Media
ISBN: 1592597033
Category : Medical
Languages : en
Pages : 727
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Book Description
Leading basic and clinical investigators from around the world summarize the most recent research on the molecular and cellular origins of lupus. Their cutting-edge articles review the mechanisms underlying abnormal immunity and introduce the powerful new concept that a disorder of multiple genes underlies the abnormal immune response, leading directly to the development of lupus. This pathophysiology is shown to involve a wide variety of cell types, including T cells, B cells, natural killer cells, macrophages/monocytes, and endothelial cells. Over time, the resulting long-term inflammation causes irreversible cell destruction and, ultimately, organ failure. Lupus: Molecular and Cellular Pathogenesis is a masterful new synthesis of all the new knowledge emerging today about lupus. Its new perspectives will sharpen the focus of research and ultimately lead to better and more effective treatment.
Author: René Mauricio Barría
Publisher:
ISBN: 1789236940
Category : Cohort analysis
Languages : en
Pages : 73
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Book Description
Author: Qingjun Pan
Publisher: Frontiers Media SA
ISBN: 2889767027
Category : Medical
Languages : en
Pages : 126
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Book Description
