Pandemic Influenza Vaccine Approaches: Current Status and Future Directions

Pandemic Influenza Vaccine Approaches: Current Status and Future Directions PDF Author: Rebecca Jane Cox
Publisher: Frontiers Media SA
ISBN: 2832501036
Category : Medical
Languages : en
Pages : 156

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Book Description

Pandemic Influenza Vaccine Approaches: Current Status and Future Directions

Pandemic Influenza Vaccine Approaches: Current Status and Future Directions PDF Author: Rebecca Jane Cox
Publisher: Frontiers Media SA
ISBN: 2832501036
Category : Medical
Languages : en
Pages : 156

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Book Description


Vaccines for Pandemic Influenza

Vaccines for Pandemic Influenza PDF Author: Richard W Compans
Publisher: Springer
ISBN: 9783540921660
Category : Medical
Languages : en
Pages : 512

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Book Description
Recent years have seen unprecedented outbreaks of avian influenza A viruses. In particular, highly pathogenic H5N1 viruses have not only resulted in widespread outbreaks in domestic poultry, but have been transmitted to humans, resulting in numerous fatalities. The rapid expansion in their geographic distribution and the possibility that these viruses could acquire the ability to spread from person to person raises the risk that such a virus could cause a global pandemic with high morbidity and mortality. An effective influenza vaccine represents the best approach to prevent and control such an emerging pandemic. However, current influenza vaccines are directed at existing seasonal influenza viruses, which have little or no antigenic relationship to the highly pathogenic H5N1 strains. Concerns about pandemic preparedness have greatly stimulated research activities to develop eff- tive vaccines for pandemic influenza viruses, and to overcome the limitations inh- ent in current approaches to vaccine production and distribution. These limitations include the use of embryonated chicken eggs as the substrate for vaccine prod- tion, which is time-consuming and could involve potential biohazards in growth of new virus strains. Other limitations include the requirement that the current inac- vated influenza vaccines be administered using needles and syringes, requiring trained personnel, which could be a bottleneck when attempting to vaccinate large populations in mass campaigns. In addition, the current inactivated vaccines that are delivered by injection elicit limited protective immunity in the upper respiratory tract where the infection process is initiated.

History of Vaccine Development

History of Vaccine Development PDF Author: Stanley A. Plotkin
Publisher: Springer Science & Business Media
ISBN: 1441913394
Category : Medical
Languages : en
Pages : 352

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Book Description
Vaccinology, the concept of a science ranging from the study of immunology to the development and distribution of vaccines, was a word invented by Jonas Salk. This book covers the history of the methodological progress in vaccine development and to the social and ethical issues raised by vaccination. Chapters include "Jenner and the Vaccination against Smallpox," "Viral Vaccines," and "Ethical and Social Aspects of vaccines." Contributing authors include pioneers in the field, such as Samuel L. Katz and Hilary Koprowski. This history of vaccines is relatively short and many of its protagonists are still alive. This book was written by some of the chief actors in the drama whose subject matter is the conquest of epidemic disease.

The Threat of Pandemic Influenza

The Threat of Pandemic Influenza PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309095042
Category : Medical
Languages : en
Pages : 431

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Book Description
Public health officials and organizations around the world remain on high alert because of increasing concerns about the prospect of an influenza pandemic, which many experts believe to be inevitable. Moreover, recent problems with the availability and strain-specificity of vaccine for annual flu epidemics in some countries and the rise of pandemic strains of avian flu in disparate geographic regions have alarmed experts about the world's ability to prevent or contain a human pandemic. The workshop summary, The Threat of Pandemic Influenza: Are We Ready? addresses these urgent concerns. The report describes what steps the United States and other countries have taken thus far to prepare for the next outbreak of "killer flu." It also looks at gaps in readiness, including hospitals' inability to absorb a surge of patients and many nations' incapacity to monitor and detect flu outbreaks. The report points to the need for international agreements to share flu vaccine and antiviral stockpiles to ensure that the 88 percent of nations that cannot manufacture or stockpile these products have access to them. It chronicles the toll of the H5N1 strain of avian flu currently circulating among poultry in many parts of Asia, which now accounts for the culling of millions of birds and the death of at least 50 persons. And it compares the costs of preparations with the costs of illness and death that could arise during an outbreak.

Pandemic Influenza Preparedness and Response

Pandemic Influenza Preparedness and Response PDF Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241547685
Category : Medical
Languages : en
Pages : 62

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Book Description
This guidance is an update of WHO global influenza preparedness plan: the role of WHO and recommendations for national measures before and during pandemics, published March 2005 (WHO/CDS/CSR/GIP/2005.5).

Adverse Effects of Vaccines

Adverse Effects of Vaccines PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309214351
Category : Medical
Languages : en
Pages : 894

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Book Description
In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.

Disease Control Priorities, Third Edition (Volume 9)

Disease Control Priorities, Third Edition (Volume 9) PDF Author: Dean T. Jamison
Publisher:
ISBN: 9781464805271
Category : Health & Fitness
Languages : en
Pages : 0

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Book Description
Annotation This volume discusses health system policies (including financing global health, quality of care, and strengthening regulatory systems in low- and middle-income countries), as well as the methods and resources used throughout all DCP3 volumes.

Crisis and Emergency Risk Communication

Crisis and Emergency Risk Communication PDF Author: Barbara Reynolds
Publisher: CreateSpace
ISBN: 9781470193294
Category : Business & Economics
Languages : en
Pages : 278

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Book Description
Originally designed for communicating public health information associated with communicable diseases, this book covers essential topics concerning media relations for public and private sector public information officers. Topics include: Introduction to Crisis and Emergency Risk Communication-Types of crisis and communications during a crisis, the risk of disaster, emergency/crisis/risk communications, the crisis communications lifecycle-pre-crisis phase, initial phase, crisis maintenance, resolution, and evaluation. Psychology of a Crisis-Human behavior in an emergency, decision making, perception of risk, facts to consider about human psychology in a crisis, and how to communicate effectively in a crisis. The Crisis Communication Plan-Developing an emergency/crisis communication plan, Information verification and clearance/approval procedures, agreements on information release authorities (who releases what/when/how, procedures to secure needed resources (space, equipment, people) to operate the public information. The nine steps of crisis response. Surviving the first 48 hours of an emergency: Be first, be right, be credible. The Role of the Spokesperson- The role of the spokesperson in an emergency, what makes a good spokesperson, general recommendations for spokespersons in all settings, pitfalls for spokespersons during an emergency, when emotions and accusations run high in an emergency public meeting, what spokespersons should know when talking through the media, general media interview pitfalls, media opportunity or press conference tips, counters to electronic media interview techniques, radio interview tips, television interview tips, what to wear on television, assessing your communication skills and habits, facial expressions, voice cues, body positions and movements, and effective nonverbal communication. Working With the Media- Think local media first, what do reporters want, getting emergency information to the media, the press conference or media opportunity, telephone news conferences/Web casts, commercial press release services, E-mail listservs and broadcast faxes, Web sites/video streaming, and responding to media calls. Writing For the Media During a Crisis- What your media release should include, press statements are not press releases, media factsheets/backgrounders, visuals, video press releases, and B-roll. Press Conferences- Where to hold the press conference, whom to invite, how and when to invite the media, how to conduct the media opportunity, using visuals and handouts.

Flu

Flu PDF Author: Gina Kolata
Publisher: Farrar, Straus and Giroux
ISBN: 1429979356
Category : Social Science
Languages : en
Pages : 378

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Book Description
Veteran journalist Gina Kolata's Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It presents a fascinating look at true story of the world's deadliest disease. In 1918, the Great Flu Epidemic felled the young and healthy virtually overnight. An estimated forty million people died as the epidemic raged. Children were left orphaned and families were devastated. As many American soldiers were killed by the 1918 flu as were killed in battle during World War I. And no area of the globe was safe. Eskimos living in remote outposts in the frozen tundra were sickened and killed by the flu in such numbers that entire villages were wiped out. Scientists have recently rediscovered shards of the flu virus frozen in Alaska and preserved in scraps of tissue in a government warehouse. Gina Kolata, an acclaimed reporter for The New York Times, unravels the mystery of this lethal virus with the high drama of a great adventure story. Delving into the history of the flu and previous epidemics, detailing the science and the latest understanding of this mortal disease, Kolata addresses the prospects for a great epidemic recurring, and, most important, what can be done to prevent it.

Global Health and the Future Role of the United States

Global Health and the Future Role of the United States PDF Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309457637
Category : Medical
Languages : en
Pages : 385

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Book Description
While much progress has been made on achieving the Millenium Development Goals over the last decade, the number and complexity of global health challenges has persisted. Growing forces for globalization have increased the interconnectedness of the world and our interdependency on other countries, economies, and cultures. Monumental growth in international travel and trade have brought improved access to goods and services for many, but also carry ongoing and ever-present threats of zoonotic spillover and infectious disease outbreaks that threaten all. Global Health and the Future Role of the United States identifies global health priorities in light of current and emerging world threats. This report assesses the current global health landscape and how challenges, actions, and players have evolved over the last decade across a wide range of issues, and provides recommendations on how to increase responsiveness, coordination, and efficiency â€" both within the U.S. government and across the global health field.