Author: Alexei Vazquez
Publisher: Academic Press
ISBN: 0128123354
Category : Science
Languages : en
Pages : 86
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Book Description
Overflow Metabolism: From Yeast to Marathon Runners provides an overview of overflow metabolism, reviewing the major phenomenological aspects as observed in different organisms, followed by a critical analysis of proposed theories to explain overflow metabolism. In our ideal view of metabolism, we think of catabolism and anabolism. In catabolism nutrients break down to carbon dioxide and water to generate biochemical energy. In anabolism nutrients break down to generate building blocks for cell biosynthesis. Yet, when cells are pushed to high metabolic rates they exhibit incomplete catabolism of nutrients, with a lower energy yield and excretion of metabolic byproducts. This phenomenon, characterized by the excretion of metabolic byproducts that could otherwise be used for catabolism or anabolism, is generally known as overflow metabolism. Overflow metabolism is a ubiquitous phenotype that has been conserved during evolution. Examples are the acetate switch in the bacterium E. coli, Crabtree effect in unicellular eukaryote yeasts, the lactate switch in sports medicine, and the Warburg effect in cancer. Several theories have been proposed to explain this seemingly wasteful phenotype. Yet, there is no consensus about what determines overflow metabolism and whether it offers any selective advantage. - Includes examples of overflow metabolism and major phenomenological features - Features a critical view of proposed theories to explain overflow metabolism - Provides a summary of our preview work, proposing molecular crowding as the cause of overflow metabolism, together with new unpublished results
Author: Abdelhamid Ajbar
Publisher: CRC Press
ISBN: 1439867143
Category : Mathematics
Languages : en
Pages : 370
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Book Description
A ubiquitous tool in mathematical biology and chemical engineering, the chemostat often produces instabilities that pose safety hazards and adversely affect the optimization of bioreactive systems. Singularity theory and bifurcation diagrams together offer a useful framework for addressing these issues. Based on the authors’ extensive work in this field, Dynamics of the Chemostat: A Bifurcation Theory Approach explores the use of bifurcation theory to analyze the static and dynamic behavior of the chemostat. Introduction The authors first survey the major work that has been carried out on the stability of continuous bioreactors. They next present the modeling approaches used for bioreactive systems, the different kinetic expressions for growth rates, and tools, such as multiplicity, bifurcation, and singularity theory, for analyzing nonlinear systems. Application The text moves on to the static and dynamic behavior of the basic unstructured model of the chemostat for constant and variable yield coefficients as well as in the presence of wall attachment. It then covers the dynamics of interacting species, including pure and simple microbial competition, biodegradation of mixed substrates, dynamics of plasmid-bearing and plasmid-free recombinant cultures, and dynamics of predator–prey interactions. The authors also examine dynamics of the chemostat with product formation for various growth models, provide examples of bifurcation theory for studying the operability and dynamics of continuous bioreactor models, and apply elementary concepts of bifurcation theory to analyze the dynamics of a periodically forced bioreactor. Using singularity theory and bifurcation techniques, this book presents a cohesive mathematical framework for analyzing and modeling the macro- and microscopic interactions occurring in chemostats. The text includes models that describe the intracellular and operating elements of the bioreactive system. It also explains the mathematical theory behind the models.
Author: Kazuyuki Shimizu
Publisher: CRC Press
ISBN: 1351650106
Category : Science
Languages : en
Pages : 377
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Book Description
The global warming problem is becoming critical year by year, causing climate disaster all over the world, where it has been believed that the CO2 gas emitted from the factories and the burning of fossil fuels may be one of the reasons of global warming. Moreover, the global stock of fossil fuels is limited, and may run out soon within several tens of years. Although wind, geo-thermal, and tide energies have been considered as clean energy sources, those depend on the land or sea locations and subject to the climate change. Biofuel and biochemical production from renewable bio-resources has thus been paid recent attention from environmental protection and energy production points of view, where the current chemical and energy producing plants can be also utilized with slight modification. The so-called 1st generation biofuels have been produced from corn starch and sugarcane in particular in USA and Brazil. However, this causes the problem of the so-called "food and energy issues" as the production scale increases. The 2nd generation biofuel production from lingo-cellulosic biomass or wastes has thus been paid recent attention. However, it requires energy intensive pretreatment for the degradation of lingo-cellulosic biomass, and the fermentation is slow due to low growth rate, and thus the productivity of biofuels and bio-chemicals is low. The 3rd generation biofuel production from photosynthetic organisms such as cyanobacteria and algae has been also paid attention, because such organisms can grow with only sun light and CO2 in the air, but the cell growth rate and thus the productivity of the fuels is significantly low. The main part or core of such production processes is the fermentation by micro-organisms. In particular, it is critical to properly understand the cell metabolism followed by the efficient metabolic engineering. The book gives comprehensive explanation of the cell metabolism and the metabolic regulation mechanisms of a variety of micro-organisms. Then the efficient metabolic engineering approaches are explained to properly design the microbial cell factories for the efficient cell growth and biofuel and biochemical production.
Author: Christina Smolke
Publisher: CRC Press
ISBN: 142007766X
Category : Medical
Languages : en
Pages : 570
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Book Description
This second volume of the Metabolic Pathway Engineering Handbook delves into evolutionary tools and gene expression tools for metabolic pathway engineering. It covers applications of emerging technologies including recent research genome-wide technologies, DNA and phenotypic microarrays, and proteomics tools for experimentally determining flux thro
Author: Anton A. Kiss
Publisher: Elsevier
ISBN: 0128186356
Category : Technology & Engineering
Languages : en
Pages : 1886
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Book Description
The 29th European Symposium on Computer Aided Process Engineering, contains the papers presented at the 29th European Symposium of Computer Aided Process Engineering (ESCAPE) event held in Eindhoven, The Netherlands, from June 16-19, 2019. It is a valuable resource for chemical engineers, chemical process engineers, researchers in industry and academia, students, and consultants for chemical industries. - Presents findings and discussions from the 29th European Symposium of Computer Aided Process Engineering (ESCAPE) event
Author: Steven A. Frank
Publisher: Princeton University Press
ISBN: 0691231192
Category : Science
Languages : en
Pages : 400
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Book Description
A powerful framework for understanding how natural selection shapes adaptation and biological design Design and diversity are the two great challenges in the study of life. Microbial Life History draws on the latest advances in microbiology to describe the fundamental forces of biological design and apply these evolutionary processes to a broad diversity of traits in microbial metabolism and biochemistry. Emphasizing how to formulate and test hypotheses of adaptation, Steven Frank provides a new foundation for exploring the evolutionary forces of design. He discusses the economic principles of marginal valuations, trade-offs, and payoffs in risky and random environments; the social aspects of conflict and cooperation; the demographic aspects of age and spatial heterogeneity; and the engineering control theory principles by which systems adjust to environments. Frank then applies these evolutionary principles to the biochemistry of microbial metabolism, providing the first comprehensive link between the forces that shape biological design and cellular energetics. Tracing how natural selection sculpts metabolism, Microbial Life History provides new perspectives on the life histories of organisms, from growth rate and survival to dispersal and defense against attack. Along the way, this incisive book addresses the conceptual and philosophical challenges confronting evolutionary biologists and other practitioners who study biological design and seek to apply its lessons.
Author: Christina Smolke
Publisher: CRC Press
ISBN: 1420005626
Category : Medical
Languages : en
Pages : 1247
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Book Description
Christina Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer's yeast, is regarded as one of the most brilliant minds in biomedical engineering. In this handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in metab
Author: Colin Ratledge
Publisher: Cambridge University Press
ISBN: 9780521779173
Category : Medical
Languages : en
Pages : 588
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Book Description
Biotechnology impinges on everyone's lives. It is one of the major technologies of the twenty-first century. Its huge, wide-ranging, multi-disciplinary activities include recombinant DNA techniques, cloning and genetics, and the application of microbiology to the production of goods as every-day as bread, beer, cheese and antibiotics. It continues to revolutionise treatments of many diseases, and is used to provide clean technologies and to deal with environmental problems. Basic Biotechnology is a mainstream account of the current state of biotechnology, written to provide the reader with insight, inspiration and instruction into the skills and arts of the subject. It does this by explaining the fundamental aspects that underpin all biotechnology and provides examples of how these principles are put into operation: from starting substrate to final product. The book is essential reading for all students and teachers of biotechnology and applied microbiology and for researchers in the many biotechnology industries.
Author: Elizabeth A. Bernays
Publisher: CRC Press
ISBN: 100069447X
Category : Science
Languages : en
Pages : 171
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Book Description
First Published in 1989, this book explores the relationship between plants and insects and the ways in which they interact with each other. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of oncology, and other practitioners in their respective fields.
Author: Kalidas Shetty
Publisher: CRC Press
ISBN: 1420007726
Category : Technology & Engineering
Languages : en
Pages : 672
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Book Description
Functional Foods and Biotechnology focuses the information from the recently published Food Biotechnology to illuminate the role of biochemical processing in the improvement of functional foods and the increase of nutrient value. Applying scientific concepts, the text explores the design of functional food ingredients, the bio-mobilization of major nutrients, and the use of specific phenolic metabolites in disease prevention. Specialty topics include oxidation and disease, antibodies from eggs, phytochemicals as antimicrobials, and passive immune improvement with pro- and pre-biotics. The text provides key emerging techniques for improving food production and processing, enhancing food safety and quality, and increasing nutritional values a
