Overcoming Limitations of Iontronic Delivery Devices

Overcoming Limitations of Iontronic Delivery Devices PDF Author: Maria Seitanidou
Publisher: Linköping University Electronic Press
ISBN: 9179298931
Category :
Languages : en
Pages : 76

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Book Description
Organic electronic devices are considered as one of the best candidates to replace conventional inorganic electronic devices due to their electronic conductive functionality, low-cost production techniques, the ability to tune their optical and electronic properties using organic chemistry, and their mechanical flexibility. Moreover, these systems are ideal for bioelectronic applications due to their softness, biocompatibility, and most importantly, their electronic and ionic transport. Indeed, these materials are compatible with biological tissues and cells improving the signal transduction between electronic devices and electrically excitable cells. As ions serve as one of the primary signal carriers of cells, they can selectively tune a cell’s activity; therefore, an improved interface between electronics and biological systems can offer several advantages in healthcare, e.g. the development of efficient drug delivery devices. The main focus of this thesis is the development of electronic delivery devices. Electrophoretic delivery devices called organic electronic ion pumps (OEIPs) are used to electronically control the delivery of small ions, neurotransmitters, and drugs with high spatiotemporal resolution. This work elucidates the ion transport processes and phenomena that happen in the ion exchange membranes during ion delivery and clarifies which parameters are crucial for the ion transport efficiency of the OEIPs. This thesis shows a systematic investigation of these parameters and indicates new methods and OEIP designs to overcome these challenges. Two novel OEIP designs are developed and introduced in this thesis to improve the local ion transport while limiting side effects. OEIPs based on palladium proton trap contacts can improve the membrane permselectivity and optimize the delivery of γ-aminobutyric acid (GABA) neurotransmitters at low pH while preventing any undesired pH changes from proton transport in the biological systems. And OEIPs based on glass capillary fibers are developed to overcome the limitations of devices on planar substrates, related to more complex and larger biologically relevant ion delivery with low mobility for implantable applications. This design can optimize the transport of ions and drugs such as salicylic acid (SA) at low concentrations and at relatively much higher rates, thereby addressing a wider range of biomedically relevant applications and needs.

Overcoming Limitations of Iontronic Delivery Devices

Overcoming Limitations of Iontronic Delivery Devices PDF Author: Maria Seitanidou
Publisher: Linköping University Electronic Press
ISBN: 9179298931
Category :
Languages : en
Pages : 76

Get Book Here

Book Description
Organic electronic devices are considered as one of the best candidates to replace conventional inorganic electronic devices due to their electronic conductive functionality, low-cost production techniques, the ability to tune their optical and electronic properties using organic chemistry, and their mechanical flexibility. Moreover, these systems are ideal for bioelectronic applications due to their softness, biocompatibility, and most importantly, their electronic and ionic transport. Indeed, these materials are compatible with biological tissues and cells improving the signal transduction between electronic devices and electrically excitable cells. As ions serve as one of the primary signal carriers of cells, they can selectively tune a cell’s activity; therefore, an improved interface between electronics and biological systems can offer several advantages in healthcare, e.g. the development of efficient drug delivery devices. The main focus of this thesis is the development of electronic delivery devices. Electrophoretic delivery devices called organic electronic ion pumps (OEIPs) are used to electronically control the delivery of small ions, neurotransmitters, and drugs with high spatiotemporal resolution. This work elucidates the ion transport processes and phenomena that happen in the ion exchange membranes during ion delivery and clarifies which parameters are crucial for the ion transport efficiency of the OEIPs. This thesis shows a systematic investigation of these parameters and indicates new methods and OEIP designs to overcome these challenges. Two novel OEIP designs are developed and introduced in this thesis to improve the local ion transport while limiting side effects. OEIPs based on palladium proton trap contacts can improve the membrane permselectivity and optimize the delivery of γ-aminobutyric acid (GABA) neurotransmitters at low pH while preventing any undesired pH changes from proton transport in the biological systems. And OEIPs based on glass capillary fibers are developed to overcome the limitations of devices on planar substrates, related to more complex and larger biologically relevant ion delivery with low mobility for implantable applications. This design can optimize the transport of ions and drugs such as salicylic acid (SA) at low concentrations and at relatively much higher rates, thereby addressing a wider range of biomedically relevant applications and needs.

How to Overcome Limitations in Life

How to Overcome Limitations in Life PDF Author: Bishop Ben Ugbine
Publisher:
ISBN: 9781090709288
Category : Religion
Languages : en
Pages : 224

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Book Description
The spirit of limitations and stagnation has really stopped many from achieving their dreams and goals in life. Life's full glory and potentials are not fully realized when one's life is restricted and limited. Indeed, many in life have been caged by the forces of darkness so much so that people have been left frustrated and dejected. We need to understand that God has endowed us with every blessing we are supposed to have but the forces of darkness have stolen these blessings from us. If only we can see all the blessings that God has given us and where we appear to be now, it will cause us to rise-up with holy anger to pray the kind of prayers that would change our world. There is no need going through life allowing the forces of darkness limiting our lives. We need to wake up and reclaim everything the devil has stolen from us and live our lives to the fullest. We must not allow the devil and his forces to continue to limit our lives and make us failures and frustrated people. It is very necessary for us to understand who we are in God and take our position as children of the Most High God, and begin to live our lives to the full. This book is designed to stir you up and cause you to develop holy anger and reclaim your full blessings from the enemy. Lack of knowledge keeps people in perpetual bondage and once we are knowledgeable about the deceptions and the wiles of the devil, we will recover everything he's stolen from us. No matter what limitation we are currently facing in our lives, we can turn things around and create a great change in our lives. We must understand that the limitations we tend to experience in our lives stems from the devil taking control over our minds. The mind is the battle ground of the demonic forces and they tend to limit one's life through evil and negative suggestions. When these suggestions have gained ground in our lives, it begins to limit what we can do and achieve. There are generational limiting powers that have bound our lives through wrong family foundation. Truly this has caused many people's lives to be full of struggles and frustration, and when one's life is frustrated, one becomes stagnate and unproductive. We need to take charge over our lives and fight to break this spirit of limitations and rise and be what God wants us to be. Every blessing and inheritance we have in God must be fully appropriated and enjoyed. There is nothing that can stop us in life if we make up our minds to succeed. And success begins with a change of our mind-set and with the anointing power of God over us, these limiting forces in our lives will be fully broken. My prayer for you is that by the time you are done reading this book, every chain of limitation and stagnation, will drop from you and your life will have full meaning and all your dreams and goals will be fully realized. The spirit of limitations and stagnation has really stopped many from achieving their dreams and goals in life. Life's full glory and potentials are not fully realized when one's life is restricted and limited. Indeed, many in life have been caged by the forces of darkness so much so that people have been left frustrated and dejected. We need to understand that God has endowed us with every blessing we are supposed to have but the forces of darkness have stolen these blessings from us. If only we can see all the blessings that God has given us and where we appear to be now, it will cause us to rise-up with holy anger to pray the kind of prayers that would change our world.

Live Life FREE!

Live Life FREE! PDF Author: Renee Branson
Publisher:
ISBN: 9781881465072
Category :
Languages : en
Pages :

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Book Description
Everyone faces limitations and challenges to living a life of true freedom, but you can Live Life FREE in every area of your life! You may be facing challenges in life that make you feel confined, controlled or even owned by unseen forces such as fear, debt, strongholds, pleasure, love of money, possessions, greed, your profession - even your ministry! What starts out in life as a simple attraction, may lead to habitual, limiting behaviors that can even become enslaving.Limitations begin to occur when you place things that bring pleasure or delight above your desire for your Creator. God made you to be fulfilled through close relationship and fellowship with Him. You know you face limitations when you are never truly satisfied, but instead experience an insatiable, constant desire for more of the things you crave. You know you are seriously limited when an unknown compelling or driving force takes over and begins to control your thoughts, motives, actions, finances, and relationships. Only God can truly set you free to be all He has created you to be.¿This book will minister to your deepest needs and instruct you how to fight the good fight of faith to overcome your limitations.¿Inside these pages are five basic steps designed to bring complete freedom and restoration to every area of your life - spiritually, mentally, emotionally, physically and relationally.¿This revelation is about God's truth, love, and grace that is extended to you through the blood of the Lord Jesus Christ in His death, burial and resurrection.As you read this book, allow the Holy Spirit to shift and change you from glory to glory, into the image of the God who created you to Live Life FREE!

Overcoming Obstacles: Become Overcomers

Overcoming Obstacles: Become Overcomers PDF Author: Bill Vincent
Publisher: Lulu.com
ISBN: 0359302157
Category : Religion
Languages : en
Pages : 124

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Book Description
This book is to help saints get through trials. We all have hard times that seem to go on and on. The anointed Word of God will help those who believe to grow instead of fall. Many Christians have given up at the brink of a miracle. One thing to understand is God has called us to be overcomers. In this we are going to reveal some obstacles that Satan wants to destroy the Saints with. We do not have to go from defeat to defeat but victory to victory.

Overcoming Obstacles and Finding Success

Overcoming Obstacles and Finding Success PDF Author: Kevin R. Harris
Publisher: Taylor & Francis
ISBN: 1040217389
Category : Psychology
Languages : en
Pages : 191

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Book Description
This valuable book identifies common obstacles in any endeavor that can impact on success and offers highly accessible exercises to help readers overcome them. Featuring expertise from dozens of high-level performers regarding their journey to the top of their domain, it offers practical advice on how to separate yourself from your competition and stand out from the crowd. All performers, whether beginners or world class, in sports, business, the arts, and beyond, have encountered obstacles in their careers. Acknowledging that every successful person must work hard, this book offers a blueprint for those wanting to map out their own success based on over twenty years of research into performance, and the authors’ experiences of guiding career development among their mentees and teaching courses on the topic. Each chapter includes a case study that exemplifies one of the most common obstacles individuals face in their efforts to be successful, including topics like impostor syndrome, artificial ceilings, facing rejection, and not allowing for rest or recovery. Following this, the chapter goes on to provide a series of engaging exercises for readers to reflect on their own performance and techniques, and enables them to strategize ways they can modify their performance to achieve better results. Throughout, the book is underpinned by theoretical frameworks from performance psychology, clear actionable steps for achieving success, and suggested readings for further study. Written with career development in mind, the applications of this book are far-reaching, with relevance for all those looking to excel in their chosen fields.

Overcoming Obstacles in CBT

Overcoming Obstacles in CBT PDF Author: Craig Chigwedere
Publisher: SAGE
ISBN: 1446292592
Category : Psychology
Languages : en
Pages : 250

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Book Description
While many textbooks explain the techniques of CBT, few fully explore the issues surrounding their application in real-life practice. This unique book comes to the rescue of anyone struggling with the challenges of practising CBT, whether you are a trainee working under supervision or a qualified practitioner. It examines key obstacles, issues and difficulties encountered over the course of the therapy, illustrated with extensive case examples. Learning objectives, practice exercises and further reading lists help you engage with and relate the issues to your own practice. Acknowledging that people are more complex than just the presenting disorder, the authors consider questions around: o Good practice in assessment and case formulation o The challenge of diagnosis o Key client issues, such as guilt and shame, perfectionism, and inability to tolerate storing feeling o The therapeutic relationship o Organisational factors. This succinct and accessible guide throws a lifebelt to any CBT trainee or therapist struggling under the realities of today′s psychotherapy and counselling practice, particularly within NHS settings.

Overcoming Obstacles to Fulfillment of Divine Destiny

Overcoming Obstacles to Fulfillment of Divine Destiny PDF Author: Stephen U. Aja
Publisher: Xulon Press
ISBN: 1594674906
Category : Religion
Languages : en
Pages : 182

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Book Description


Overcoming Obstacles

Overcoming Obstacles PDF Author: Jibby Peter Dcruz
Publisher: OrangeBooks Publication
ISBN:
Category : Self-Help
Languages : en
Pages : 140

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Book Description
When was the last time people actually stopped to think about what's keeping them afraid? What surprises awaits if a person actually sticks onto a passing thought? Just realize that it is on the other side of fear that greatness awaits them. This book is for anyone who wants to get to the greatest version of themselves. Get first-hand experience on the author’s journey that stretches the limits of the human body and all the mental mountains that had to be climbed in between.

Overcoming Obstacles

Overcoming Obstacles PDF Author: Stan Barren
Publisher: InspirationDB
ISBN:
Category : Self-Help
Languages : en
Pages : 113

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Book Description
In a world rife with challenges, how did some individuals rise above their obstacles while others succumb to them? Dive deep into the minds, hearts, and souls of the world's most resilient figures and discover secrets to developing an unyielding spirit. "Overcoming Obstacles" isn't just a historical account; it's a toolkit designed for YOU. Whether you're facing personal struggles, professional setbacks, or emotional challenges, this book provides actionable strategies adopted by high achievers throughout history and in our modern era. What's Inside? Powerful Narratives: Journey through time with stories of historical figures like Nelson Mandela and Mahatma Gandhi, and learn from modern icons like Oprah Winfrey and Elon Musk. The Psychology of Resilience: Delve into the science and mindset behind bouncing back from adversity. Actionable Techniques: From mental conditioning to leveraging technology, equip yourself with tools and exercises proven to fortify resilience. Community and Connection: Understand the profound impact of a support system, and discover ways to cultivate your own. Join thousands of readers in understanding the essence of resilience. Let "Overcoming Obstacles" guide you in transforming life's challenges into stepping stones toward a brighter, more fulfilled future.

Overcoming Obstacles to Peace

Overcoming Obstacles to Peace PDF Author: James Dobbins
Publisher: Rand Corporation
ISBN: 0833078631
Category : History
Languages : en
Pages : 349

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Book Description
"This volume analyzes the impediments that local conditions pose to successful outcomes of nation-building interventions in conflict-affected areas. Previous RAND studies of nation-building focused on external interveners' activities. This volume shifts the focus to internal circumstances, first identifying the conditions that gave rise to conflicts or threatened to perpetuate them, and then determining how external and local actors were able to modify or work around them to promote enduring peace. It examines in depth six varied societies: Cambodia, El Salvador, Bosnia and Herzegovina, East Timor, Sierra Leone, and the Democratic Republic of the Congo. It then analyzes a larger set of 20 major post-Cold War nation-building interventions. The authors assess the risk of renewed conflict at the onset of the interventions and subsequent progress along five dimensions: security, democratization, government effectiveness, economic growth, and human development. They find that transformation of many of the specific conditions that gave rise to or fueled conflict often is not feasible in the time frame of nation-building operations but that such transformation has not proven essential to achieving the primary goal of nation-building -- establishing peace. Most interventions in the past 25 years have led to enduring peace, as well as some degree of improvement in the other dimensions assessed. The findings suggest the importance of setting realistic expectations -- neither expecting nation-building operations to quickly lift countries out of poverty and create liberal democracies, nor being swayed by a negative stereotype of nation-building that does not recognize its signal achievements in the great majority of cases."--Page 4 of cover.