Oral & Intravenous Bisphosphonate-induced Osteonecrosis of the Jaws PDF Download
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Author: Robert E. Marx
Publisher: Quintessence Publishing (IL)
ISBN:
Category : Medical
Languages : en
Pages : 172
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Book Description
Oral and Intravenous Bisphosphonate-Induced Osteonecrosis of the Jaws deals with dentistry.
Author: Robert E. Marx
Publisher: Quintessence Publishing (IL)
ISBN:
Category : Medical
Languages : en
Pages : 172
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Book Description
Oral and Intravenous Bisphosphonate-Induced Osteonecrosis of the Jaws deals with dentistry.
Author: Robert E. Marx
Publisher:
ISBN: 9780867159011
Category :
Languages : en
Pages : 164
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Book Description
Author: Sven Otto
Publisher: Springer
ISBN: 3662437333
Category : Medical
Languages : en
Pages : 216
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Book Description
Osteonecrosis of the jaws is a well-known side-effect of antiresorptive therapy that predominantly occurs in patients suffering from malignant diseases and receiving intravenous administrations of nitrogen-containing bisphosphonates or subcutaneous administrations of denosumab, a monoclonal antibody. Less frequently it may also be observed in patients with osteoporosis who are being treated with these antiresorptive drugs This textbook provides detailed, up-to-date information on all aspects of medication-related osteonecrosis of the jaws, including clinical features, pathogenesis, treatment options, and preventive measures. It also explains safe prevention and treatment strategies for patients receiving antiresorptive drugs who require extractions, implant insertions, and other dento-alveolar surgeries. This book will be of major interest for medical and dental students, dentists, and oral and maxillofacial surgeons as well as osteologists and oncologists.
Author: Francesco Saverio De Ponte
Publisher: Springer Science & Business Media
ISBN: 8847020832
Category : Medical
Languages : en
Pages : 186
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Book Description
During the early 19th century, it was discovered that adding yellow (now called white) phosphorous to matchstick heads made it easier to ignite matches. The phosphorous vapors were breathed in by workers and combined with other chemicals in the body to produce a potent nitrogen-containing bisphosphonate. Today's oral nitrogen-containing bisphosphonates and intravenous nitrogen-containing bisphosphonates circulate around the body the same way as the phosphorous vapors, and are absorbed into bone and ingested by osteoclasts. When this unique binding process of bisphosphonates to bone occurs, osteoclasts are poisoned, and this reduces or eliminates bone turnover. Alveolar bone in the mandible and maxilla turns over more rapidly than in long bones, so the jaws are a better target for bisphosphonate toxicity. It wasn't until 2003 that today's intravenous and oral nitrogen-containing bisphosphonate medications were implicated as major risk factors in the development of exposed necrotic bone of the jaws. Most of the researchers who reported cases of bisphosphonate-induced osteonecrosis of the jaw found that these patients were treated with zoledronate, pamidronate, or a combination of these drugs, which are commonly used for treating breast cancer or myeloma. In about 5% of cases, subjects with BIONJ were being treated for osteoporosis. Precipitating events that contribute to BIONJ are tooth extractions (about 50% of cases), mandibular exostoses, periodontal disease, and local trauma from ill-fitting dentures. It is not known if the placement of dental implants is a precipitating factor. The book aims to meet the need of medical practitioners working in all fields that use bisphosphonates, and to present the conservative and surgical treatment methods currently in use. There will also be detailed information on the literature relating to dental implants in patients treated with bisphosphonates.
Author: John P. Bilezikian
Publisher: Wiley-Blackwell
ISBN:
Category : Medical
Languages : en
Pages : 100
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Book Description
"This volume presents manuscripts stemming from the conference entitled 'Bisphosphonates & Osteonecrosis of the Jaw,' held May 19, 2007 at the New York Academy of Sciences
Author: Salvatore L. Ruggiero
Publisher: Elsevier Health Sciences
ISBN: 0323413471
Category : Medical
Languages : en
Pages : 113
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Book Description
Editor Salvatore Ruggiero, DMD, MD and authors review the Diagnosis, Management and Prevention of Medication-related Osteonecrosis of the Jaw. Articles will include: Osteoporosis and bone modulation therapies: indications and outcomes; Antiresorptive therapies for the treatment of malignant osteolytic bone disease; Clinical presentation and staging of antiresorptive agent-induced osteonecrosis of the jaw; Epidemiology and risk factors of antiresorptive agent-induced osteonecrosis of the jaw; Basic science research of antiresorptive agent-induced osteonecrosis of the jaw: an update; Pathophysiology of antiresorptive agent-induced osteonecrosis of the jaw: what we know and what we don’t know; The genetics of osteonecrosis of the jaw; Preventive strategies for patients at risk of antiresorptive agent-induced osteonecrosis of the jaw; Non-operative and operative therapies for treatment of antiresorptive agent-induced osteonecrosis of the jaw; The role of anti-angiogenic therapy in the development of osteonecrosis of the jaw; Antiresorptive therapies: what they are and how do they work, and more!
Author: Kenneth Fleisher
Publisher: Thieme
ISBN: 313258228X
Category : Medical
Languages : en
Pages : 125
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Book Description
A collaboration between some of the leading international experts in the field, AOCMF proudly presents Antiresorptive Drug-related Osteonecrosis of the Jaw (ARONJ)-a Guide to Research, which unravels the many biologic processes and risk factors associated with this debilitating condition. With its unknown pathophysiology, lack of established management regimens, and because of the millions of patients currently taking antiresorptive agents, this important book on ARONJ has been produced to provide the latest in contemporary evidence and insight. The book's key features include: Detailed analysis of the historical definitions, classifications, and clinical features of ARONJ Review of the risk factors and treatment options currently available, and why the jaw bone is predominantly affected Discussion on the use of large and small animals in modelling. With dozens of clinical images to help illustrate the impact of this condition on real patients, Antiresorptive Drug-related Osteonecrosis of the Jaw (ARONJ)-a Guide to Research is an excellent resource for anyone involved or interested in this important medical field.
Author: Zaher Jabbour
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
"Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is an oral complication found in patients receiving high doses of intravenous bisphosphonates for treatment of cancer or osteoporosis. BRONJ is clinically defined as an area of exposed bone in the maxillofacial region that has persisted for more than 8 weeks in patients undergoing, or with previous bisphosphonate treatment and no history of radiation therapy to the jaws. Many hypotheses have been formulated to explain BRONJ based on a bacterial etiology or the direct effects of bisphosphonates on the jaw bone, soft tissue, or vascularization. Challenges in the management of BRONJ arise since the pathophysiology remains poorly defined. The American Association of Oral and Maxillofacial Surgeons recommend a conservative approach of treatment for BRONJ in its early stages, and surgical intervention for the more advanced disease. An interruption of bisphosphonates therapy also is suggested, depending on the patient's overall condition. To determine the efficacy of different treatment interventions, we conducted a retrospective chart review of patients with BRONJ treated at the Montreal General Hospital. The study revealed that both conservative and surgical treatments were used for patients with BRONJ stage II, but that surgical treatment resulted in a faster resolution of the condition. Based on our chart review, we found that corticosteroids were frequently prescribed to BRONJ patients. Therefore, BRONJ-like disease was induced in rats by administering the bisphosphonate zoledronic acid and the corticosteroid dexamethasone. This pre-clinical model showed that bisphosphonate withdrawal might benefit the outcome by allowing bone remodeling to resume. In addition, this model showed that the combined administration of bisphosphonate and corticosteroid increased the suppression of bone turnover compared to the administration of either drug alone. To further explore the hypothesis that bacterial infection contributes to the development of BRONJ, we used the DNA checkerboard technique to determine whether bacterial probes prepared from human oral bacteria hybridized with the whole genome DNA extracted from the oral cavity of rats. This technique was then used to detect and quantify 43 microbial species relevant to human oral health in samples taken from the oral cavity of patients with BRONJ and rats with BRONJ-like disease. The results suggested that the microbiota of exposed bone in BRONJ patients had a different profile compared to the bacterial profile of other hard and soft tissues of the mouth. This unique microbial profile could have been caused by the medications the patients were taking, including chemotherapy and bisphosphonate. E. corrodens, S. gordonii, and S. constellatus were the three most dominant bacterial species in the exposed bone in addition to other non-pathogenic microbial species, and species linked to periodontal diseases and bone infection. As in the BRONJ patients, the exposed bone in rats treated with bisphosphonate and corticosteroid was colonized mainly by non-pathogenic bacteria. The most abundant species in the site of exposed bone in rats were S. pasteuri, S. parasanguinis, and S. mitis. " --
Author: Krishnamurthy Bonanthaya
Publisher: Springer Nature
ISBN: 9811513465
Category : Face
Languages : en
Pages : 1965
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Book Description
This is an open access book with CC BY 4.0 license. This comprehensive open access textbook provides a comprehensive coverage of principles and practice of oral and maxillofacial surgery. With a range of topics starting from routine dentoalveolar surgery to advanced and complex surgical procedures, this volume is a meaningful combination of text and illustrations including clinical photos, radiographs, and videos. It provides guidance on evidence-based practices in context to existing protocols, guidelines and recommendations to help readers deal with most clinical scenarios in their daily surgical work. This multidisciplinary textbook is meant for postgraduate trainees, young practicing oral surgeons and experienced clinicians, as well as those preparing for university and board certification exams. It also aids in decision-making, the implementation of treatment plans and the management of complications that may arise. This book is an initiative of Association of Oral and Maxillofacial Surgeons of India (AOMSI) to its commitment to academic medicine. As part of this commitment, this textbook is in open access to help ensure widest possible dissemination to readers across the world. ; Open access Unique presentation with contents divided into color-coded core competency gradations Covers all aspects of oral and maxillofacial surgery Supplemented with videos of all commonly carried out procedures as operative video Every chapter or topic concludes with "future perspective" and addresses cutting edge advances in each area Every topic has a pull out box that provides the most relevant systematic reviews/ key articles to every topic.
Author: Marc Baltensperger
Publisher: Springer Science & Business Media
ISBN: 3540287663
Category : Medical
Languages : en
Pages : 320
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Book Description
“Osteomyelitis of the Jaws” is the first textbook of its kind covering exclusively all aspects of this challenging disease. A clear classification of osteomyelitis of the jaws is provided. Clinical presentation and diagnosis are meticulously described and illustrated. Radiological imaging from conventional radiographs to CT, MRI and PET diagnosis are outlined for all types of osteomyelitis of the jaws. Pathology and Pathophysiology of this disease are described in a clear way. All therapeutic modalities from surgery to antibiotic and hyperbaric oxygen therapy are comprehensively outlined and discussed. Each type of Osteomyelitis of the jaws are additionally described and illustrated in case reports giving this book a very practical approach to the subject.
