Optimal Covariate Designs

Optimal Covariate Designs PDF Author: Premadhis Das
Publisher: Springer
ISBN: 8132224612
Category : Computers
Languages : en
Pages : 231

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Book Description
This book primarily addresses the optimality aspects of covariate designs. A covariate model is a combination of ANOVA and regression models. Optimal estimation of the parameters of the model using a suitable choice of designs is of great importance; as such choices allow experimenters to extract maximum information for the unknown model parameters. The main emphasis of this monograph is to start with an assumed covariate model in combination with some standard ANOVA set-ups such as CRD, RBD, BIBD, GDD, BTIBD, BPEBD, cross-over, multi-factor, split-plot and strip-plot designs, treatment control designs, etc. and discuss the nature and availability of optimal covariate designs. In some situations, optimal estimations of both ANOVA and the regression parameters are provided. Global optimality and D-optimality criteria are mainly used in selecting the design. The standard optimality results of both discrete and continuous set-ups have been adapted, and several novel combinatorial techniques have been applied for the construction of optimum designs using Hadamard matrices, the Kronecker product, Rao-Khatri product, mixed orthogonal arrays to name a few.

Optimal Covariate Designs

Optimal Covariate Designs PDF Author: Premadhis Das
Publisher: Springer
ISBN: 8132224612
Category : Computers
Languages : en
Pages : 231

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Book Description
This book primarily addresses the optimality aspects of covariate designs. A covariate model is a combination of ANOVA and regression models. Optimal estimation of the parameters of the model using a suitable choice of designs is of great importance; as such choices allow experimenters to extract maximum information for the unknown model parameters. The main emphasis of this monograph is to start with an assumed covariate model in combination with some standard ANOVA set-ups such as CRD, RBD, BIBD, GDD, BTIBD, BPEBD, cross-over, multi-factor, split-plot and strip-plot designs, treatment control designs, etc. and discuss the nature and availability of optimal covariate designs. In some situations, optimal estimations of both ANOVA and the regression parameters are provided. Global optimality and D-optimality criteria are mainly used in selecting the design. The standard optimality results of both discrete and continuous set-ups have been adapted, and several novel combinatorial techniques have been applied for the construction of optimum designs using Hadamard matrices, the Kronecker product, Rao-Khatri product, mixed orthogonal arrays to name a few.

Topics in Optimal Design

Topics in Optimal Design PDF Author: Erkki P. Liski
Publisher: Springer Science & Business Media
ISBN: 1461300495
Category : Mathematics
Languages : en
Pages : 173

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Book Description
This book covers a wide range of topics in both discrete and continuous optimal designs. The topics discussed include designs for regression models, covariates models, models with trend effects, and models with competition effects. The prerequisites are a basic course in the design and analysis of experiments and some familiarity with the concepts of optimality criteria.

Applied Optimal Designs

Applied Optimal Designs PDF Author: Martijn P.F. Berger
Publisher: John Wiley & Sons
ISBN: 9780470856970
Category : Mathematics
Languages : en
Pages : 320

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Book Description
There is an increasing need to rein in the cost of scientific study without sacrificing accuracy in statistical inference. Optimal design is the judicious allocation of resources to achieve the objectives of studies using minimal cost via careful statistical planning. Researchers and practitioners in various fields of applied science are now beginning to recognize the advantages and potential of optimal experimental design. Applied Optimal Designs is the first book to catalogue the application of optimal design to real problems, documenting its widespread use across disciplines as diverse as drug development, education and ground water modelling. Includes contributions covering: Bayesian design for measuring cerebral blood-flow Optimal designs for biological models Computer adaptive testing Ground water modelling Epidemiological studies and pharmacological models Applied Optimal Designs bridges the gap between theory and practice, drawing together a selection of incisive articles from reputed collaborators. Broad in scope and inter-disciplinary in appeal, this book highlights the variety of opportunities available through the use of optimal design. The wide range of applications presented here should appeal to statisticians working with optimal designs, and to practitioners new to the theory and concepts involved.

A Practical Introduction to Regression Discontinuity Designs

A Practical Introduction to Regression Discontinuity Designs PDF Author: Matias D. Cattaneo
Publisher: Cambridge University Press
ISBN: 1108670423
Category : Political Science
Languages : en
Pages : 118

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Book Description
In this Element and its accompanying second Element, A Practical Introduction to Regression Discontinuity Designs: Extensions, Matias Cattaneo, Nicolás Idrobo, and Rocıìo Titiunik provide an accessible and practical guide for the analysis and interpretation of regression discontinuity (RD) designs that encourages the use of a common set of practices and facilitates the accumulation of RD-based empirical evidence. In this Element, the authors discuss the foundations of the canonical Sharp RD design, which has the following features: (i) the score is continuously distributed and has only one dimension, (ii) there is only one cutoff, and (iii) compliance with the treatment assignment is perfect. In the second Element, the authors discuss practical and conceptual extensions to this basic RD setup.

Optimal Design of Experiments

Optimal Design of Experiments PDF Author: Peter Goos
Publisher: John Wiley & Sons
ISBN: 1119976162
Category : Science
Languages : en
Pages : 249

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Book Description
"This is an engaging and informative book on the modern practice of experimental design. The authors' writing style is entertaining, the consulting dialogs are extremely enjoyable, and the technical material is presented brilliantly but not overwhelmingly. The book is a joy to read. Everyone who practices or teaches DOE should read this book." - Douglas C. Montgomery, Regents Professor, Department of Industrial Engineering, Arizona State University "It's been said: 'Design for the experiment, don't experiment for the design.' This book ably demonstrates this notion by showing how tailor-made, optimal designs can be effectively employed to meet a client's actual needs. It should be required reading for anyone interested in using the design of experiments in industrial settings." —Christopher J. Nachtsheim, Frank A Donaldson Chair in Operations Management, Carlson School of Management, University of Minnesota This book demonstrates the utility of the computer-aided optimal design approach using real industrial examples. These examples address questions such as the following: How can I do screening inexpensively if I have dozens of factors to investigate? What can I do if I have day-to-day variability and I can only perform 3 runs a day? How can I do RSM cost effectively if I have categorical factors? How can I design and analyze experiments when there is a factor that can only be changed a few times over the study? How can I include both ingredients in a mixture and processing factors in the same study? How can I design an experiment if there are many factor combinations that are impossible to run? How can I make sure that a time trend due to warming up of equipment does not affect the conclusions from a study? How can I take into account batch information in when designing experiments involving multiple batches? How can I add runs to a botched experiment to resolve ambiguities? While answering these questions the book also shows how to evaluate and compare designs. This allows researchers to make sensible trade-offs between the cost of experimentation and the amount of information they obtain.

An Introduction to Optimal Designs for Social and Biomedical Research

An Introduction to Optimal Designs for Social and Biomedical Research PDF Author: Martijn P.F. Berger
Publisher: John Wiley & Sons
ISBN: 9780470746929
Category : Mathematics
Languages : en
Pages : 346

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Book Description
The increasing cost of research means that scientists are in more urgent need of optimal design theory to increase the efficiency of parameter estimators and the statistical power of their tests. The objectives of a good design are to provide interpretable and accurate inference at minimal costs. Optimal design theory can help to identify a design with maximum power and maximum information for a statistical model and, at the same time, enable researchers to check on the model assumptions. This Book: Introduces optimal experimental design in an accessible format. Provides guidelines for practitioners to increase the efficiency of their designs, and demonstrates how optimal designs can reduce a study’s costs. Discusses the merits of optimal designs and compares them with commonly used designs. Takes the reader from simple linear regression models to advanced designs for multiple linear regression and nonlinear models in a systematic manner. Illustrates design techniques with practical examples from social and biomedical research to enhance the reader’s understanding. Researchers and students studying social, behavioural and biomedical sciences will find this book useful for understanding design issues and in putting optimal design ideas to practice.

Optimal Design of Experiments

Optimal Design of Experiments PDF Author: Friedrich Pukelsheim
Publisher: SIAM
ISBN: 0898716047
Category : Mathematics
Languages : en
Pages : 527

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Book Description
Optimal Design of Experiments offers a rare blend of linear algebra, convex analysis, and statistics. The optimal design for statistical experiments is first formulated as a concave matrix optimization problem. Using tools from convex analysis, the problem is solved generally for a wide class of optimality criteria such as D-, A-, or E-optimality. The book then offers a complementary approach that calls for the study of the symmetry properties of the design problem, exploiting such notions as matrix majorization and the Kiefer matrix ordering. The results are illustrated with optimal designs for polynomial fit models, Bayes designs, balanced incomplete block designs, exchangeable designs on the cube, rotatable designs on the sphere, and many other examples.

Theory of Optimal Designs

Theory of Optimal Designs PDF Author: Kirti R. Shah
Publisher: Springer Science & Business Media
ISBN: 1461236622
Category : Mathematics
Languages : en
Pages : 179

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Book Description
There has been an enormous growth in recent years in the literature on discrete optimal designs. The optimality problems have been formulated in various models arising in the experimental designs and substantial progress has been made towards solving some of these. The subject has now reached a stage of completeness which calls for a self-contained monograph on this topic. The aim of this monograph is to present the state of the art and to focus on more recent advances in this rapidly developing area. We start with a discussion of statistical optimality criteria in Chapter One. Chapters Two and Three deal with optimal block designs. Row-column designs are dealt with in Chapter Four. In Chapter Five we deal with optimal designs with mixed effects models. Repeated measurement designs are considered in Chapter Six. Chapter Seven deals with some special situations and Weighing designs are dis cussed in Chapter Eight. We have endeavoured to include all the major developments that have taken place in the last three decades. The book should be of use to research workers in several areas including combinatorics as well as to the experimenters in diverse fields of applications. Since the details of the construction of the designs are available in excellent books, we have only pointed out the designs which have optimality proper ties. We believe, this will be adequate for the experimenters.

Randomization in Clinical Trials

Randomization in Clinical Trials PDF Author: William F. Rosenberger
Publisher: John Wiley & Sons
ISBN: 0471654078
Category : Mathematics
Languages : en
Pages : 286

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Book Description
A unique overview that melds the concepts of conditionalprobability and stochastic processes into real-lifeapplications The role of randomization techniques in clinical trials has becomeincreasingly important. This comprehensive guide combines both theapplied aspects of randomization in clinical trials with aprobabilistic treatment of properties of randomization. Taking anunabashedly non-Bayesian and nonparametric approach to inference,the book focuses on the linear rank test under a randomizationmodel, with added discussion on likelihood-based inference as itrelates to sufficiency and ancillarity. Developments in stochasticprocesses and applied probability are also given where appropriate.Intuition is stressed over mathematics, but not without a cleardevelopment of the latter in the context of the former. Providing a consolidated review of the field, the book includesrelevant and practical discussions of: * The benefits of randomization in terms of reduction of bias * Randomization as a basis for inference * Covariate-adaptive and response-adaptive randomization * Current philosophies, controversies, and new developments With ample problem sets, theoretical exercises, and short computersimulations using SAS, Randomization in Clinical Trials: Theory andPractice is equally useful as a standard textbook in biostatisticsgraduate programs as well as a reliable reference forbiostatisticians in practice.

Public Policy and Statistics

Public Policy and Statistics PDF Author: Sally C. Morton
Publisher: Springer Science & Business Media
ISBN: 9780387987774
Category : Social Science
Languages : en
Pages : 260

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Book Description
A critical yet constructive description of the rich analytical techniques and substantive applications that typify how statistical thinking has been applied at the RAND Corporation over the past two decades. Case studies of public policy problems are useful for teaching because they are familiar: almost everyone knows something abut health insurance, global warming, and capital punishment, to name but a few of the applications covered in this casebook. Each case study has a common format that describes the policy questions, the statistical questions, and the successful and the unsuccessful analytic strategies. Readers should be familiar with basic statistical concepts including sampling and regression. While designed for statistics courses in areas ranging from economics to health policy to the law at both the advanced undergraduate and graduate levels, empirical researchers and policy-makers will also find this casebook informative.