OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 453: Combined Chronic Toxicity/Carcinogenicity Studies PDF Download
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Author: OECD
Publisher: OECD Publishing
ISBN: 9264071229
Category :
Languages : en
Pages : 20
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Book Description
The objective of a combined chronic toxicity/carcinogenicity study is to identify carcinogenic and the majority of chronic effects, and to determine dose-response relationships following prolonged and repeated exposure. The rat is typically used for ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071229
Category :
Languages : en
Pages : 20
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Book Description
The objective of a combined chronic toxicity/carcinogenicity study is to identify carcinogenic and the majority of chronic effects, and to determine dose-response relationships following prolonged and repeated exposure. The rat is typically used for ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071202
Category :
Languages : en
Pages : 18
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Book Description
The objective of these chronic toxicity studies is to characterize the profile of a substance in a mammalian species (primarily rodents) following prolonged and repeated exposure. The Test Guideline focuses on rodents and oral administration. Both ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264221476
Category :
Languages : en
Pages : 156
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Book Description
This guidance provides additional information on the conduct of studies performed using Test Guidelines 451, 452 and Test Guideline 453.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264035443
Category :
Languages : en
Pages : 12
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Book Description
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071180
Category :
Languages : en
Pages : 15
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Book Description
The objective of a long-term carcinogenicity study is to observe test animals for a major portion of their life span for the development of neoplastic lesions during or after exposure to various doses of a test substance by an appropriate route of ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264078495
Category :
Languages : en
Pages : 112
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Book Description
These Guidance Notes outline core concepts in order to obviate the need to consult large numbers of text books, while still pointing the reader to sources of more detailed or specific information.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264070702
Category :
Languages : en
Pages : 16
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Book Description
This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity has been obtained from acute or repeated dose ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264070605
Category :
Languages : en
Pages : 20
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Book Description
This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...
Author: OECD
Publisher: OECD Publishing
ISBN: 926407080X
Category :
Languages : en
Pages : 23
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Book Description
This revised Test Guideline has been designed to fully characterize test article toxicity by the inhalation route for a subchronic duration (90 days), and to provide robust data for quantitative inhalation risk assessments. Groups of 10 male and 10 ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264070729
Category :
Languages : en
Pages : 9
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Book Description
This method provides information on health hazard likely to arise from short-term exposure to test substance. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity has been ...