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Author:
Publisher: Elsevier
ISBN: 0080497217
Category : Computers
Languages : en
Pages : 527
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Book Description
The aim of Numerical Computer Methods, Part D is to brief researchers of the importance of data analysis in enzymology, and of the modern methods that have developed concomitantly with computer hardware. It is also to validate researchers' computer programs with real and synthetic data to ascertain that the results produced are what they expected. Selected Contents: Prediction of protein structure Modeling and studying proteins with molecular dynamics Statistical error in isothermal titration calorimetry Analysis of circular dichroism data Model comparison methods
Author:
Publisher: Elsevier
ISBN: 0080497217
Category : Computers
Languages : en
Pages : 527
Get Book Here
Book Description
The aim of Numerical Computer Methods, Part D is to brief researchers of the importance of data analysis in enzymology, and of the modern methods that have developed concomitantly with computer hardware. It is also to validate researchers' computer programs with real and synthetic data to ascertain that the results produced are what they expected. Selected Contents: Prediction of protein structure Modeling and studying proteins with molecular dynamics Statistical error in isothermal titration calorimetry Analysis of circular dichroism data Model comparison methods
Author: Nejat Duzgunes
Publisher: Academic Press
ISBN: 012391860X
Category : Medical
Languages : en
Pages : 503
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Book Description
This volume comprehensively covers cancer, cardiovascular and the central nervous system of nanomedicine. With an international board of authors, this volume is split into sections that cover subjects such as diabetes and nanotechnology as potential therapy, and nanomedicines for inflammatory diseases.
Author:
Publisher: Academic Press
ISBN: 0123812755
Category : Medical
Languages : en
Pages : 661
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Book Description
There are numerous excellent reviews on fragment-based drug discovery (FBDD), but there are to date no hand-holding guides or protocols with which one can embark on this orthogonal approach to complement traditional high throughput screening methodologies. This Methods in Enzymology volume offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens. The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD. Also elaborated by experienced researchers in FBDD are sample preparations of fragments, proteins, and GPCR as well as examples of how to generate leads from hits. - Offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens - The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD
Author: Theodore Friedmann
Publisher: Academic Press
ISBN: 0123865093
Category : Medical
Languages : en
Pages : 450
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Book Description
This volume of Methods in Enzymology looks at Gene Transfer Vectors for Clinical Application. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume covers such topics as General principles of retrovirus vector design, Chronic granulomatous disease (CGD), Gene therapy for blindness, and Retrovirus genetic strategy and vector design. Chapters provide an invaluable resource for academics, researchers and students alike International board of authors This volume covers such topics as general principles of retrovirus vector design, chronic granulomatous disease (CGD), gene therapy for blindness, and retrovirus genetic strategy and vector design
Author: Lynne E. Maquat
Publisher: Academic Press
ISBN: 0080922074
Category : Science
Languages : en
Pages : 661
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Book Description
Specific complexes of protein and RNA carry out many essential biological functions, including RNA processing, RNA turnover, RNA folding, as well as the translation of genetic information from mRNA into protein sequences. Messenger RNA (mRNA) decay is now emerging as an important control point and a major contributor to gene expression. Continuing identification of the protein factors and cofactors, and mRNA instability elements responsible for mRNA decay allow researchers to build a comprehensive picture of the highly orchestrated processes involved in mRNA decay and its regulation. - Covers the nonsense-mediated mRNA decay (NMD) or mRNA surveillance pathway - Expert researchers introduce the most advanced technologies and techniques to identify mRNA processing, transport, localization and turnover, which are central to the process of gene expression - Offers step-by-step lab instructions, including necessary equipment and reagents
Author: Harry Gilbert
Publisher: Academic Press
ISBN: 0124159311
Category : Medical
Languages : en
Pages : 564
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Book Description
Cellulase refers to a class of enzymes produced chiefly by fungi, bacteria, and protozoans that catalyse cellulolysis. This volume covers subjects such as 'the DNSA reducing assay for measuring cellulases', 'measuring processivity' and 'in situ cellulose detection with carbohydrate-binding modules'.
Author: Eckhard Jankowsky
Publisher: Academic Press
ISBN: 0123965462
Category : Medical
Languages : en
Pages : 590
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Book Description
This work integrates the current knowledge about RNA helicases from diverse fields ranging from cell and developmental biology to mechanistic enzymology and structural biology into one useful resource.
Author: Christopher A. Voigt
Publisher: Academic Press
ISBN: 0123851203
Category : Bioengineering
Languages : en
Pages : 557
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Book Description
Synthetic biology encompasses a variety of different approaches, methodologies and disciplines and many different definitions exist. This volume covers topics such as measuring and engineering central dogma processes, mathematical and computational methods and next-generation DNA assembly and manipulation.
Author:
Publisher: Elsevier
ISBN: 0080551386
Category : Science
Languages : en
Pages : 613
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Book Description
An integrin, or integrin receptor, is an integral membrane protein in the plasma membrane of cells. It plays a role in the attachment of a cell to the extracellular matrix (ECM) and to other cells, and in signal transduction from the ECM to the cell. There are many types of integrin, and many cells have multiple types on their surface. Integrins are of vital importance to all metazoans, from humans to sponges. This volume in Methods in Enzymology presents methods for studying integrins.
Author: P. Michael Conn
Publisher: Academic Press
ISBN: 0123884489
Category : Medical
Languages : en
Pages : 594
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Book Description
This volume of Methods in Enzymology is the second of three parts looking at current methodology for the imaging and spectroscopic analysis of live cells. The chapters provide hints and tricks not available in primary research publications. It is an invaluable resource for academics, researchers and students alike. Expert authors who are leaders in the field Extensively referenced and useful figures and tables Provides hints and tricks to facilitate reproduction of methods
