Novel Synthesis of Macrocyclic Ketolactones, and Their Utility in the Construction of Medium-sized Carbocyclic Rings Via Transannular Aldol Condensation Reactions PDF Download
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Author: Mohammad Rezaul Karim
Publisher:
ISBN:
Category : Aldol condensation
Languages : en
Pages : 528
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Book Description
Author: Mohammad Rezaul Karim
Publisher:
ISBN:
Category : Aldol condensation
Languages : en
Pages : 528
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Book Description
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 684
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Book Description
Author:
Publisher:
ISBN:
Category : Dissertation abstracts
Languages : en
Pages : 760
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Book Description
Author: American Chemical Society. Committee on Professional Training
Publisher:
ISBN:
Category : Chemical engineering
Languages : en
Pages : 1646
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Book Description
Author: Ki-Byung Chai
Publisher:
ISBN:
Category : Organic compounds
Languages : en
Pages : 1082
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Author: Sedef Karabiyikoglu
Publisher:
ISBN:
Category :
Languages : en
Pages : 391
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Book Description
Transition metal-mediated synthesis and functionalization of macrocycles were investigated. A novel synthetic strategy was discovered to build macrocyclic enynes; vic-dibromo tetrasubstituted alkenes were utilized as highly effective protected alkyne groups in selective ene-ene ring closing metathesis reactions of (E)-dibromotrienes. Macrocyclic enynes with varied sizes and functionality were synthesized in excellent yields by facile Zn-promoted deprotection of (E)-dibromodiene rings. The new strategy circumvented high catalyst loadings and reaction condition restrictions; thus, was proven superior to traditional alkyne protection methods employing dicobalt octacarbonyl complexations. Cyclic enynes were obtained in a more step-economic and efficient manner compared to classical SN2 ring closing processes. The reactivity and utility of enyne rings were showcased by platinum(II)-catalyzed transannular cyclopropanations. The first dicobalt hexacarbonyl-promoted transannular [4+2] cycloaddition reactions were demonstrated. Optimized cycloadditions for macrocyclic dicobalt-dienyne complexes afforded target tricyclic scaffolds in a more effective manner than thermal transannular Diels-Alder reactions of metal-free dienyne rings. Further, dicobalt hexacarbonyl complexes of unactivated dienophiles underwent intermolecular room temperature-[4+2] cycloadditions with unactivated dienes leading to products that are inaccessible by thermal Diels-Alder reactions. Cycloaddition reactions of complexes were highly selective; [4+2] reaction adducts were obtained stereospecifically and competing Pauson-Khand reactions were not detected. Functionalizations of enyne macrocycles through intermolecular and transannular reactions of their corresponding dicobalt complexes were studied. Novel complex polycycles were prepared by intramolecular and intermolecular [2+2+2], [2+2+1+1], [2+2+1] cycloadditions. The chemoselectivity of dicobalt-promoted cycloadditions was altered by varying the promoter and solvents utilized. The first transannular Pauson-Khand reaction was discovered. The novel synthetic method was optimized and structural requirements for reaction substrates were investigated.
Author: A. Douglas Kinghorn
Publisher: Springer Nature
ISBN: 303012858X
Category : Science
Languages : en
Pages : 455
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Book Description
This volume comprises three reviews. The first describes isolation, structure determination, syntheses, and biochemistry of the low molecular weight compounds of the secretion of exocrine glands of termies with emphasis to pheromones and defensive compounds. The second review describes recent studies on isolation and structure elucidation of bioactive compounds involved in the life cycle and determination of the molecular mechanisms of the developmental events observed in higher plants. The third contribution reports on the current body of knowledge of African propolis, with a particular emphasis on its chemistry and biological activity.
Author: George S. Zweifel
Publisher: John Wiley & Sons
ISBN: 1119086760
Category : Science
Languages : en
Pages : 416
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Book Description
This book bridges the gap between sophomore and advanced / graduate level organic chemistry courses, providing students with a necessary background to begin research in either an industry or academic environment. • Covers key concepts that include retrosynthesis, conformational analysis, and functional group transformations as well as presents the latest developments in organometallic chemistry and C–C bond formation • Uses a concise and easy-to-read style, with many illustrated examples • Updates material, examples, and references from the first edition • Adds coverage of organocatalysts and organometallic reagents
Author: Richard D. Chambers
Publisher: CRC Press
ISBN: 9780849317903
Category : Science
Languages : en
Pages : 426
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Book Description
The introduction of carbon-fluorine bonds into organic compounds can profoundly influence their chemical and physical properties when compared to their non-fluorine-containing analogues, leading to a range of man-made materials with highly desirable properties. These molecules are of interest across the wide spectrum of industrial and academic organic chemistry, from pharmaceuticals, through fine and specialty chemicals to polymers. From Prozac to Teflon, many of the most important products of the chemical and life-science industries rely on organic fluorine chemistry for their useful properties. This book covers both the preparative methodologies and chemical properties of partially and highly fluorinated organic systems.
Author: Reinhard W. Hoffmann
Publisher: Elsevier
ISBN: 0323162800
Category : Science
Languages : en
Pages : 399
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Book Description
Dehydrobenzene and Cycloalkynes deals with the problems associated with the production and reactions of dehydrobenzene and of the related fields of dehydroheterocycles and cycloalkynes. This book also describes the various synthetic applications of dehydrobenzene and provides a list of reactions in which dehydrobenzene occurs as an intermediary. The text explains the generation of dehydrobenzene by cleavage of cyclic systems, by photolytic methods, and by free radical reactions. Nucleophilic and electrophilic monodentate attacks on dehydrobenzene, as well as, bidentate additions to dehydrobenzene yielding cycloadducts. The book also notes that dehydrobenzene is not only a transition state but can be an intermediate of characteristic selectivity and lifetime. The reactions of dehydrobenzene in the gaseous phase affirm that the existence of dehydrobenzene is not restricted to the presence of a solvation shell. The researcher can then study the molecular structure of dehydrobenzene when its existence has been fully established. The text also extends the principle that the dehydroaromatic intermediates can be obtained by abstracting two adjacent hydrogen atoms from an aromatic substrate different from the 1- and 2- positions to arrive at a 1,3- and 1,4-dehydrobenzene. Researchers and scientists whose works are associated with organic chemistry, analytical chemistry, molecular physics or physical chemistry will find this book valuable.
