Novel Strategy for the Synthesis of Substituted Five-membered N-heterocycles PDF Download
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Author: Víctor Samper Barceló
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Víctor Samper Barceló
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: M. R. Yadav
Publisher: Elsevier
ISBN: 0081022492
Category : Science
Languages : en
Pages : 432
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Book Description
Vicinal Diaryl-Substituted Heterocycles: A Gold Mine for the Discovery of Novel Therapeutic Agents draws together all of the key information about these compounds in one place for the first time. Following an informative overview of the importance of these structures to the discovery of potential therapeutic agents, the text goes on to outline the main compound types, with each chapter focusing on the activities of a different structure. Designed to support researchers by consolidating this important information in a single, practical guide, the authors hope to encourage further advancement and development in the discovery of novel therapeutic agents. As flexible building blocks for the production of novel compounds, vicinal diaryl-substituted heterocycles are a rich source of leads for the development of new drugs. Their adaptability means that they can be used to produce structures with a broad range of attractive characteristics, and a large number of vicinal diaryl-substituted heterocyclic compounds have already been synthesized and investigated by medicinal chemists as promising lead molecules. - Collects together details of the key vicinal diaryl-substituted heterocyclic compounds in one place for the first time - Highlights biological activities and SAR of derivatives - Structured practically for ease of navigation between different derivatives
Author: Chanitsara Kocharit
Publisher:
ISBN:
Category :
Languages : en
Pages : 312
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Book Description
Author: Aaron Keeley
Publisher:
ISBN:
Category : Heterocyclic compounds
Languages : en
Pages : 72
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Author: Aimee Lynn Crombie
Publisher:
ISBN:
Category :
Languages : en
Pages : 355
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Book Description
Highly convergent annulation strategies have been developed for the synthesis of azulenes and polycyclic nitrogen heterocycles. Specifically, substituted azulenes have been synthesized via a ring expansion-annulation strategy based on n-halo diazo ketones. The method employs the use of readily available benzenoid starting materials and achieves the synthesis of azulenes substituted on both the five- and seven-membered rings regioselectively. The synthetic utility of the ring expansion annulation products, in particular azulenyl halides and triflates, has been demonstrated by their successful application in transition metal-mediated carbon-carbon bond forming reactions. These reactions have been used to further functionalize the five- and seven-membered rings and also in the synthesis of oligoazulenes and azulenylamino acid derivatives. In addition, polycyclic nitrogen heterocycles have been synthesized via a tandem ring forming strategy. The strategy employs a novel benzannulation reaction of substituted cyclobutenones with ynamides, which are synthesized via the strategy for the N-alkynylation of amides strategy developed in the Danheiser laboratory. The products of these benzannulation reactions, highly-substituted anilines, then participate in ring closing metathesis reactions to form various nitrogen heterocycles. In particular dihydroquinolines, hydrobenzoazepines, and hydrobenzoazocines were synthesized via this tandem ynamide benzannulation ring closing metathesis strategy.
Author: American Chemical Society. Meeting
Publisher:
ISBN:
Category : Language Arts & Disciplines
Languages : en
Pages : 390
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Book Description
This is the first ACS symposium series book solely devoted to fluorinated heterocyclic compounds. Its contents encompasses all aspects of chemistry and applications of fluoroheterocycles including synthesis, biological activity, computational and medicinal research covering all major classes of heterocycles as well as popular fluorine-containing fragments.
Author: Alan R. Katritzky
Publisher: Academic Press
ISBN:
Category : Medical
Languages : en
Pages : 768
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Book Description
Heterocyclic chemistry is the largest of the classical divisions of organic chemistry. Heterocyclic compounds are widely distributed in Nature, playing a vital role in the metabolism of living cells. Their practical applications range from extensive clinical use to fields as diverse as agriculture, photography, biocide formulation and polymer science. The range of known compounds is enormous, encompassing the whole spectrum of physical, chemical and biological properties. This book provides a balanced, concise and informative account of heterocyclic chemistry that will be suitable for graduate or advanced undergraduate students and a convenient reference book for research workers, for both specialists int he field and those whose expertise lies in other areas but who nevertheless need information on heterocylic chemistry. The Handbook of Heterocyclic Chemistry is illustrated throughout with thousands of clearly drawn chemical structures. The highly systematic coverage given to the subject makes this the most authoritative one-volume account of modern heterocyclic chemistry available. Provides a balanced, concise and informative account of heterocyclic chemistry Written by leading scholars and industry experts Illustrated throughout with thousands of clearly drawn chemical structures The most authoritative one-volume account of modern heterocyclic chemistry available
Author: Navjeet Kaur
Publisher: CRC Press
ISBN: 1351242601
Category : Medical
Languages : en
Pages : 432
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Book Description
This book is a compilation of the recent applications of palladium catalysts in organic synthesis. The book demonstrates that it is a highly dynamic research field. This methodology has emerged as a powerful tool for the efficient and chemoselective synthesis of heterocyclic molecules. In the past few years, several strategies have been pointed out to pursue more efficient, sustainable, and environment friendly chemical processes. Among those strategies, catalysis and the design of new processes that avoid the use of toxic reagents have been the focus of intense research.
Author: G Pattenden
Publisher: Royal Society of Chemistry
ISBN: 184755623X
Category : Science
Languages : en
Pages : 716
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Book Description
Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.
Author: Gordon W. Gribble
Publisher: Springer
ISBN: 364231791X
Category : Science
Languages : en
Pages : 456
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Book Description
T. L.S. Kishbaugh: Metalation of Pyrrole.- K.-S. Yeung: Furans and Benzofurans.- P. E. Alford: Lithiation-Based and Magnesation-Based Strategies for the Functionalization of Imidazole: 2001–2010.- L. Fu: Metalation of Oxazoles and Benzoxazoles.- S. Roy • S. Roy • G. W. Gribble: Metalation of Pyrazoles and Indazoles.- J. C. Badenock: Metalation Reactions of Isoxazoles and Benzisoxazoles.- Y.-J. Wu: Thiazoles and Benzothiazoles.- C. F. Nutaitis: Isothiazoles and Benzisothiazoles.- E. R. Biehl: Recent Advances in the Synthesis of Thiophenes and Benzothiophenes.- J. M. Lopchuk: Mesoionics.- J. M. Lopchuk: Azoles with 3-4 Heteroatoms.
