Novel Strategies in the Chemistry of N-Amino Heterocycles PDF Download
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Author: Davit Jishkariani
Publisher:
ISBN:
Category :
Languages : en
Pages : 99
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Book Description
The theme of this work is to develop n ove l methodologies for the synthesis of various organic compounds . Chapter 1 provides a general introduction to the subsequent chapters and the methods used throughout the thesis. Chapter 2 describes the utility of N - acylbenzotriazoles for the synthesis of ib uprofen and naproxen prodrugs. Chapters 3, 4, and 5 examine the chemistry of N - amino heterocycles. Chapter 3 describes the synthesis of 1 - aminobenzimidazoles and their transformations towards zwitterionic betaines and spirocyclic dithiohydantoins mediated by N - heterocyclic carbenes (NHC). The reversible thermal equilibrium of these spirocyclic dithiohydantoins is presented in Chapter 4, where the equilibrium is studied by various analytical methods. Chapter 5 focuses on the regioselective synthesis of p yra zolo[5,1 - c] - 1,2,4 - triazoles. Synthesis of pyrazolo[5,1 - c] - 1,2,4 - triazoles w as achieved via one - pot Cu (I) catalyzed reactions between 1,2,4 - triazolium N - imides and terminal alkynes . T he scope of alkyne substrates together with the effect of variations in t he 1 - alkyl substituent and the nature of the leaving group w as examined. 16 Conclusions, summary of the achievements and final remarks are presented in Chapter 6.
Author: Davit Jishkariani
Publisher:
ISBN:
Category :
Languages : en
Pages : 99
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Book Description
The theme of this work is to develop n ove l methodologies for the synthesis of various organic compounds . Chapter 1 provides a general introduction to the subsequent chapters and the methods used throughout the thesis. Chapter 2 describes the utility of N - acylbenzotriazoles for the synthesis of ib uprofen and naproxen prodrugs. Chapters 3, 4, and 5 examine the chemistry of N - amino heterocycles. Chapter 3 describes the synthesis of 1 - aminobenzimidazoles and their transformations towards zwitterionic betaines and spirocyclic dithiohydantoins mediated by N - heterocyclic carbenes (NHC). The reversible thermal equilibrium of these spirocyclic dithiohydantoins is presented in Chapter 4, where the equilibrium is studied by various analytical methods. Chapter 5 focuses on the regioselective synthesis of p yra zolo[5,1 - c] - 1,2,4 - triazoles. Synthesis of pyrazolo[5,1 - c] - 1,2,4 - triazoles w as achieved via one - pot Cu (I) catalyzed reactions between 1,2,4 - triazolium N - imides and terminal alkynes . T he scope of alkyne substrates together with the effect of variations in t he 1 - alkyl substituent and the nature of the leaving group w as examined. 16 Conclusions, summary of the achievements and final remarks are presented in Chapter 6.
Author: Aaron Keeley
Publisher:
ISBN:
Category : Heterocyclic compounds
Languages : en
Pages : 72
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Book Description
Author: Ana Maria Faisca Phillips
Publisher: John Wiley & Sons
ISBN: 1119757142
Category : Science
Languages : en
Pages : 759
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Book Description
More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles An authoritative collection of resources discussing the latest trends in the synthesis of nonaromatic nitrogen heterocycles Widely distributed in nature, nitrogen heterocycles are extremely common in synthetic substances found in pharmaceuticals, agrochemicals, and materials. The literature is evolving rapidly and explores newly emerging structures and medicines. More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles offers R&D professionals the opportunity to easily access a collection of the latest relevant research in the area. In the second two-volume set of this practical reference distinguished researcher Dr. Ana Maria M. M. Faisca Phillips delivers a collection of resources focusing on the newest and most widely applicable trends emerging in synthetic strategies for nonaromatic nitrogen heterocycles. With coverage of topics including organocatalysis, cascade reactions, flow chemistry in synthesis, cycloaddition reactions, metathesis, cross-coupling reactions, and electrochemistry, the book provides quick access to critical new avenues of synthesis. More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles: Volume 1 and 2 also offers readers: A thorough introduction to recent advances in the design and synthesis of cyclic peptidomimetics Comprehensive explorations of fused heterocycles and transition metal promoted synthesis of isoindoline derivatives Practical discussions of 1,4-diazepane ring-based systems and recent advances in the synthesis of azepane-based compounds In-depth examinations of strained aziridinium ions, asymmetric organocatalysis in alternative media, and the electrochemical synthesis of non-aromatic N-heterocycles Perfect for academic and industrial researchers in organic chemistry and synthesis, organometallic chemistry, pharmaceutical chemistry catalysis, and sustainable chemistry, More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles: Volume 1 and 2 is an indispensable reference for anyone seeking an authoritative source of information on new and emerging trends in synthesis.
Author: Ana Maria Faisca Phillips
Publisher: John Wiley & Sons
ISBN: 1119757126
Category : Science
Languages : en
Pages : 759
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Book Description
More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles An authoritative collection of resources discussing the latest trends in the synthesis of nonaromatic nitrogen heterocycles Widely distributed in nature, nitrogen heterocycles are extremely common in synthetic substances found in pharmaceuticals, agrochemicals, and materials. The literature is evolving rapidly and explores newly emerging structures and medicines. More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles offers R&D professionals the opportunity to easily access a collection of the latest relevant research in the area. In the second two-volume set of this practical reference distinguished researcher Dr. Ana Maria M. M. Faisca Phillips delivers a collection of resources focusing on the newest and most widely applicable trends emerging in synthetic strategies for nonaromatic nitrogen heterocycles. With coverage of topics including organocatalysis, cascade reactions, flow chemistry in synthesis, cycloaddition reactions, metathesis, cross-coupling reactions, and electrochemistry, the book provides quick access to critical new avenues of synthesis. More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles: Volume 1 and 2 also offers readers: A thorough introduction to recent advances in the design and synthesis of cyclic peptidomimetics Comprehensive explorations of fused heterocycles and transition metal promoted synthesis of isoindoline derivatives Practical discussions of 1,4-diazepane ring-based systems and recent advances in the synthesis of azepane-based compounds In-depth examinations of strained aziridinium ions, asymmetric organocatalysis in alternative media, and the electrochemical synthesis of non-aromatic N-heterocycles Perfect for academic and industrial researchers in organic chemistry and synthesis, organometallic chemistry, pharmaceutical chemistry catalysis, and sustainable chemistry, More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles: Volume 1 and 2 is an indispensable reference for anyone seeking an authoritative source of information on new and emerging trends in synthesis.
Author: Romano V. A. Orru
Publisher: Springer Science & Business Media
ISBN: 364212674X
Category : Science
Languages : en
Pages : 292
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Book Description
Contents: L. Banfi ∙ A. Basso ∙ R. Riva: Synthesis of Heterocycles Through Classical Ugi and Passerini Reactions Followed by Secondary Transformations Involving One or Two Additional Functional Groups.- V.A. Chebanov ∙ K. A. Gura ∙ S.M. Desenko: Aminoazoles as Key Reagents in Multicomponent Heterocyclizations.- Y. Huang ∙ K. Khoury ∙ A. Dömling: Piperazine Scaffolds by Multicomponent 3 Reactions: The Piperazine Space 4 in MCR Chemistry 5 Deep MCR Piperazine Space.- N. Elders ∙ E. Ruijter ∙ V.G. Nenajdenko ∙ R.V.A. Orru: α-Acidic Isocyanides in Multicomponent Chemistry.- A. Cukalovic ∙ J.-C.M.R. Monbaliu ∙ C.V. Stevens: Microreactor Technology as an Efficient Tool for Multicomponent Reactions.- L.A. Wessjohann ∙ C.R.B. Rhoden ∙ D.G. Rivera ∙ O. Eichler Vercillo: Cyclic Peptidomimetics and Pseudopeptides from Multicomponent Reactions.- M. del Mar Sanchez Duque ∙ C. Allais ∙ N. Isambert ∙ T. Constantieux ∙ J. Rodriguez: ß-Diketo Building Blocks for MCRs-Based Syntheses of Heterocycles
Author: Víctor Samper Barceló
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Keshav Lalit Ameta
Publisher: Springer Nature
ISBN: 981190832X
Category : Science
Languages : en
Pages : 465
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Book Description
This book presents an overview of the recent advancements for the synthesis of small- and medium-sized azaheterocycles, including pyrroles, indoles, pyrimidines, pyridines, pyrrolidines, imidazoles, pyrazoles, pyrazolines, lactams, and 1,2,3-triazoles, which are significant scaffolds for compounds with pharmaceutical uses. The book also discusses various properties and performance attributes of azaheterocycles including their bioactivity and synthetic strategies. Given the contents, the book will be a valuable reference for students, researchers, and professionals interested in organic synthesis and medicinal chemistry.
Author: Thomas M. Klapötke
Publisher: Springer
ISBN: 3540722025
Category : Science
Languages : en
Pages : 292
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Book Description
Author: Galal H. Elgemeie
Publisher: Elsevier
ISBN: 0128221828
Category : Science
Languages : en
Pages : 523
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Book Description
N-Sulfonated-N-Heterocycles covers the synthesis, chemistry and biological applications of these compounds, focusing on pioneering synthetic approaches, mechanistic insights and their limitations, as well as recent advances in this field. The synthesis of some of N-sulfonated N-heterocycles and their transformation to other useful cyclic and acyclic compounds are discussed, as well as their uses as useful intermediates in the preparation of polymeric and medicinal materials. This book includes detailed methods and protocols, and the focus on applications makes this resource an essential guide for all researchers in the area of organic, medicinal and polymeric synthetic study. - Reviews the use of N-sulfonated N-heterocycles as important precursors for the synthesis of biologically active compounds - Includes information on synthetically useful transformations of N-sulfonated N-heterocycles - Covers a wide synthetic methods used for an important branch of heterocycles and their biological evaluation in detail - Features over 500 schemes to illustrate different synthetic pathways and reactions of N-sulfonated N-heterocycles
Author: Goutam Brahmachari
Publisher: Elsevier
ISBN: 0128205865
Category : Science
Languages : en
Pages : 642
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Book Description
Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. Provides fully updated coverage of the field of greener heterocycle synthesis Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches Presents information in an accessible style with an emphasis on sustainability
