Novel Immunotherapeutics Aimed at Neutralizing PD1 Mediated Immune Suppression PDF Download
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Author: Lucas Horn
Publisher:
ISBN:
Category :
Languages : en
Pages : 472
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Book Description
Tumor cells employ various immune suppressive strategies to overcome anti-tumor immunity. One such method is mediated by programmed death ligand-1 (PDL1), which triggers apoptotic death or anergy upon binding programmed death-1 (PD1) on T cells. Researchers have been developing immunotherapies that target PDL1 on tumor cells or PD1 on T cells to reverse tumor mediated immune suppression and reactivate an anti-tumor T cell response. We hypothesize novel single reagents such as CD80-Fc and CD3xPDL1 BiTE can be generated that combine multiple immune mechanisms in a single drug which could replace or add to existing immune modulating monotherapies. The research goals were to understand the mechanisms by which novel immunotherapeutic drugs reverse tumor mediated immune suppression and stimulate an antitumor, T cell mediated immune response. This included testing of how these drugs mediate their effects and assessing their potency in animal models.
Author: Lucas Horn
Publisher:
ISBN:
Category :
Languages : en
Pages : 472
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Book Description
Tumor cells employ various immune suppressive strategies to overcome anti-tumor immunity. One such method is mediated by programmed death ligand-1 (PDL1), which triggers apoptotic death or anergy upon binding programmed death-1 (PD1) on T cells. Researchers have been developing immunotherapies that target PDL1 on tumor cells or PD1 on T cells to reverse tumor mediated immune suppression and reactivate an anti-tumor T cell response. We hypothesize novel single reagents such as CD80-Fc and CD3xPDL1 BiTE can be generated that combine multiple immune mechanisms in a single drug which could replace or add to existing immune modulating monotherapies. The research goals were to understand the mechanisms by which novel immunotherapeutic drugs reverse tumor mediated immune suppression and stimulate an antitumor, T cell mediated immune response. This included testing of how these drugs mediate their effects and assessing their potency in animal models.
Author: Tim F. Greten
Publisher: Springer
ISBN: 9783319879116
Category : Medical
Languages : en
Pages : 0
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Book Description
In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.
Author: L.E. Samelson
Publisher:
ISBN: 9783318018981
Category : Medical
Languages : en
Pages : 0
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Book Description
Author: Aung Naing
Publisher: Springer Nature
ISBN: 3030793087
Category : Medical
Languages : en
Pages : 445
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Book Description
The field of immuno-oncology continues to rapidly evolve as new insights to fight and treat cancer emerge. The fourth edition of Immunotherapy provides the most current overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. While immunotherapy has revolutionized the treatment landscape of several solid malignancies, several challenges still exist. Only a subset of patients derive clinical benefits; some do not respond at all, and others respond initially, only for their disease to progress later. Because these drugs can activate a broad range of immune cells, patients suffer from a unique set of side effects known as immune-related adverse events. As more immunotherapeutic agents are used in the clinic, it is important to provide updates about current and ongoing developments in the field to further research efforts and inform treatment decisions. The fourth edition will have a new focus on strategies to overcome the challenges associated with immunotherapy. Chapters will discuss topics such as biomarkers of response, resistance mechanisms, role of imaging in predicting immune-related adverse events, and management of immune-related adverse events. Written by leading experts conducting cutting-edge research, readers will gain up-to-date knowledge on the current state and future of immunotherapy.
Author: Udo S. Gaipl
Publisher: Frontiers Media SA
ISBN: 2889636151
Category :
Languages : en
Pages : 144
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Book Description
Author: Laurence Zitvogel
Publisher: Springer
ISBN: 3319624318
Category : Medical
Languages : en
Pages : 700
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Book Description
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
Author: Virginie Lafont
Publisher: Frontiers Media SA
ISBN: 2889669459
Category : Medical
Languages : en
Pages : 182
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Book Description
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309220424
Category : Science
Languages : en
Pages : 200
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Book Description
For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.
Author: Yongsheng Li
Publisher: Springer
ISBN: 9789813367876
Category : Medical
Languages : en
Pages : 211
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Book Description
This book focuses on lipid metabolism in tumor immunity, covering the application of lipidomics in tumor immunity and all aspects of lipid metabolism in tumor microenvironment. During the progression of tumors, tumor cells and immune cells interact in a dynamic microenvironment. Targeting the immune system has a high potential for treating cancer. However, due to the high heterogeneity of the tumor microenvironment, only a small percentage of patients experience such clinical benefits of tumor immunotherapy. Therefore, understanding the tumor microenvironment is crucial for tumor immunity. Recently, lipid metabolism is an emerging research direction and contributes to cell survival and biofunctions in tumor microenvironment, which is of great interest and significance to be elucidated. This book provides the doctors, researchers, and scientists with a cutting-edge overview of the lipid metabolism and its role in tumor immunity. It also yields benefits for pharmaceutical companies regarding drug discovery.
Author: Suzanne L. Walker
Publisher:
ISBN: 9781635930184
Category :
Languages : en
Pages :
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Book Description
