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Author: José C. Pinheiro
Publisher: Springer Science & Business Media
ISBN: 1441903178
Category : Computers
Languages : en
Pages : 538
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Book Description
R, linear models, random, fixed, data, analysis, fit.
Author: José C. Pinheiro
Publisher: Springer Science & Business Media
ISBN: 1441903178
Category : Computers
Languages : en
Pages : 538
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Book Description
R, linear models, random, fixed, data, analysis, fit.
Author: Tatiana V Tatarinova
Publisher: World Scientific
ISBN: 1783266279
Category : Mathematics
Languages : en
Pages : 296
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Book Description
This book, written by two mathematicians from the University of Southern California, provides a broad introduction to the important subject of nonlinear mixture models from a Bayesian perspective. It contains background material, a brief description of Markov chain theory, as well as novel algorithms and their applications. It is self-contained and unified in presentation, which makes it ideal for use as an advanced textbook by graduate students and as a reference for independent researchers. The explanations in the book are detailed enough to capture the interest of the curious reader, and complete enough to provide the necessary background material needed to go further into the subject and explore the research literature.In this book the authors present Bayesian methods of analysis for nonlinear, hierarchical mixture models, with a finite, but possibly unknown, number of components. These methods are then applied to various problems including population pharmacokinetics and gene expression analysis. In population pharmacokinetics, the nonlinear mixture model, based on previous clinical data, becomes the prior distribution for individual therapy. For gene expression data, one application included in the book is to determine which genes should be associated with the same component of the mixture (also known as a clustering problem). The book also contains examples of computer programs written in BUGS. This is the first book of its kind to cover many of the topics in this field.
Author: Jeffrey Robert Harring
Publisher:
ISBN:
Category :
Languages : en
Pages : 304
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Book Description
Author: Edward Vonesh
Publisher: CRC Press
ISBN: 9780824782481
Category : Mathematics
Languages : en
Pages : 590
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Book Description
Integrates the latest theory, methodology and applications related to the design and analysis of repeated measurement. The text covers a broad range of topics, including the analysis of repeated measures design, general crossover designs, and linear and nonlinear regression models. It also contains a 3.5 IBM compatible disk, with software to implement immediately the techniques.
Author: Joel S. Owen
Publisher: John Wiley & Sons
ISBN: 9780470582299
Category : Medical
Languages : en
Pages : 0
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Book Description
This book provides a user-friendly, hands-on introduction to the Nonlinear Mixed Effects Modeling (NONMEM) system, the most powerful tool for pharmacokinetic / pharmacodynamic analysis. • Introduces requisite background to using Nonlinear Mixed Effects Modeling (NONMEM), covering data requirements, model building and evaluation, and quality control aspects • Provides examples of nonlinear modeling concepts and estimation basics with discussion on the model building process and applications of empirical Bayesian estimates in the drug development environment • Includes detailed chapters on data set structure, developing control streams for modeling and simulation, model applications, interpretation of NONMEM output and results, and quality control • Has datasets, programming code, and practice exercises with solutions, available on a supplementary website
Author: Miodrag Lovric
Publisher: Springer Science & Business Media
ISBN: 3642048978
Category : Mathematics
Languages : en
Pages : 0
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Book Description
The goal of this book is multidimensional: a) to help reviving Statistics education in many parts in the world where it is in crisis. For the first time authors from many developing countries have an opportunity to write together with the most prominent world authorities. The editor has spent several years searching for the most reputable statisticians all over the world. International contributors are either presidents of the local statistical societies, or head of the Statistics department at the main university, or the most distinguished statisticians in their countries. b) to enable any non-statistician to obtain quick and yet comprehensive and highly understandable view on certain statistical term, method or application c) to enable all the researchers, managers and practicioners to refresh their knowledge in Statistics, especially in certain controversial fields. d) to revive interest in statistics among students, since they will see its usefulness and relevance in almost all branches of Science.
Author: Marie Davidian
Publisher: Routledge
ISBN: 1351428152
Category : Mathematics
Languages : en
Pages : 360
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Book Description
Nonlinear measurement data arise in a wide variety of biological and biomedical applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the analysis of assay and laboratory data. Nonlinear Models for Repeated Measurement Data provides the first unified development of methods and models for data of this type, with a detailed treatment of inference for the nonlinear mixed effects and its extensions. A particular strength of the book is the inclusion of several detailed case studies from the areas of population pharmacokinetics and pharmacodynamics, immunoassay and bioassay development and the analysis of growth curves.
Author: Lang Wu
Publisher: CRC Press
ISBN: 9781420074086
Category : Mathematics
Languages : en
Pages : 431
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Book Description
Although standard mixed effects models are useful in a range of studies, other approaches must often be used in correlation with them when studying complex or incomplete data. Mixed Effects Models for Complex Data discusses commonly used mixed effects models and presents appropriate approaches to address dropouts, missing data, measurement errors, censoring, and outliers. For each class of mixed effects model, the author reviews the corresponding class of regression model for cross-sectional data. An overview of general models and methods, along with motivating examples After presenting real data examples and outlining general approaches to the analysis of longitudinal/clustered data and incomplete data, the book introduces linear mixed effects (LME) models, generalized linear mixed models (GLMMs), nonlinear mixed effects (NLME) models, and semiparametric and nonparametric mixed effects models. It also includes general approaches for the analysis of complex data with missing values, measurement errors, censoring, and outliers. Self-contained coverage of specific topics Subsequent chapters delve more deeply into missing data problems, covariate measurement errors, and censored responses in mixed effects models. Focusing on incomplete data, the book also covers survival and frailty models, joint models of survival and longitudinal data, robust methods for mixed effects models, marginal generalized estimating equation (GEE) models for longitudinal or clustered data, and Bayesian methods for mixed effects models. Background material In the appendix, the author provides background information, such as likelihood theory, the Gibbs sampler, rejection and importance sampling methods, numerical integration methods, optimization methods, bootstrap, and matrix algebra. Failure to properly address missing data, measurement errors, and other issues in statistical analyses can lead to severely biased or misleading results. This book explores the biases that arise when naïve methods are used and shows which approaches should be used to achieve accurate results in longitudinal data analysis.
Author: Pierre Comon
Publisher: Academic Press
ISBN: 0080884946
Category : Technology & Engineering
Languages : en
Pages : 856
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Book Description
Edited by the people who were forerunners in creating the field, together with contributions from 34 leading international experts, this handbook provides the definitive reference on Blind Source Separation, giving a broad and comprehensive description of all the core principles and methods, numerical algorithms and major applications in the fields of telecommunications, biomedical engineering and audio, acoustic and speech processing. Going beyond a machine learning perspective, the book reflects recent results in signal processing and numerical analysis, and includes topics such as optimization criteria, mathematical tools, the design of numerical algorithms, convolutive mixtures, and time frequency approaches. This Handbook is an ideal reference for university researchers, R&D engineers and graduates wishing to learn the core principles, methods, algorithms, and applications of Blind Source Separation. Covers the principles and major techniques and methods in one book Edited by the pioneers in the field with contributions from 34 of the world’s experts Describes the main existing numerical algorithms and gives practical advice on their design Covers the latest cutting edge topics: second order methods; algebraic identification of under-determined mixtures, time-frequency methods, Bayesian approaches, blind identification under non negativity approaches, semi-blind methods for communications Shows the applications of the methods to key application areas such as telecommunications, biomedical engineering, speech, acoustic, audio and music processing, while also giving a general method for developing applications
Author: Andrzej Gałecki
Publisher: Springer Science & Business Media
ISBN: 1461439000
Category : Mathematics
Languages : en
Pages : 558
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Book Description
Linear mixed-effects models (LMMs) are an important class of statistical models that can be used to analyze correlated data. Such data are encountered in a variety of fields including biostatistics, public health, psychometrics, educational measurement, and sociology. This book aims to support a wide range of uses for the models by applied researchers in those and other fields by providing state-of-the-art descriptions of the implementation of LMMs in R. To help readers to get familiar with the features of the models and the details of carrying them out in R, the book includes a review of the most important theoretical concepts of the models. The presentation connects theory, software and applications. It is built up incrementally, starting with a summary of the concepts underlying simpler classes of linear models like the classical regression model, and carrying them forward to LMMs. A similar step-by-step approach is used to describe the R tools for LMMs. All the classes of linear models presented in the book are illustrated using real-life data. The book also introduces several novel R tools for LMMs, including new class of variance-covariance structure for random-effects, methods for influence diagnostics and for power calculations. They are included into an R package that should assist the readers in applying these and other methods presented in this text.
