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Author: Qian Wang
Publisher:
ISBN:
Category :
Languages : en
Pages : 196
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Book Description
The development of new chromatographic materials is a very active field within separation sciences providing improved efficiency for current separation methods and allowing the realization of new ones. The work presented in this dissertation focuses on the development of two new chromatographic materials: a stationary phase based on surface confined ionic liquids and hafnia support monolithic columns for chromatography. Silica particles were chemically modified with methoxysilane derivatives: 1-methyl-3-(trimethoxysilylpropyl)imidazolium bromide and 1-butyl-3-(trimethoxysilylpropyl)imidazolium bromide and used as the stationary phase for HPLC. The modified silica was characterized by thermogravimetric analysis (TGA) and NMR spectroscopy. The ionic liquid moiety was predominantly attached to the silica surface through two silanoxane bonds of the silane derivative. Columns packed with the modified silica material were tested under HPLC conditions. Evaluation of the stationary phase for HPLC was performed using aromatic carboxylic acids as model compounds. The separation mechanism appears to involve multiple interactions including ion exchange, hydrophobic interaction, and other electrostatic interactions. A monolithic column consists of a porous structure inside of a tube (or channel) that forms a continuous bed of chromatographic material. These type of columns present an alternative to packed columns due to their high permeability, absence of frits to confine the packing material, and ease of fabrication. The most common monoliths are based on silica support, polystyrene or polymethacrylate polymeric structures, or acrylamide gels. A new type of monolithic structures based on hafnium oxide (i.e., hafnia) was synthesized using a sol-gel process. The processing reactions and conditions were studied using different analytical methodologies (i.e., pH measurement, FTIR and NMR spectroscopy), in an effort to understand the critical parameters leading to the hafnia monolithic structure. This would allow control of the synthetic conditions to provide materials with desired physicochemical characteristics that can have an impact on chromatographic performance. To understand the sol-gel process in the solution phase, a 177 Hf NMR method was developed to conduct the study of the aqueous chemistry of Hf(IV); to the best of our knowledge, this is the first observation of the 177 Hf NMR signal. Characterization of the hafnia monolithic structure was also performed using TGA, fluorescence spectroscopy and XRD.
Author: Qian Wang
Publisher:
ISBN:
Category :
Languages : en
Pages : 196
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Book Description
The development of new chromatographic materials is a very active field within separation sciences providing improved efficiency for current separation methods and allowing the realization of new ones. The work presented in this dissertation focuses on the development of two new chromatographic materials: a stationary phase based on surface confined ionic liquids and hafnia support monolithic columns for chromatography. Silica particles were chemically modified with methoxysilane derivatives: 1-methyl-3-(trimethoxysilylpropyl)imidazolium bromide and 1-butyl-3-(trimethoxysilylpropyl)imidazolium bromide and used as the stationary phase for HPLC. The modified silica was characterized by thermogravimetric analysis (TGA) and NMR spectroscopy. The ionic liquid moiety was predominantly attached to the silica surface through two silanoxane bonds of the silane derivative. Columns packed with the modified silica material were tested under HPLC conditions. Evaluation of the stationary phase for HPLC was performed using aromatic carboxylic acids as model compounds. The separation mechanism appears to involve multiple interactions including ion exchange, hydrophobic interaction, and other electrostatic interactions. A monolithic column consists of a porous structure inside of a tube (or channel) that forms a continuous bed of chromatographic material. These type of columns present an alternative to packed columns due to their high permeability, absence of frits to confine the packing material, and ease of fabrication. The most common monoliths are based on silica support, polystyrene or polymethacrylate polymeric structures, or acrylamide gels. A new type of monolithic structures based on hafnium oxide (i.e., hafnia) was synthesized using a sol-gel process. The processing reactions and conditions were studied using different analytical methodologies (i.e., pH measurement, FTIR and NMR spectroscopy), in an effort to understand the critical parameters leading to the hafnia monolithic structure. This would allow control of the synthetic conditions to provide materials with desired physicochemical characteristics that can have an impact on chromatographic performance. To understand the sol-gel process in the solution phase, a 177 Hf NMR method was developed to conduct the study of the aqueous chemistry of Hf(IV); to the best of our knowledge, this is the first observation of the 177 Hf NMR signal. Characterization of the hafnia monolithic structure was also performed using TGA, fluorescence spectroscopy and XRD.
Author: K. Hostettmann
Publisher: Springer Science & Business Media
ISBN: 3662036312
Category : Science
Languages : en
Pages : 259
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Book Description
Over the past few years, increasing attention has been paid to the search for bioactive compounds from natural sources. The success of plant-derived products such as paclitaxel (Taxol) in tumor therapy or artemisinin in the treatment of malaria has provided the impetus for the introduction of numerous research programmes, especially in Industry. A great deal of effort is being expended in the generation of novel lead molecules of vegetable, marine and microbial origin by the use of high throughput screening protocols. When interesting hits are found, it is essen tial to have methods available for the rapid isolation of target compounds. For this reason, both industry and academia need efficient preparative chromatographic separation techniques and experience in their application. Purified natural products are required for complete spectro scopic identification and full characterization of new compo unds, for biological testing and for the supply of pharmaceuti cals, standards, and starting materials for synthetic work. Obtaining pure products from an extract can be a very long, te dious and expensive undertaking, involving many steps. Sometimes only minute amounts of the desired compounds are at hand and these entities may be labile. Thus it is an advantage to have access to as many different methods as possible in order to aid the isolation process. Although a certain amount of trial and error may be involved, nowadays there is the possibility of devising suitable rapid separation schemes by a judicious choice of the different techniques available.
Author: F. Svec
Publisher: Elsevier
ISBN: 0080536972
Category : Science
Languages : en
Pages : 800
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Book Description
During the past decade, monolithic materials in the shape of discs, stacked layers, rolled sheets, sponges, irregular chunks, tubes, and cylinders have all been successfully demonstrated. These formats were prepared from a wide variety of materials including natural polymers such as cellulose, synthetic polymers that involved porous styrene-, methacrylate-, and acrylamide-based polymers, and inorganic materials, mainly silica. Each approach is interesting from the point of view of both preparation and application.Although the current papers and patents concerned with monolithic separation media are quite numerous, the information is scattered throughout a vast number of journals. This book therefore fills the gap in the market for a comprehensive reference book on this subject.Monolithic materials concerns all of the current formats of monolithic materials and provides an integrated view of this novel format of separation media. Since the flow pattern in monolithic devices is different from that in packed beds, the hydrodynamics of the system and mass transport differ considerably from those derived for packed columns. Therefore, this book presents contributions concerned with both flow and mass transfer in the monolithic materials. A significant proportion of the book is devoted to the applications of monolithic materials. It also provides the reader with valuable information about the sources of the specific materials, their properties, and potential applications. · Monolithic materials are currently very popular within several scientific areas such as chromatography, optics, catalysis, diagnostics, genomics, proteomics, and microfluidics.· Provides valuable information about the sources of the specific materials, their properties, and potential applications.· Chapters written by leading experts in the area.
Author: Michal Holcapek
Publisher: Elsevier
ISBN: 0128117338
Category : Technology & Engineering
Languages : en
Pages : 522
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Book Description
Handbook of Advanced Chromatography /Mass Spectrometry Techniques is a compendium of new and advanced analytical techniques that have been developed in recent years for analysis of all types of molecules in a variety of complex matrices, from foods to fuel to pharmaceuticals and more. Focusing on areas that are becoming widely used or growing rapidly, this is a comprehensive volume that describes both theoretical and practical aspects of advanced methods for analysis. Written by authors who have published the foundational works in the field, the chapters have an emphasis on lipids, but reach a broader audience by including advanced analytical techniques applied to a variety of fields. Handbook of Advanced Chromatography / Mass Spectrometry Techniques is the ideal reference for those just entering the analytical fields covered, but also for those experienced analysts who want a combination of an overview of the techniques plus specific and pragmatic details not often covered in journal reports. The authors provide, in one source, a synthesis of knowledge that is scattered across a multitude of literature articles. The combination of pragmatic hints and tips with theoretical concepts and demonstrated applications provides both breadth and depth to produce a valuable and enduring reference manual. It is well suited for advanced analytical instrumentation students as well as for analysts seeking additional knowledge or a deeper understanding of familiar techniques. Includes UHPLC, HILIC, nano-liquid chromatographic separations, two-dimensional LC-MS (LCxLC), multiple parallel MS, 2D-GC (GCxGC) methodologies for lipids analysis, and more Contains both practical and theoretical knowledge, providing core understanding for implementing modern chromatographic and mass spectrometric techniques Presents chapters on the most popular and fastest-growing new techniques being implemented in diverse areas of research
Author: A. Braithwaite
Publisher: Springer Science & Business Media
ISBN: 9401105995
Category : Science
Languages : en
Pages : 573
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Book Description
This book provides a unified and balanced introduction to the general theory of chromatography, followed by a detailed treatment of the principles and practice of all the major techniques currently employed in the industrial and academic sectors. It is written as a broad introduction to the subject for mid to advanced undergraduates in chemistry, pharmacy, biochemistry, and is suitable for students following the now quite numerous Masters degrees in instrumental analysis. The book has been updated to incorporate advances of the last ten years, and it contains around 50% new or revised material.
Author: Inamuddin
Publisher: Materials Research Forum LLC
ISBN: 1945291338
Category : Technology & Engineering
Languages : en
Pages : 311
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Book Description
The ion-exchange process is a natural phenomenon and mankind has been using this technique since the early days of civilisation. With the progress of technologies and concepts, we got a better understanding of this technique and increased its application horizon. Like in other research areas, nanotechnology has also penetrated heavily into this field, and has helped develop smart materials with better properties for application in adsorption and ion-exchange chromatography. A large amount of research was carried out in this field in the last few decades, showing the importance of these materials and technologies. Water treatment is receiving great attention worldwide, due to the increasing demand of drinking water and hence the need to recycle polluted water sources. Keeping this importance in mind, this book “Applications of Adsorption and Ion Exchange Chromatography in Waste Water Treatment” has been edited with contributions from well know experts in the field, who have been working on different ion-exchange materials and technologies for many years.
Author: Joel K. Swadesh
Publisher: CRC Press
ISBN: 1420042661
Category : Science
Languages : en
Pages : 480
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Book Description
Product specifications, regulatory constraints, and tight production schedules impose considerable pressures on separation scientists in industry. The first edition of HPLC: Practical and Industrial Applications helped eliminate the need for extensive library or laboratory research when confronting a problem, an unfamiliar technique, or work in a n
Author: Mustafa Ali Mohd
Publisher: BoD – Books on Demand
ISBN: 9535102982
Category : Science
Languages : en
Pages : 474
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Book Description
Progress in agricultural, biomedical and industrial applications' is a compilation of recent advances and developments in gas chromatography and its applications. The chapters cover various aspects of applications ranging from basic biological, biomedical applications to industrial applications. Book chapters analyze new developments in chromatographic columns, microextraction techniques, derivatisation techniques and pyrolysis techniques. The book also includes several aspects of basic chromatography techniques and is suitable for both young and advanced chromatographers. It includes some new developments in chromatography such as multidimensional chromatography, inverse chromatography and some discussions on two-dimensional chromatography. The topics covered include analysis of volatiles, toxicants, indoor air, petroleum hydrocarbons, organometallic compounds and natural products. The chapters were written by experts from various fields and clearly assisted by simple diagrams and tables. This book is highly recommended for chemists as well as non-chemists working in gas chromatography.
Author: Inamuddin
Publisher: Springer
ISBN: 3030060829
Category : Medical
Languages : en
Pages : 225
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Book Description
This book presents the applications of ion-exchange materials in the biomedical industries. It includes topics related to the application of ion exchange chromatography in determination, extraction and separation of various compounds such as amino acids, morphine, antibiotics, nucleotides, penicillin and many more. This title is a highly valuable source of knowledge on ion-exchange materials and their applications suitable for postgraduate students and researchers but also to industrial R&D specialists in chemistry, chemical, and biochemical technology. Additionally, this book will provide an in-depth knowledge of ion-exchange column and operations suitable for engineers and industrialists.
Author: František Švec
Publisher:
ISBN: 9780444508799
Category : Chromatographic analysis
Languages : en
Pages : 773
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Book Description
