Author: Laëtitia Salou
Publisher:
ISBN:
Category :
Languages : en
Pages : 212
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Book Description
Biocompatible and corrosion resistant regarding biological fluids, titanium is still an inert material: it does not participate actively at the tissue-integration around the implant. Surface modification of titanium at nanoscale can promote cell adhesion and differentiation by modulate genes expression due to a phenomenon of mechano-transduction. In this thesis, we have focused on the development, the characterization and the direct application of our nanostructured surface of medical devices. First of all, our study focused on the preparation and physicochemical characterization. After obtaining reproducible surfaces on small samples, our research has focused on the biological characterization of the surface. In-vivo studies conducted in rabbits have allowed us to show similar biomechanical attachment and good osseointegration of the nanostructured surface compared to commonly used surfaces on the market. The application of this new surface on more complex titanium implant such as tracheal prosthesis, has allowed us to observe delamination phenomenon of the nanostructure layer. Therefore, our research was oriented towards the problem of mechanical strength of the surface with the realization of nano scratch test and tribology. A topic in the zeitgeist, as a new EU regulation for medical devices which incorporate nanomaterials will take effect in 2017. To conclude, this work enable to propose a nanosurface with promising results of tissues integration required for medical device.
Author: Nina Adden
Publisher:
ISBN:
Category :
Languages : en
Pages : 130
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Book Description
Author: Yoshiki Oshida
Publisher: Elsevier
ISBN: 0080467199
Category : Technology & Engineering
Languages : en
Pages : 447
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Book Description
This unique book about bioscience and the bioengineering of titanium materials is based on more than 1,000 published articles. It bridges the gap between the medical/dental fields and the engineering/technology areas, due to the author's unique experience in both during the last 30 years. The book covers Materials Classifications, Chemical and Electrochemical Reactions, Oxidation, Biological Reactions, Implant-related Biological Reactions, Applications, Fabri-cation Technologies, Surface Modifications, and Future Perspectives.* Provides quick access to the primary literature in this field* Reviews studies of titanium materials in medical and dental applications, as reported in nearly 1,500 articles published over last several years* Draws information from several types of studies and reports* Helps readers answer questions about the most appropriate materials and when to use them
Author: D.M. Brunette
Publisher: Springer Science & Business Media
ISBN: 3642564860
Category : Technology & Engineering
Languages : en
Pages : 1019
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Book Description
Providing scientific and technical in-depth information in a clear format with a homogeneous structure, this text is suited for educational and self-teaching purposes as well as a reference on titanium for biomedical applications. It covers the whole area relevant to the use of titanium for implants, devices and instruments in medicine: material and surface science, physics, chemistry, biology, medicine, quality and regulatory aspects.
Author: Mariana Cruz
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Background: Calcium-phosphate bioactive coatings have been suggested to improve the biological response of titanium. We have developed a new manufacturing protocol that enables integration of these bioactive materials in a titanium scaffold, overcoming the mechanical limitations of coatings. However, the biological behavior of these new materials is not yet described. Objectives: The aim of this study was to evaluate the behavior of human fetal osteoblasts and human gingival fibroblasts in contact with Titanium (Ti), Ti with 5% hydroxyapatite (TiHA) or Ti with 5% beta tricalcium phosphate (Ti-bTCP). Materials and methods: Ti, TiHA and Ti-bTCP discs were produced with homogeneous surface roughness. Human fetal osteoblasts and human gingival fibroblasts were cultured on discs for 14 days using previously established methods. Morphology and cellular adhesion were analyzed using scanning electron microscopy (SEM) after 1 and 7 days. Cell viability and proliferation were evaluated at pre-defined time-points (1,3,7 and 14 days) using a commercial resazurin-based method. Alkaline phosphatase (ALP) activity was evaluated at 7 and 14 days for osteoblasts. All results were presented as mean fluorescence intensity (AU) u00b1 standard deviation (SD). Mineralization patterns were evaluated using hydroxyapatite fluorescence staining. Group comparisons were tested using Anova (Tukeyu2019s post-hoc) using appropriate statistical software and significance was set p
Author: Farah Nabeel Mohammed Tahir Al-Khayyat
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Karan Gulati
Publisher: Springer Nature
ISBN: 3031215656
Category : Technology & Engineering
Languages : en
Pages : 259
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Book Description
This book provides a comprehensive technical and scientific overview of the surface modification of titanium dental implants. Coverage ranges from basic concepts of surface modification to advanced micro- and nano-engineering strategies employed to achieve augmented bioactivity to meet the needs of compromised patient conditions. A special focus of the book is advanced state-of-the-art electrochemically anodized nanostructures fabricated on implants towards enhanced bioactivity and local therapy. Surface Modification of Titanium Dental Implants will keep you current in the domain of titanium dental implants and will provide an improved understanding of their performance and application. The book will benefit engineers, clinicians, and researchers in biomaterials, biomedical engineering, dental and bone implants, nano-engineering, and technology.
Author: Jan Sieniawski
Publisher: BoD – Books on Demand
ISBN: 9535111108
Category : Technology & Engineering
Languages : en
Pages : 160
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Book Description
The book contains six chapters and covers topics dealing with biomedical applications of titanium alloys, surface treatment, relationships between microstructure and mechanical and technological properties, and the effect of radiation on the structure of the titanium alloys.
Author: Hao Zhang
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Abstract:Titanium surfaces have been constantly modified to improve bioactivity and osseointegration. In this study, we modified titanium surfaces through hydrothermal treatment with a mixed solution of phytic acid and calcium hydroxide, then evaluated their bioactive and osteogenic activities. In vitro tests, calcium-decorated titanium surface enhanced the cell adhesion, proliferation and osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs). In vivo tests, Micro- CT and histological evaluations indicated that the modified implants promoted new bone formation and osseointegration between the implants and the host bone. These findings provided evidence that this simple modification would be promising solution to improve bioactivity and osseointegration, which would be beneficial not only for titanium implants but also other implanted biomaterials.Background: Titanium (Ti) or titanium alloys coated with various bioactive calcium phosphates (CaPs), including hydroxyapatite (HA) and u03b2-tricalcium phosphate (u03b2-TCP), are considered as satisfactory implant materials. CaP coatings provide nanostructural or microstructuctural characteristics on titanium or titanium alloys, thereby increasing the adhesion of osteoblasts, which enhance the osseointegration and shorten the healing time.Aim: To prepare and evaluate the effect of calcium-containing chemical conversion coating on promoting new bone formation and early osseointegration in vivo.Material and methods: We designed and prepared a phytic acid/calcium hydroxide composite coating on the pure titanium implant (Ti-SLA-2/10) through hydrothermal treatment with a mixed solution of phytic acid (PA) and saturated calcium hydroxide solution [Ca (OH)2]. The pure titanium implant with a sandblasted/acid-etched (SLA) surface was used as the control group (Ti-SLA). The surface morphology, elemental composition, surface roughness, wettability, and calcium ion release were investigated separately. Twenty-four SLA and calcium-containing SLA implants were immediately inserted into the mandibles of twelve New Zealand white rabbits. The biological effects were evaluated by Micro-computed tomography (Micro-CT) analysis and histological evaluation after 1, 2, and 4 weeks of healing. Results: Phytic acid/calcium hydroxide composite coating with superior hydrophilicity were successfully prepared on titanium implants. The surface characteristics showed Ti-SLA-2/10 implants with multiple pits and craters can release calcium ions continuously. In vivo, the volume of new bone around the Ti-SLA-2/10 implants was significantly higher than that of the Ti-SLA implants, but more fibrous tissue was observed surround the Ti-SLA implants after 1 week of healing. The Ti-SLA-2/10 implants showed higher bone volume fraction (bone volume/total volume, BV/TV, %) than that of the Ti-SLA implants at each time points (p
Author: Alessandro Rozim Zorzi
Publisher: BoD – Books on Demand
ISBN: 9535125389
Category : Medical
Languages : en
Pages : 388
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Book Description
Advanced Techniques in Bone Regeneration is a book that brings together over 15 chapters, written by leading practitioners and researchers, of the latest advances in the area, including surgical techniques, new discoveries, and promising methods involving biomaterials and tissue engineering. This book is intended for all who work in the treatment of disorders involving problems with the regeneration of bone tissue, are doctors or dentists, as well as are researchers and teachers involved in this exciting field of scientific knowledge.
