Manganese in Health and Disease

Manganese in Health and Disease PDF Author: Lucio G Costa
Publisher: Royal Society of Chemistry
ISBN: 1782622381
Category : Medical
Languages : en
Pages : 655

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Book Description
Manganese in the diet is nutritionally essential for normal physiologic functioning. However, excessive exposure to manganese has been associated with developmental, neurodegenerative and other disorders. The book comprehensively covers the toxicology of manganese. Leading investigators provide perspectives from toxicology, neuroscience, nutrition, molecular biology and risk assessment disciplines and chapters cover the toxicokinetics, toxicodynamic interactions and health effects of manganese, as well as its potential role in neurodegenerative diseases. A large section devoted to health effects presents the latest research that associates manganese exposure to potential human diseases. Any scientists, health professional or regulator involved with metal exposure and toxicology should find this volume essential reading. Students and researchers in neurotoxicology will also find this book a useful reference.

Toxicological Profile for Manganese

Toxicological Profile for Manganese PDF Author:
Publisher:
ISBN:
Category : Manganese
Languages : en
Pages : 236

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Book Description


Toxicological Profile for Manganese and Compounds

Toxicological Profile for Manganese and Compounds PDF Author: Life Systems, Inc
Publisher:
ISBN:
Category : Manganese
Languages : en
Pages : 164

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Book Description


Mineral and Metal Neurotoxicology

Mineral and Metal Neurotoxicology PDF Author: Masayuki Yasui
Publisher: CRC Press
ISBN: 1439810699
Category : Medical
Languages : en
Pages : 481

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Book Description
Trace minerals and metals such as zinc, copper, and magnesium are accepted as a "natural" part of the human system. Interactions of some elements and/or disturbances in trace-metal or mineral homeostasis can, however, be toxic to the central nervous system (CNS). Mineral and Metal Neurotoxicology describes a wide range of basic and clinical issues

Manganese in Health and Disease

Manganese in Health and Disease PDF Author: Lucio G Costa
Publisher: Royal Society of Chemistry
ISBN: 1849739439
Category : Medical
Languages : en
Pages : 654

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Book Description
Manganese in the diet is nutritionally essential for normal physiologic functioning. However, excessive exposure to manganese has been associated with developmental, neurodegenerative and other disorders. The book comprehensively covers the toxicology of manganese. Leading investigators provide perspectives from toxicology, neuroscience, nutrition, molecular biology and risk assessment disciplines and chapters cover the toxicokinetics, toxicodynamic interactions and health effects of manganese, as well as its potential role in neurodegenerative diseases. A large section devoted to health effects presents the latest research that associates manganese exposure to potential human diseases. Any scientists, health professional or regulator involved with metal exposure and toxicology should find this volume essential reading. Students and researchers in neurotoxicology will also find this book a useful reference.

Toxicological Profile for Manganese

Toxicological Profile for Manganese PDF Author:
Publisher:
ISBN:
Category : Manganese
Languages : en
Pages : 510

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Book Description


Neurotoxicology of Manganese

Neurotoxicology of Manganese PDF Author: John Donaldson
Publisher:
ISBN:
Category : Manganese
Languages : en
Pages : 136

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Book Description


Manganese and Its Compounds

Manganese and Its Compounds PDF Author: Paul Howe
Publisher: World Health Organization
ISBN: 9241530634
Category : Health & Fitness
Languages : en
Pages : 71

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Book Description
On cover: IPCS International Programme on Chemical Safety. Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization and the World Health Organization, and produced within the framework of the Inter-organization Programme for the Sound Management of Chemicals (IOMC)

Neurotoxicity of Neonatal Manganese Exposure

Neurotoxicity of Neonatal Manganese Exposure PDF Author: Cynthia H. Kern
Publisher:
ISBN:
Category :
Languages : en
Pages : 312

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Book Description


Toxicological Profile for Manganese

Toxicological Profile for Manganese PDF Author: U.s. Department of Health and Human Services
Publisher: Createspace Independent Publishing Platform
ISBN: 9781495287374
Category : Medical
Languages : en
Pages : 556

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Book Description
This toxicological profile is prepared in accordance with guidelines developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). The original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised and republished as necessary. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the toxic substances each profile describes. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicologic properties. Other pertinent literature is also presented but is described in less detail than the key studies. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The profiles focus on health and toxicologic information; therefore, each toxicological profile begins with a public health statement that describes, in nontechnical language, a substance's relevant toxicological properties. Following the public health statement is information concerning levels of significant human exposure and, where known, significant health effects. A health effects summary describes the adequacy of information to determine a substance's health effects. ATSDR identifies data needs that are significant to protection of public health. Each profile: (A) Examines, summarizes, and interprets available toxicologic information and epidemiologic evaluations on a toxic substance to ascertain the levels of significant human exposure for the substance and the associated acute, subacute, and chronic health effects; (B) Determines whether adequate information on the health effects of each substance is available or being developed to determine levels of exposure that present a significant risk to human health of acute, subacute, and chronic health effects; and (C) Where appropriate, identifies toxicologic testing needed to identify the types or levels of exposure that may present significant risk of adverse health effects in humans.

Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic

Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic PDF Author: Peggy L. Carver
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110526980
Category : Science
Languages : en
Pages : 640

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Book Description
Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.