Neuromodulation for pharmacoresistant epilepsy: From bench to bed

Neuromodulation for pharmacoresistant epilepsy: From bench to bed PDF Author: Tianfu Li
Publisher: Frontiers Media SA
ISBN: 2832545580
Category : Medical
Languages : en
Pages : 92

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Book Description

Neuromodulation for pharmacoresistant epilepsy: From bench to bed

Neuromodulation for pharmacoresistant epilepsy: From bench to bed PDF Author: Tianfu Li
Publisher: Frontiers Media SA
ISBN: 2832545580
Category : Medical
Languages : en
Pages : 92

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Book Description


Pharmacoresistance in Epilepsy

Pharmacoresistance in Epilepsy PDF Author: Luisa Rocha
Publisher: Springer Science & Business Media
ISBN: 1461464641
Category : Medical
Languages : en
Pages : 333

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Book Description
Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoesistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they’re studying epilepsy in the lab or treating it in a doctor’s office.”

Electroconvulsive and Neuromodulation Therapies

Electroconvulsive and Neuromodulation Therapies PDF Author: Conrad M. Swartz
Publisher: Cambridge University Press
ISBN: 1139478869
Category : Medical
Languages : en
Pages : 619

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Book Description
Electroconvulsive therapy (ECT) is a psychiatric treatment involving the induction of a seizure through the transmission of electricity in the brain. Because of exploitation movies and greatly heightened drug company promotional activities ECT was used less frequently in the 1980s and 1990s. Eventually these movies were understood as unrealistic. Now these drugs are increasingly recognized as dangers to body health. Because of recent refinements and a far better scientific understanding of the clinical procedures and mechanisms underpinning ECT, this treatment modality has seen a resurgence in use and widespread appreciation of its safety. This book is the new definitive reference on electroconvulsive and neuromodulation therapies. It comprehensively covers the scientific basis and clinical practice of ECT as well as comparisons between ECT and medication therapies including the new generation of antipsychotic drugs. It also provides readers with administrative perspectives and specific details for the management of this modality in clinical practice. The new forms of nonconvulsive electrical and magnetic brain stimulation therapy are also covered in detail, in a separate section. The chapter authors are leading scholars and clinicians.

Translational Neuroimmunology, Volume 7

Translational Neuroimmunology, Volume 7 PDF Author: Nima Rezaei
Publisher: Elsevier
ISBN: 0323900712
Category : Medical
Languages : en
Pages : 542

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Book Description
Translational NeuroImmunology: Neuroinflammation updates on bench to bedside studies on neurological disorders that have immunological etiologies. The book covers neuroimmunology and the principles of autoimmune and autoinflammatory neurological disorders, with multiple sclerosis as the main focus. The immunopathology, genetics and epigenetics, microbiome, diagnosis and treatment of multiple sclerosis will be explained in ten chapters. A chapter also examines distinct aspects of pericytes, with final discussions on the neurologic manifestations, diagnostic approaches and treatments of the various neuroimmune disorders and lessons learned from translational research on non-human primates and zebrafish. All sections are presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research. Gives an introduction on neuroimmunological diseases, from bench to bedside Encourages the development of immunologic approaches to analyze the interaction and specific properties of nervous tissue elements during development and disease Focuses on understanding and therapeutically manipulating immunological responses to injury, degeneration and autoimmunity in the central nervous system Proves changes in relevant immune and inflammatory reactions at the cellular and molecular level during the development of nervous system diseases

Acupuncture Therapy for Neurological Diseases

Acupuncture Therapy for Neurological Diseases PDF Author: Ying Xia
Publisher: Springer Science & Business Media
ISBN: 3642108571
Category : Medical
Languages : en
Pages : 490

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Book Description
Acupuncture therapy has been practiced in China and other Asian countries for more than two thousand years. Modern clinical research has confirmed the impressive therapeutic effect of acupuncture on numerous human ailments, such as controlling pain, nausea, and vomiting. However, the biological mechanisms of acupuncture are still under debate. In Traditional Chinese Medicine (TCM), the mechanism of acupuncture therapy is explained by a meridian model. According to this model, acupuncture is believed to treat the diseased organs by modulating two conditions known as Yin and Yang, which represent all the opposite principles that people find in the universe, both inside and outside the human body. Yin and Yang complement each other, and are subjected to changes between each other. The balance of Yin and Yang is thought to be maintained by Qi, an energy substance flowing constantly through the meridian, a network connecting all the organs of the body. The illness, according to this theory, is the temporary dominance of one principle over the other, owing to the blockade of the Qi from flowing through the meridian under certain circumstance. The axiom of “No stagnation, No pain” in TCM summarizes this concept. Thus, the goal of acupuncture treatment is to restore the balance of Yin and Yang conditions in the diseased organ(s). This theory has been considered to be useful to guide this ancient therapy, such as carrying out diagnosis, deciding on the principle, and selecting the acupoints.

Issues in Clinical Epileptology: A View from the Bench

Issues in Clinical Epileptology: A View from the Bench PDF Author: Helen E. Scharfman
Publisher: Springer
ISBN: 9789402407891
Category : Medical
Languages : en
Pages : 0

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Book Description
This book is dedicated to Dr. Philip A. Schwartzkroin. The book has a novel format because it is not intended to be a set of reviews. Instead, it is an effort to explore important topics in the epilepsy research field. Because articles are written by leaders in the field who have years of experience and individuals with diverse expertise, articles are likely to have a long-lasting impact and be relevant for both epileptologists and neuroscientists. Authors address topics that are important, unresolved questions in the field of epilepsy research, drawing on available data from both the bench and the clinic to support their points. A given topic is addressed by one or more authors, each writing from his/her own unique perspective. For all of the individuals who have been trained or worked with Philip Schwartzkroin in the past and/or have appreciated his contributions to the epilepsy field, this volume is an excellent way to celebrate his achievements and look to the ways they have moved the field forward and continue to stimulate its growth.

Sudden Unexpected Death in Epilepsy

Sudden Unexpected Death in Epilepsy PDF Author: Claire M. Lathers
Publisher: CRC Press
ISBN: 1482223880
Category : Law
Languages : en
Pages : 348

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Book Description
Sudden Unexpected Death in Epilepsy: Mechanisms and New Methods for Analyzing Risks builds on earlier works focusing on the clinical problem of sudden unexpected death in epilepsy (SUDEP). This book presents a methodology for identifying and classifying clusters of risks that lead to SUDEP. Developed over the last two years, the SUDEP Classificatio

Oxford Textbook of Epilepsy and Epileptic Seizures

Oxford Textbook of Epilepsy and Epileptic Seizures PDF Author: Samden Lhatoo
Publisher: Oxford University Press, USA
ISBN: 0199659044
Category : Medical
Languages : en
Pages : 395

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Book Description
Part of the Oxford Textbooks in Clinical Neurology (OTCN) series, this volume covers the scientific basis, clinical diagnosis, and treatment of epilepsy and epileptic seizures, and is complemented by an online edition.

Relieving Pain in America

Relieving Pain in America PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 030921484X
Category : Medical
Languages : en
Pages : 383

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Book Description
Chronic pain costs the nation up to $635 billion each year in medical treatment and lost productivity. The 2010 Patient Protection and Affordable Care Act required the Department of Health and Human Services (HHS) to enlist the Institute of Medicine (IOM) in examining pain as a public health problem. In this report, the IOM offers a blueprint for action in transforming prevention, care, education, and research, with the goal of providing relief for people with pain in America. To reach the vast multitude of people with various types of pain, the nation must adopt a population-level prevention and management strategy. The IOM recommends that HHS develop a comprehensive plan with specific goals, actions, and timeframes. Better data are needed to help shape efforts, especially on the groups of people currently underdiagnosed and undertreated, and the IOM encourages federal and state agencies and private organizations to accelerate the collection of data on pain incidence, prevalence, and treatments. Because pain varies from patient to patient, healthcare providers should increasingly aim at tailoring pain care to each person's experience, and self-management of pain should be promoted. In addition, because there are major gaps in knowledge about pain across health care and society alike, the IOM recommends that federal agencies and other stakeholders redesign education programs to bridge these gaps. Pain is a major driver for visits to physicians, a major reason for taking medications, a major cause of disability, and a key factor in quality of life and productivity. Given the burden of pain in human lives, dollars, and social consequences, relieving pain should be a national priority.

The Clinical Neurophysiology Primer

The Clinical Neurophysiology Primer PDF Author: Andrew S. Blum
Publisher: Springer Science & Business Media
ISBN: 1597452718
Category : Medical
Languages : en
Pages : 515

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Book Description
This book presents a broad yet focused treatment of central topics in the field of clinical neurophysiology. The volume was inspired by the clinical neurophysiology lecture series at Beth Israel-Deaconess Medical Center and Rhode Island Hospital. Much like the lecture series, this book is designed to acquaint trainees with the essential elements of clinical neurophysiology. Each chapter is written by leading and respected clinical neurophysiologists.