Neurobiology of Central D1-Dopamine Receptors PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Neurobiology of Central D1-Dopamine Receptors PDF full book. Access full book title Neurobiology of Central D1-Dopamine Receptors by George Breese. Download full books in PDF and EPUB format.
Author: George Breese
Publisher: Springer Science & Business Media
ISBN: 146845191X
Category : Medical
Languages : en
Pages : 223
Get Book Here
Book Description
Our understanding of the functional mechanisms relating dopamine activity to normal and abnormal behavior has been turned "upside-down" by the recent developments described in the chapters of this volume. Heretofore, it was generally agreed that all of the pharmacological and behavioral properties ascribed to dopamine systems were mediated via activation or inhibition of the subtype of dopamine receptors termed D2. The properties of these receptors were first characterized in 1975 following their identification by receptor binding techniques utilizing 3H-butyrophenones, potent antipsychotic drugs, used in the treatment of schizophrenia. Although another subtype of dopamine receptor had already been identified a few years earlier, now termed the Dl receptor, its functional properties were unknow- other than the fact that it was associated with the activation of the enzyme adenylate cyclase. Our absence of knowledge of the behavioral functions of this receptor stemmed primarily from the lack of selective agonist and antagonists for DI receptors - drugs which did not also interact with D2 receptors. Selective agents for D2 receptors did exist and hence the behavioral roles of D2 receptors were easily ascribed. The work described in this text is primarily stimulated by the development of two selective Dl receptor drugs - the antagonist SCH 23390 and the agonist SKF 38393. The studies described herein clearly show that D1 receptors do indeed have many behavioral functions, on the surface often similar to those responses mediated by D2 receptors.
Author: George Breese
Publisher: Springer Science & Business Media
ISBN: 146845191X
Category : Medical
Languages : en
Pages : 223
Get Book Here
Book Description
Our understanding of the functional mechanisms relating dopamine activity to normal and abnormal behavior has been turned "upside-down" by the recent developments described in the chapters of this volume. Heretofore, it was generally agreed that all of the pharmacological and behavioral properties ascribed to dopamine systems were mediated via activation or inhibition of the subtype of dopamine receptors termed D2. The properties of these receptors were first characterized in 1975 following their identification by receptor binding techniques utilizing 3H-butyrophenones, potent antipsychotic drugs, used in the treatment of schizophrenia. Although another subtype of dopamine receptor had already been identified a few years earlier, now termed the Dl receptor, its functional properties were unknow- other than the fact that it was associated with the activation of the enzyme adenylate cyclase. Our absence of knowledge of the behavioral functions of this receptor stemmed primarily from the lack of selective agonist and antagonists for DI receptors - drugs which did not also interact with D2 receptors. Selective agents for D2 receptors did exist and hence the behavioral roles of D2 receptors were easily ascribed. The work described in this text is primarily stimulated by the development of two selective Dl receptor drugs - the antagonist SCH 23390 and the agonist SKF 38393. The studies described herein clearly show that D1 receptors do indeed have many behavioral functions, on the surface often similar to those responses mediated by D2 receptors.
Author: George Breese
Publisher:
ISBN: 9781468451924
Category :
Languages : en
Pages : 228
Get Book Here
Book Description
Author: M. J. Goldstein
Publisher: Springer
ISBN: 1489927239
Category : Science
Languages : en
Pages : 184
Get Book Here
Book Description
The development of a selective D1 dopamine (DA) receptor antagonist SCH 23390 stimulated a number of studies on the functions mediated by central DA receptor subtypes. It was generally assumed that the central D1 DA receptor isa molecular entity whose function awaits further discovery. The papers presented in this volume clearly show that this is no longer the case and that D1 DA receptors have many behavioral fuctions which might be altered in pathological states. A number of papers have recognized the interdependence of the regulatory functions of the D1 DA receptors with D2 and other receptor proteins, and vice versa. The biochemical, pharmacological and morphological characterization of the D1 and D2 DA receptor binding proteins, as well as of DARPP-32, illustrates the complex interactions between various macromolecules. Procedures described for the purification of the D1 and D2 DA receptor subtypes are fundamental for future studies on the mechanisms involved in the coupling of the receptor proteins with signal transducing systems. Several studies in this volume show that D1 DA receptors have behavioral functions and that they are often similar to the responses mediated by D2 DA receptors, but in some instances reflect divergent neuronal activity of both systems. The knowledge of the physiology and biochemistry of the central DA receptor subtypes could lead to the development of a new generation of drugs which ameliorate some mental and neurological dysfunctions without producing severe undesirable side effects.
Author:
Publisher: ScholarlyEditions
ISBN: 1481609858
Category : Medical
Languages : en
Pages : 74
Get Book Here
Book Description
Dopamine Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Dopamine Receptors in a concise format. The editors have built Dopamine Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Dopamine Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Dopamine Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: P.F. Spano
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 304
Get Book Here
Book Description
Author:
Publisher: ScholarlyEditions
ISBN: 1481675117
Category : Medical
Languages : en
Pages : 73
Get Book Here
Book Description
Dopamine Receptors—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Dopamine D1 Receptors in a concise format. The editors have built Dopamine Receptors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Dopamine D1 Receptors in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Dopamine Receptors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author:
Publisher: Elsevier
ISBN: 0444634274
Category : Science
Languages : en
Pages : 320
Get Book Here
Book Description
Progress in Brain Research is a well-established international series examining major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume, concentrates on state-of-the-art of dopamine research: from basic science to clinical applications. It covers topics including thalamostriatal synapses as a substrate for dopamine action; the multilingual nature of dopamine neurons; ethanol-mechanisms along the mesolimbic dopamine system, and much more.Progress in Brain Research is the most acclaimed and accomplished series in neuroscience, firmly established as an extensive documentation of the advances in contemporary brain research. The volumes, some of which are derived from important international symposia, contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry, and the behavioral sciences. The most acclaimed and accomplished series in neuroscience This volume looks at dopamine research in the light of the newest scholarly discoveries and insights
Author: Peter Jenner
Publisher: IOS Press
ISBN: 9789051992915
Category : Dopamine
Languages : en
Pages : 200
Get Book Here
Book Description
Multiple subtypes of dopamine receptors exist in the brain. This volume reviews the characteristics of D-1, D-2, D-3 and D-4 receptors and describes the current concepts of their involvement in motor disorders and in the control of schizophrenia. Readers: the book will be of great interest to professionals in pharmacology, medicinal chemistry, neuroscience, cell biology and therapeutic applications in clinical medicine as antipsychotics, anti-Parkinson's disease and related areas.
Author:
Publisher: ScholarlyEditions
ISBN: 1464941556
Category : Medical
Languages : en
Pages : 46
Get Book Here
Book Description
Dopamine Receptors: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Dopamine Receptors in a concise format. The editors have built Dopamine Receptors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Dopamine Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Dopamine Receptors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Kim Neve
Publisher: Springer Science & Business Media
ISBN: 1603273336
Category : Medical
Languages : en
Pages : 650
Get Book Here
Book Description
As sites of action for drugs used to treat schizophrenia and Parkinson’s disease, dopamine receptors are among the most validated drug targets for neuropsychiatric disorders. Dopamine receptors are also drug targets or potential targets for other disorders such as substance abuse, depression, Tourette’s syndrome, and attention deficit hyperactivity disorder. Updated from the successful first edition, "The Dopamine Receptors" serves as a reference work on dopamine receptors while also highlighting the areas of research that are most active today. To achieve this goal, authors have written chapters that set a broad area of research in its historical context, rather than focusing on the research output of their own laboratories.