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Author: Jean-Paul Fillastre
Publisher: Presses universitaires de Rouen et du Havre
ISBN: 9782877756334
Category : Political Science
Languages : en
Pages : 346
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Book Description
L'utilisation d'antibiotiques contenant notamment des aminoglycosides pour com¬battre les affections bactériennes, est très répandue. Or, à long terme, elle pose sou¬vent des complications dont la néphrotoxicité est la plus fréquente. Si les manifes¬tations de ces complications rénales sont connues, les mécanismes de ces altérations le sont moins. Ces communications apportent donc des éclaircissements sur ces mécanismes et les effets de ces substances dans les néphrons, le transport et la pénétration dans les cellules labyrinthiques du rein, l'influence sur la structure cellulaire, les effets au niveau de l'appareil de Colgi et notamment les réactions des organites intracellulaires : lysosomes-mitochendria.
Author: Jean-Paul Fillastre
Publisher: Presses universitaires de Rouen et du Havre
ISBN: 9782877756334
Category : Political Science
Languages : en
Pages : 346
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Book Description
L'utilisation d'antibiotiques contenant notamment des aminoglycosides pour com¬battre les affections bactériennes, est très répandue. Or, à long terme, elle pose sou¬vent des complications dont la néphrotoxicité est la plus fréquente. Si les manifes¬tations de ces complications rénales sont connues, les mécanismes de ces altérations le sont moins. Ces communications apportent donc des éclaircissements sur ces mécanismes et les effets de ces substances dans les néphrons, le transport et la pénétration dans les cellules labyrinthiques du rein, l'influence sur la structure cellulaire, les effets au niveau de l'appareil de Colgi et notamment les réactions des organites intracellulaires : lysosomes-mitochendria.
Author: Peter Bach
Publisher: Springer Science & Business Media
ISBN: 1475720408
Category : Medical
Languages : en
Pages : 737
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Book Description
There has been a growing awareness that nephrotoxicity represents a key factor in human nephropathies, where, irrespective of the causative agent, only a few clinical end-effects are diagnosed. Thus nephropathies are generally classified as acute or chronic renal failure, malignancies or immunological changes. The weaknesses in diagnosing nephropathies arises because of the effective role the kidney plays in maintaining homeostasis, despite the fact that it has been extensively damaged. The frequencies of some type of chemically-induced acute renal failure is well documented, but the causes of chronic renal failure, malignancy, and other nephropathies are far more difficult to associate with a chemical aetiology. Many of the new therapeutic agents have important beneficial effects, but they are found to have marked nephrotoxic effects. Thus there is a growing urgency to increase the stringency of chemical safety evaluation for their potential nephrotoxic effects. This is strongly countered by the increased financial pressure to identify potentially nephrotoxic chemicals earlier in their development and humanitarian considerations to more closely relate animal test to the clinical situation. Part of the challenge may be achieved by the increasing use of in vitro techniques.
Author: J. Strauss
Publisher: Springer Science & Business Media
ISBN: 1461326370
Category : Medical
Languages : en
Pages : 327
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Book Description
This is the 11th of the Pediatric Nephrology series created to help us be in touch with developments which are relevant to the problems we face daily in clinical practice and the questions we ask and try to answer in clinical and experimental research. Like volume IX, this one focuses on one of the subgroups to which we are committed--the neonates' special fluid and electrolyte requirements. This volume has more on blood pressure and renal function and looks at the hormonal regulators. There is greater depth about intoxications and nephrotic agents, congenital disorders and mineral metabolism. The exchanges were stimulating and the controversies were brought out without need of much of my usual prodding. At Julie Ingelfinger's suggestion, at the end of each panel discussion I have added a comment to highlight the main points as I see them. Otherwise, the format remains as in past editions: the papers given related to the four major topic areas, each followed by panel and registrant discussion. Although the transcription is almost verbatim, you will not find the names of the discussants, purposely omitted to ease my editorial work and to encourage everyone to speak candidly. Some of the questions and answers are those submitted to the panelists after the sessions, incorporated here by request. Also, frequent references are made to others' work but their names have been omitted.
Author: P.H. Bach
Publisher: Springer Science & Business Media
ISBN: 9400933711
Category : Medical
Languages : en
Pages : 448
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Book Description
Author: Marc E. de Broe
Publisher: Springer Science & Business Media
ISBN: 1402025866
Category : Medical
Languages : en
Pages : 719
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Book Description
To you the reader, the joy of discovery begins, for We continue in our goal of providing a text which us the job is done. In this edition, we have corrected is useful, not only to the clinician, but of equal interest past deficiencies, added new topics, expanded infor- to the investigator. The selection of content has been mation regarding the pediatric age group, provided directed at topics of current interest rather than those up to date (March 2003) references, while remaining of historic contribution. We have stressed the cont- true to our concept of a multi-national author book. bution of cell biology and pathophysiology, were it We continue to believe that scientific information is an exists, believing it provides both a better understa- international commodity whose interpretation and ap- ing of toxic injury when known, and a rational dir- plication are strongly influenced by both the cultural tion for therapy and prevention. and ethnic background of the observer. The oppor- nity to share in the rich diversity of the international We are encouraged by the accumulation of rec- scientific community remains a fundamental goal of nized risk factors, which allow pre-treatment strati- this endeavor. To participate as equals leads to mu- cation of our patients’ relative risk and allow us to - tual respect and peer appreciation. The sharing of in- cus our preventative techniques on the individuals tellectual resources fostered by this effort should and most likely to gain the greatest benefit.
Author: Helmut G. Rennke
Publisher:
ISBN: 9781451173383
Category : Medical
Languages : en
Pages : 380
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Book Description
This text offers medical students a case-based approach to learning the mechanisms of renal disease. Each chapter covers a disease, beginning with a patient case and followed by a discussion of the pathophysiology of the disease. Issues of differential diagnosis and therapy are linked to pathophysiologic mechanisms. Short questions interspersed throughout the text require students to apply their knowledge. Detailed answers to the questions are included. New to this edition: Full-color artwork and design New color photomicrographs of clinical conditions Additional end-of-chapter summaries Up-to-date information based on new medical findings
Author: James E. Tisdale
Publisher: ASHP
ISBN: 1585282057
Category : Medical
Languages : en
Pages : 1134
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Book Description
Since the first edition of this book was published in 2005, drug therapy has seen both breakthrough advances and sobering setbacks. The changes will continue. That's why every health care professional, hospital and health system, pharmacy, and medical school needs this invaluable reference. It will help you detect, prevent and manage drug-related diseases. And also remind you to always ask yourself the increasingly critical question: "Could this disease be drug-related?"
Author: Olavi Pelkonen
Publisher: Springer
ISBN: 3319438069
Category : Medical
Languages : en
Pages : 485
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Book Description
This volume provides a comprehensive overview of the hazards inherent in herbal medicinal products, with systematic coverage of major toxicities. Topics include composition and quality control, toxicokinetics, interactions, safety pharmacology, approaches to studying complex mixtures including metabolomics and systems network pharmacology, and long-term toxicity. The volume also discusses various organ toxicities with a special emphasis on basic mechanisms of actions and the multicomponent and multi-target nature of herbal products. It concludes with a look to future challenges and opportunities. With contributions from noted experts, Toxicology of Herbal Products is a necessary resource for physicians, pharmacists, and toxicologists interested in complex plant-derived products.
Author: G.B. Silva Junior
Publisher: Karger Medical and Scientific Publishers
ISBN: 331806937X
Category : Medical
Languages : en
Pages : 369
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Book Description
Nephrology is one of the fastest growing specialties in medicine. Nevertheless, kidney disease is one of the most serious unmet health needs in many countries. To provide healthcare access with the desirable equity worldwide, the nephrology community needs to discuss this public health issue and take part in decisions for elaboration of public health policies with more justice and equity. This book brings together key current public health problems that affect kidney function and illuminates them in contributions by an international group of nephrologists and general practitioners. The chapters review current knowledge and provide guidelines to manage these conditions and decrease the disease burden. At the end, developments in the digital era and their application to kidney disease treatment are synthesized, and a broader outlook on the future of nephrology is given. Ultimately, the publication aims to gather nephrology and public health expertise from researchers from all over the world, providing a broad vision of issues that must be discussed and overcome to guarantee a better treatment for patients with kidney diseases in the world today.
Author: Jerry B. Hook
Publisher: CRC Press
ISBN: 9780881678857
Category : Medical
Languages : en
Pages : 588
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Book Description
This second edition provides a synthesis of recent research on the mechanisms of chemically-induced kidney injury. The text includes a review of current concepts of clinical nephrotoxicity and renal failure, and mechanisms of specific classes of nephrotoxic drugs and environmental chemicals.
