Natural Products as Sources of Innovative Approaches in Psychiatry PDF Download
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Author: Elaine Elisabetsky
Publisher: Frontiers Media SA
ISBN: 2889768619
Category : Medical
Languages : en
Pages : 158
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Book Description
Author: Elaine Elisabetsky
Publisher: Frontiers Media SA
ISBN: 2889768619
Category : Medical
Languages : en
Pages : 158
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Book Description
Author: Valdir Cechinel Filho
Publisher: Springer
ISBN: 3030005453
Category : Science
Languages : en
Pages : 531
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Book Description
This book addresses the highly relevant and complex subject of research on drugs from natural products, discussing the current hot topics in the field. It also provides a detailed overview of the strategies used to research and develop these drugs. Respected experts explore issues involved in the production chain and when looking for new medicinal agents, including aspects such as therapeutic potential, functional foods, ethnopharmacology, metabolomics, virtual screening and regulatory scenarios. Further, the book describes strategic methods of isolation and characterization of active principles, biological assays, biotechnology of plants, synthesis, clinical trials and the use of tools to identity active principles.
Author: Ipek Suntar
Publisher: Bentham Science Publishers
ISBN: 981512305X
Category : Science
Languages : en
Pages : 314
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Book Description
Natural products have dominated our lives since ancient times. Today, they are an inexhaustible source of new medications for disease treatment. The practice of evaluating bioactive compounds extracted from natural sources has also advanced significantly, prompting a need to understand current methods to identify and evaluate them. This book covers basic scientific aspects of preclinical research on natural products for specific conditions and diseases. These include aging, gynecological disorders, inflammatory disorders, renal disorders and cardiovascular disorders. Each of the 10 book chapters give a structured overview on preclinical methods on the etiology of diseases, natural products as the materials for the bioassays, extract types, concentration of the extracts/compounds for in vitro and in vivo assays, preparation of the test materials, application of the test materials, step-by-step methods and related calculations. The book is intended as a quick reference for natural product researchers, pharmacists and postgraduate students in pharmacognosy. Medical doctors working in preclinical research on natural products will also benefit from the information provided.
Author: Subhash C. Mandal
Publisher: Elsevier
ISBN: 0081021046
Category : Science
Languages : en
Pages : 776
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Book Description
Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout
Author: Takeshi Ogura
Publisher: CRC Press
ISBN: 9789057022098
Category : Science
Languages : en
Pages : 688
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Book Description
Preface: Natural products chemistry has a long history, and could be regarded as having its roots in the use of many kinds of herbal mixtures as crude drugs in traditional medicine. Systems of traditional medicine have been practiced in China and Japan for thousands of years, and virtually all regions of the world have used natural materials to treat human disease. It was clear that many plants, herbs, etc. contain components with powerful biological activities. The dawn of modern natural products chemistry began with the isolation of the active component, morphine, from opium. Subsequently, various alkaloids were isolated from medicinal plants and employed clinically. The discovery and the development of penicillin as a microbial metabolite opened up the era of antibiotics, which have saved countless lives in the past half century or so. The isolation and synthesis of steroid hormones resulted in the development of new concepts in molecular stereochemistry and organic synthetic techniques, as did the discovery of bioactive lipids such as prostaglandins and leukatrienes, bioactive peptides such as enkephalins and endetherines, and oligosaccharides, including glycoproteins. Further, the discovery of plant hormones has led to great strides in plant biotechnology, including plant tissue cultures, and derivatives of insect hormones and pheromones are now used as pesticides. Thus, applications of natural products chemistry have become all-pervasive in modern society. Apart from the extensive practical applications of natural products and their derivatives, natural products chemistry has played a central role in the development of modern organic chemistry as a result of its focus on structural and synthetic studies of often highly complex and inaccessible molecules. Biosynthetic studies have also attracted much attention, aiming to answer the questions of why and how such a large number and variety of compounds are synthesised by organisms. Researchers in the field of biosynthesis first focused on elucidation of the pathways of secondary metabolism, and then on the mechanisms, of the enzymes catalyzing the biosynthetic reactions. This was an extremely difficult task, because rather large amounts of enzymes are required for the investigation of reaction mechanisms and the enzyme proteins are often unstable and not easy to purify. However, in recent years the development of molecular biology has made gene and protein engineering rather routine. Thus, studies of mechanistic enzymology can now be conducted with cloned and overexpressed enzyme proteins. It has been shown that the enzymes responsible for the biosynthesis of antibiotics in Streptomyces spp. are encoded in gene clusters. Further, cloning and functional analysis of the genes associated with flavonoid biosynthesis should soon cast light on the interesting question of why flavonoids are ubiquitously present in plant leaves. Life is maintained not only by large molecules such as proteins and nucleic acids, but also by many small molecules which have essential and diverse roles in the physiology of living organisms. Such compounds often have highly specific interactions with target receptors, but the mechanisms involved largely remain to be explored. Current methodology means that this task can be addressed, and this in turn should lead to a host of new applications for natural products and their derivatives. The key may be an interdisciplinary approach taking account of both biological function and molecular behaviour based on precise structure recognition. As we increasingly understand the mechanisms of molecular recognition that operate in nature, many possibilities should open up for artificial control or modification of biological functions, as well as new challenges for synthetic organic chemists. Our intention in this book is to focus on such dynamic aspects of natural products chemistry. By dealing in detail with representative topics to which the most modern techniques of research have been applied, we hope to emphasize the value of combining traditional approaches to natural products chemists with current biochemical and molecular-biological ideas. Each chapter provides sufficient background information and experimental detail to make the subject accessible to non-specialists. It is our hope that these examples of recent progress in key areas of natural products chemistry will stimulate work in related topics by illustrating the power of a modern interdisciplinary approach to the subject.
Author:
Publisher: Elsevier
ISBN: 0081026919
Category : Science
Languages : en
Pages : 4266
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Book Description
Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience
Author: Jesiya Susan George
Publisher: CRC Press
ISBN: 1000401030
Category : Medical
Languages : en
Pages : 395
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Book Description
Here is an informative collection of peer-reviewed chapters on new and innovative holistic approaches to treat contemporary lifestyle diseases. The volume discusses the basics of holistic medicine along with detailed explanations of lifestyle diseases such as various types of cancers, health problems due to overnight mobile telephone usage, AIDS, arthritis, and asthma. The book also advocates several effective strategies that use a combination of nontraditional treatment approaches. The chapters discuss medicinal mushrooms in cancer therapy, employing Ayurveda to treat obesity, treating AIDS by using gene therapy and gene editing technology, and more. This volume will be of interest to open-minded and forward-thinking scientists, researchers, doctors, and other healthcare experts worldwide who endeavor to employ new holistic approaches for the treatment of contemporary lifestyle health issues.
Author: Guohui Lu
Publisher: Frontiers Media SA
ISBN: 2832503705
Category : Science
Languages : en
Pages : 359
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Book Description
Author: Debbie Steele
Publisher: Elsevier Health Sciences
ISBN: 0323791972
Category : Medical
Languages : en
Pages : 552
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Book Description
Gain the skills you need to provide safe and effective psychiatric nursing care! Keltner’s Psychiatric Nursing, 9th Edition provides a solid foundation in the knowledge required to manage and care for patients with psychiatric disorders. It features a unique, three-pronged approach to psychotherapeutic management emphasizing the nurse’s three primary tools: themselves and their relationship with patients, medications, and the therapeutic environment. New to this edition are Next Generation NCLEX® exam-style case studies to help you learn clinical judgment and prepare for success on the NCLEX. Known for its clear and friendly writing style, this text covers psychiatric nursing like no other book on the market. UNIQUE! Practical, three-pronged approach to psychotherapeutic management includes: 1) the therapeutic nurse-patient relationship, 2) psychopharmacology, and 3) milieu management. UNIQUE! Norm’s Notes offer personal, helpful tips from Norman Keltner — an expert educator and the book’s erstwhile author — in each chapter. UNIQUE! Putting It All Together summaries are provided at the end of each psychopathology chapter. DSM-5 information is integrated throughout the text, along with new ICNP content. Nursing care plans highlight the nurse’s role in psychiatric care, emphasizing assessment, planning, nursing diagnoses, implementation, and evaluation for specific disorders. Case studies depict psychiatric disorders and show the development of effective nursing care strategies. Critical thinking questions help you develop clinical reasoning skills. Family Issues boxes highlight the issues that families must confront when a member suffers from mental illness. Patient and Family Education boxes highlight information that the nurse should provide to patients and families. Learning resources on the Evolve website include lecture slides, psychotropic drug monographs, and NCLEX® exam-style review questions. NEW! Next Generation NCLEX® (NGN) examination-style case studies and NGN item types are included for five of the major mental health disorders, allowing you to apply clinical judgment skills. NEW! Updated Clinical Examples discuss real-world situations relating to mental health. NEW! COVID-19 resources and research includes information relevant to psychiatric nursing care. NEW! International Classification for Nursing Practice (ICNP) nursing diagnoses, from the International Council of Nurses, include straightforward, evidence-based terminology that is easily translatable across settings and disciplines.
Author: Goutam Brahmachari
Publisher: John Wiley & Sons
ISBN: 3527341862
Category : Medical
Languages : en
Pages : 372
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Book Description
Focusing on the molecular mechanisms of powerful naturally occurring agents and their implication for drug discovery, this timely book presents an overview of the most recent research advances in the field of bioactive natural products and natural drug formulations to combat today's destructive diseases. To this extent, the authors discuss the most severe neurological disorders in our modern civilization, such as Alzheimer's, Parkinson's and Huntington's disease, as well as ischemic brain stroke and depression. The emerging diversity of active compounds is covered in detail, including flavonoids, cannabinoids and oleanolic acid, while experts in the field explain the chemistry, mode of action and clinical aspects of novel neuroprotective natural products. In each case, the benefits of treatments using natural products are addressed from the perspective of modern as well as traditional medicine. With its multidisciplinary viewpoint, this is the ideal companion for medicinal and natural products chemists as well as neuroscientists, biochemists, pharmacologists, neurobiologists, and phytotherapists.
