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Author: Gianfranco Pancino
Publisher: Academic Press
ISBN: 0123877156
Category : Medical
Languages : en
Pages : 362
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Book Description
A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field
Author: Gianfranco Pancino
Publisher: Academic Press
ISBN: 0123877156
Category : Medical
Languages : en
Pages : 362
Get Book Here
Book Description
A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field
Author: Aftab A. Ansari
Publisher: Elsevier
ISBN: 9780124047341
Category : Medical
Languages : en
Pages : 0
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Book Description
Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant.
Author: Edward Hooper
Publisher: Back Bay
ISBN: 9780316371377
Category : Medical
Languages : en
Pages : 1118
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Book Description
A British medical journalist offers a meticulously researched look at HIV and its potential source, discussing the history of this lethal epidemic, analyzing a number of theories concerning its origins, and investigating current scientific inquiries into HIV, AIDS, and the search for a cure. Reprint. 15,000 first printing.
Author: Aftab A. Ansari
Publisher: Newnes
ISBN: 0124051677
Category : Medical
Languages : en
Pages : 415
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Book Description
Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant. - Summarizes the past 30 years of research in this field and describes the latest developments in AIDS research using nonhuman primate animal models - Provides insights into how this large body of scientific work can be translated into novel approaches to treat and prevent HIV - Highlights the areas that merit future pursuit, focusing on potential applications for the treatment and prevention of HIV infection
Author: Christian R. Abee
Publisher: Academic Press
ISBN: 0123978386
Category : Medical
Languages : en
Pages : 867
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Book Description
The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. - Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research - Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information - Includes four color images throughout
Author: Keith A. Crandall
Publisher: JHU Press
ISBN: 9780801861512
Category : Medical
Languages : en
Pages : 524
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Book Description
Wolinsky.-- "European Molecular Biology Organization Reports"
Author: Thomas J. Hope
Publisher:
ISBN: 9781461496106
Category : AIDS (Disease)
Languages : en
Pages :
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Book Description
Author: H. Schuitemaker
Publisher: Springer Science & Business Media
ISBN: 9780792361961
Category : Medical
Languages : en
Pages : 300
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Book Description
Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS). The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. In addition, more fundamental aspects of HIV-1 infection are reviewed. These include the biology of the virus and the novel insights in AIDS pathogenesis. Not only is the significance of an HIV-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with T-cell destruction. Finally, the book discusses the currently used laboratory markers that allow for monitoring of the clinical course of infection.
Author: Trudy R. Turner
Publisher: Cambridge University Press
ISBN: 110867643X
Category : Science
Languages : en
Pages :
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Book Description
Living across Africa and the Caribbean, this widely dispersed primate population must adapt to different environmental challenges. How do members of the genus Chlorocebus live in desert-like conditions and in areas with freezing temperatures and snow in winter? This book examines the ways these primates adapt genetically, hormonally, physically and behaviourally to their changing landscapes. It features summary chapters for major topics such as behavioural ecology, life history, taxonomy, genetics and ethnoprimatology. Shorter essays supplement the work, with experts detailing their particular research on these primates. The combination of scholarship provides both a comprehensive view of this adaptable genus while enabling the reader to gain depth in specific topics. Developed from a symposium, this book combines decades of experience working with savanna monkeys into a tangible resource, for students and researchers in primatology as well as evolutionary and behavioural studies.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309169739
Category : Medical
Languages : en
Pages : 176
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Book Description
Zoonotic diseases represent one of the leading causes of illness and death from infectious disease. Defined by the World Health Organization, zoonoses are "those diseases and infections that are naturally transmitted between vertebrate animals and man with or without an arthropod intermediate." Worldwide, zoonotic diseases have a negative impact on commerce, travel, and economies. In most developing countries, zoonotic diseases are among those diseases that contribute significantly to an already overly burdened public health system. In industrialized nations, zoonotic diseases are of particular concern for at-risk groups such as the elderly, children, childbearing women, and immunocompromised individuals. The Emergence of Zoonotic Diseases: Understanding the Impact on Animal and Human Health, covers a range of topics, which include: an evaluation of the relative importance of zoonotic diseases against the overall backdrop of emerging infections; research findings related to the current state of our understanding of zoonotic diseases; surveillance and response strategies to detect, prevent, and mitigate the impact of zoonotic diseases on human health; and information about ongoing programs and actions being taken to identify the most important needs in this vital area.
