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Author: Joan M. Boggs
Publisher:
ISBN: 9781604566994
Category : Myelin basic protein
Languages : en
Pages : 0
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Book Description
The compact myelin sheath formed around nerve axons speeds up nerve conduction and also nurtures the axon. Destruction of this sheath in demyelinating diseases such as multiple sclerosis (MS) results in nerve conduction failure and neurodegeneration. Myelin basic protein (MBP) is the second most abundant protein of central nervous system (CNS) myelin (after the proteolipid protein), representing about 30 % of the total myelin protein and about 10 % of myelin by weight. It is also present in peripheral nervous system (PNS) myelin but as a lower percentage of the total protein. This book addresses the issue of Myelin and the way it binds to negatively-charged lipids on the cytosolic surfaces of the processes and is responsible for adhesion of these surfaces of myelin in the CNS, thus forming the major dense line observed by electron microscopy.
Author: Joan M. Boggs
Publisher:
ISBN: 9781604566994
Category : Myelin basic protein
Languages : en
Pages : 0
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Book Description
The compact myelin sheath formed around nerve axons speeds up nerve conduction and also nurtures the axon. Destruction of this sheath in demyelinating diseases such as multiple sclerosis (MS) results in nerve conduction failure and neurodegeneration. Myelin basic protein (MBP) is the second most abundant protein of central nervous system (CNS) myelin (after the proteolipid protein), representing about 30 % of the total myelin protein and about 10 % of myelin by weight. It is also present in peripheral nervous system (PNS) myelin but as a lower percentage of the total protein. This book addresses the issue of Myelin and the way it binds to negatively-charged lipids on the cytosolic surfaces of the processes and is responsible for adhesion of these surfaces of myelin in the CNS, thus forming the major dense line observed by electron microscopy.
Author: Anthony P. Nicholas
Publisher: Springer Science & Business Media
ISBN: 1461483174
Category : Medical
Languages : en
Pages : 438
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Book Description
Deimination is a relatively new post-translational modification of proteins, whose recognition is ever-increasing. First linked to the pathology of rheumatoid arthritis (RA), deimination is a process by which selected positively charged arginine amino acids are converted to neutral citrulline amino acids by the peptidyl arginine deiminase (PAD) family of enzymes. Although the medical literature is rich with articles about the possible significance of deiminated proteins in RA, Protein Deimination in Human Health and Disease is the first publication to compile this knowledge and the growing amount of new information now known about the presence of deiminated proteins in the eye, skin, hair, gums, lung and nervous system, as well. As a result, this process has now been linked to numerous additional conditions besides RA, including cancer, glaucoma, Alzheimer's disease, Parkinson's disease, multiple sclerosis, spinal cord and peripheral nerve injury, Creutzfeldt-Jakob disease, among many others. Chronicling the earliest studies of deimination up to the present, this volume distills what is currently known about citrullination of proteins in the human body and is the first book of its kind on the topic.
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Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Norio Nakamura
Publisher: Springer Science & Business Media
ISBN: 4431682317
Category : Medical
Languages : en
Pages : 498
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Book Description
The dawn of neurosurgery can be traced back to the first description preserved in the Edwin Smith papyrus' (3000 Be) which dealt with head and spinal injury. In the course of 5000 years, since the first record in Egypt, advances in lifestyle and technology have brought about our modern civilized society. However, as a result of civilization, currently the total number of severe head injuries worldwide is believed to exceed 10000000 and the number of severe spinal injuries is believed to be more than 75 000 each year. This means that central nervous system injury is not only the oldest topic in neurosurgery, but that it is also of critical importance in modern life. Taking these problems into consideration, the International Neurotraumatology Committee was organized in 1965 as an affiliated Committee of the World Federation of Neurosurgical Societies. The first scientific meeting was convened by the Committee in Marseilles in 1970. Nine further meetings were subsequently held, in Europe, Africa, and South America. The meeting was first named "International Conference on Recent Advances in Neurotrauma tology" (ICRAN) by Professor Phillip Harris, when the scientific meeting was held in Edinburgh in 1982. The tenth meeting, (ICRAN 1992), the first one in Asia, was held at Karuizawa, Japan, from September 23rd to 26th, 1992.
Author: Brett E. Skolnick
Publisher: Academic Press
ISBN: 0128041013
Category : Medical
Languages : en
Pages : 408
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Book Description
Handbook of Neuroemergency Clinical Trials, Second Edition, focuses on the practice of clinical trials in acute neuroscience populations, or what have been called neuroemergencies. Neuroemergencies are complex, life-threatening diseases and disorders, often with devastating consequences, including death or disability. The overall costs are staggering in terms of annual incidence and costs associated with treatment and survival, yet despite their significance as public health issues, there are few drugs and devices available for definitive treatment. The book focuses on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. This volume provides neurologists, neuroscientists, and drug developers with a more complete understanding of the scientific and medical issues of relevance in designing and initiating clinical development plans for novel drugs intended for acute neuroscience populations. The editors provide the best understanding of the pitfalls associated with acute CNS drug development and the best information on how to approach and solve issues that have plagued drug development. Presents a comprehensive overview on clinical trials and drug development challenges in acute neuroscience populations Provides neurologists, neuroscientists and drug developers with a complete understanding of scientific and medical issues related to designing clinical trials Edited by leaders in the field who have designed and managed over 50 neuroemergency clinical trials
Author:
Publisher: ScholarlyEditions
ISBN: 146494931X
Category : Medical
Languages : en
Pages : 28
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Book Description
Myelin Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Myelin Proteins in a compact format. The editors have built Myelin Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Myelin Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Myelin Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Abel Lajtha
Publisher: Springer Science & Business Media
ISBN: 0387326707
Category : Medical
Languages : en
Pages : 332
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Book Description
The nervous system is highly fragile, especially during aging, illness and trauma. This book addresses a small sampling of major constituents of neural function at the cellular and molecular level that play crucial roles in development and aging.
Author: Gregory Atkins
Publisher: Cambridge University Press
ISBN: 1139851063
Category : Medical
Languages : en
Pages : 141
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Book Description
Multiple sclerosis is the most common debilitating neurological disease in people under the age of forty in the developed world. Many publications cover medical and clinical approaches to the disease; however, The Biology of Multiple Sclerosis provides a clear and concise up-to-date overview of the scientific literature on the various theories of MS pathogenesis. Covering the main elements of scientific research into multiple sclerosis, the book contains chapters on the neuropathology of the disease as well as an account of the most extensively used animal model experimental autoimmune encephalomyelitis. The book contains chapters regarding the role of viruses in the development of multiple sclerosis. Viruses have long been implicated and chapters on animal models based on virus infection, as well as their possible role in the etiology of MS, are included. Of interest to MS researchers, the book is written to also be of value to postgraduate and medical students.
Author: Michael E. Hoffer
Publisher: Academic Press
ISBN: 0128125489
Category : Medical
Languages : en
Pages : 453
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Book Description
Mild traumatic Brain Injury (mTBI or Concussion) is an increasingly common public health issue in sports, military environments, and life in today’s active world. Despite a great deal of study and public attention to this disorder, knowledge about optimal diagnostic, prognostic, and treatment information remains lacking. Neurosensory symptoms have been shown to be the most frequent complications of mTBI in both the acute and chronic setting. Neurosensory Disorders in Mild Traumatic Brain Injury brings together both the basic science work as well as the clinical work in mTBI into one volume to provide a comprehensive examination of the neurosensory issues associated with this disorder. Coverage includes chapters on defining mild Traumatic Brain Injury, neurosensory consequences, neurosensory disorders in clinical practice, and diagnosis and treatment for neurosensory disorders in mTBI. This book is written for clinicians, researchers, residents and students in neurology and neuroscience. Provides a comprehensive examination of the neurosensory issues associated with mild Traumatic Brain Injury and concussion Brings together both the basic science work and the clinical work in mTBI into a single volume Helps clinicians understand the best diagnosis and treatment paths and puts current research into perspective for researchers
Author: Agata Zienowicz
Publisher:
ISBN:
Category :
Languages : en
Pages :
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