Multicomponent Diffusion Involving Macromolecules PDF Download
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Author: E. L. Cussler
Publisher:
ISBN:
Category : Diffusion
Languages : en
Pages : 248
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Book Description
Author: E. L. Cussler
Publisher:
ISBN:
Category : Diffusion
Languages : en
Pages : 248
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Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Diffusion occurs in many biological, medical, laboratory and manufacturing processes. In this dissertation, multicomponent diffusion has been investigated for solutions containing high molecular-weight solutes using Rayleigh interferometry and dynamic light scattering (DLS) at 25 ðC. The first objective of this dissertation is to experimentally and theoretically investigate the effect of macromolecule polydispersity on macromolecule diffusion in water. We show diffusion measurements performed by Rayleigh interferometry can be used to characterize macromolecular polydispersity, and diffusion measurements performed by DLS can significantly differ from those obtained by Rayleigh interferometry if macromolecules are highly polydisperse. For macromolecule-additive-solvent mixtures, a corrective procedure was successfully developed to remove polydispersity effects and treat these systems as ternary systems. The second objective of this dissertation is to investigate multicomponent diffusion of a model macromolecule-additive-solvent ternary system. We use Rayleigh interferometry to determine the four multicomponent diffusion coefficients for the poly(ethylene glycol)-di(ethylene glycol)-water ternary system. This investigation shows how multicomponent diffusion can be used to 1) characterize macromolecule-additive thermodynamic interactions; 2) examine the role of preferential interactions and macromolecule solvation on the phenomenon of coupled diffusion. These studies were extended to poly(ethylene glycol)-salt-water ternary systems to characterize macromolecule-salt thermodynamic interactions. The third goal of this dissertation is to investigate multicomponent diffusion of drug-carrier-water systems. In pharmaceutical industry, diffusion parameters are crucial for modeling and predicting drug controlled release. Carriers, such as micelles can be added to drug formulations to enhance drug bioavailability and prolong drug retention. We use Rayleigh interferometry to dete.
Author: E. L. Cussler
Publisher: Elsevier
ISBN: 1483102009
Category : Science
Languages : en
Pages : 187
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Book Description
Multicomponent Diffusion discusses the multicomponent diffusion of the three phases of matter. The book is comprised of nine chapters that cover studies of multicomponent diffusion and mass transfer with an emphasis on the chemical characteristics responsible for multicomponent diffusion. Chapter 1 provides an introductory discourse about multicomponent diffusion. Chapter 2 discusses binary diffusion, while Chapter 3 covers multicomponent flux equation. The measurement of ternary diffusion and the estimation of ternary diffusion coefficients are also explained in the book. A chapter then covers the interacting systems, and the subsequent chapter talks about membranes without mobile carriers. The text also discusses carrier-containing membranes and the multicomponent mass transfer. The book will be of great use to researchers and professionals whose work requires a good understanding of multicomponent diffusion.
Author: Huixian Zhang
Publisher:
ISBN:
Category : Diffusion
Languages : en
Pages :
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Book Description
Diffusion occurs in many biological, medical, laboratory and manufacturing processes. In this dissertation, multicomponent diffusion has been investigated for solutions containing high molecular-weight solutes using Rayleigh interferometry and dynamic light scattering (DLS) at 25° C. The first objective of this dissertation is to experimentally and theoretically investigate the effect of macromolecule polydispersity on macromolecule diffusion in water. We show diffusion measurements performed by Rayleigh interferometry can be used to characterize macromolecular polydispersity, and diffusion measurements performed by DLS can significantly differ from those obtained by Rayleigh interferometry if macromolecules are highly polydisperse. For macromolecule-additive-solvent mixtures, a corrective procedure was successfully developed to remove polydispersity effects and treat these systems as ternary systems. The second objective of this dissertation is to investigate multicomponent diffusion of a model macromolecule-additive-solvent ternary system. We use Rayleigh interferometry to determine the four multicomponent diffusion coefficients for the poly(ethylene glycol)-di(ethylene glycol)-water ternary system. This investigation shows how multicomponent diffusion can be used to 1) characterize macromolecule-additive thermodynamic interactions; 2) examine the role of preferential interactions and macromolecule solvation on the phenomenon of coupled diffusion. These studies were extended to poly(ethylene glycol)-salt-water ternary systems to characterize macromolecule-salt thermodynamic interactions. The third goal of this dissertation is to investigate multicomponent diffusion of drug-carrier-water systems. In pharmaceutical industry, diffusion parameters are crucial for modeling and predicting drug controlled release. Carriers, such as micelles can be added to drug formulations to enhance drug bioavailability and prolong drug retention. We use Rayleigh interferometry to determine the four multicomponent diffusion coefficients for drug-micelle-water ternary systems. Hydrocortisone and potassium naproxenate were used as model nonionic and ionic drugs respectively. The micelle of the surfactant tyloxapol was chosen as a model carrier. Drug solubility was measured as a function of surfactant concentration to quantitatively characterize drug-micelle binding. A theoretical model, describing coupled diffusion in micelle solutions and taking into account drug-micelle binding, counter-ion effects and micelle salvation, was successfully developed for both nonionic and ionic drugs. This study contributes to the fundamental understanding of drug diffusion in the presence of nano-carriers and provides guidance for the development of accurate models of diffusion-based controlled release.
Author: Louis Edward Furlong
Publisher:
ISBN:
Category : Diffusion
Languages : en
Pages : 642
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Book Description
Author: Kamalesh Sirkar
Publisher: Cambridge University Press
ISBN: 0521895731
Category : Science
Languages : en
Pages : 923
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Book Description
A modern separation process textbook written for advanced undergraduate and graduate level courses in chemical engineering.
Author: J. A. Wesselingh
Publisher:
ISBN:
Category : Mass transfer
Languages : en
Pages : 344
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Book Description
Author: Stanislaw Sieniutycz
Publisher: Elsevier
ISBN: 0128093390
Category : Technology & Engineering
Languages : en
Pages : 740
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Book Description
Thermodynamic Approaches in Engineering Systems responds to the need for a synthesizing volume that throws light upon the extensive field of thermodynamics from a chemical engineering perspective that applies basic ideas and key results from the field to chemical engineering problems. This book outlines and interprets the most valuable achievements in applied non-equilibrium thermodynamics obtained within the recent fifty years. It synthesizes nontrivial achievements of thermodynamics in important branches of chemical and biochemical engineering. Readers will gain an update on what has been achieved, what new research problems could be stated, and what kind of further studies should be developed within specialized research. Presents clearly structured chapters beginning with an introduction, elaboration of the process, and results summarized in a conclusion Written by a first-class expert in the field of advanced methods in thermodynamics Provides a synthesis of recent thermodynamic developments in practical systems Presents very elaborate literature discussions from the past fifty years
Author: Gennadiĭ Efremovich Zaikov
Publisher: VSP
ISBN: 9789067640770
Category : Science
Languages : en
Pages : 336
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Book Description
Diffusion is the process of transport of a substance in space due to thermal migration of 'kinetic' particles. This book firstly determines the general aspects of diffusion in polymers and goes onto to explore characteristics of electrolyte diffusion in different polymers, acids; water diffusion and chemical reactions.
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
