Multicolor Fluorescence Guided Surgery for Head and Neck Cancer PDF Download
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Category : Biomedical engineering
Languages : en
Pages : 0
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Book Description
This project aims to take a novel, NIR nerve-specific fluorophore LGW05-754 and test its compatibility with a tumor-targeting affibody molecule, ABY-0296 that has been labeled with IRDye800CW. The overall goal is to show that these two molecules can be co-administered to show the nerves and tumor cells in real-time to better assist surgeons in a full resection while avoiding iatrogenic nerve damage.
Author:
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ISBN:
Category : Biomedical engineering
Languages : en
Pages : 0
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Book Description
This project aims to take a novel, NIR nerve-specific fluorophore LGW05-754 and test its compatibility with a tumor-targeting affibody molecule, ABY-0296 that has been labeled with IRDye800CW. The overall goal is to show that these two molecules can be co-administered to show the nerves and tumor cells in real-time to better assist surgeons in a full resection while avoiding iatrogenic nerve damage.
Author:
Publisher:
ISBN: 9789461824080
Category :
Languages : en
Pages :
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Author: Robert Hoffman
Publisher: Academic Press
ISBN: 0128126779
Category : Medical
Languages : en
Pages : 296
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Book Description
Strategies for Curative Fluorescence-Guided Surgery of Cancer is the first book to discuss how fluorescence-guided surgery can be successfully used during surgeries with several tumor types. FGS is one of the most exciting emerging modalities of surgery, especially cancer surgery, as it potentially allows the surgeon to visualize the actual margin of the tumor, thus greatly increasing the possibility of curative resection. The book discusses the applicability of FGS for several types of cancer, such as pancreatic cancer, liver metastasis, soft-tissue sarcoma, glioma, melanoma, and breast and lung cancer. This book is a valuable resource for cancer surgeons, cancer researchers and members of several other areas in the biomedical field who are interested in understanding this powerful technique. Presents an overview of fluorescence-guided surgery Explains general strategies for curative fluorescence-guided surgery and their applicability for each major tumor type Discusses the current and future achievements of FGS as a precise technique for cancer surgeries
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Category :
Languages : en
Pages : 0
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ISBN: 9789464163599
Category :
Languages : en
Pages : 0
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English summary The main objective for curative oncologic surgery is to remove tumor tissue in conjunction with tumor-free margins. The essence for surgeons hereby lies in distinguishing healthy from diseased tissue to ensure satisfying prognosis. Today, surgeons make this important distinction based on tissue palpation and visual appearance, occasionally followed by frozen section analysis (FSA) – a technique that has substantial flaws, especially in complex surgery such as the head and neck. This might in part explain the high rates of tumor-positive margins and subsequent suboptimal overall survival rates afflicted with surgical head and neck oncology. The past decades, intraoperative imaging techniques utilizing near-infrared (NIR) fluorescence have been developed to aid surgeons in distinguishing tumor from healthy adjacent tissue. These real-time imaging techniques provide an essential step towards improving surgical outcome through enhanced tumor visualization and thereby increase patient survival. The first targeted fluorescent agents have been evaluated in multiple early phase trials and are now entering large scale clinical testing. It is now that we can start to monitor where the true clinical capacity of this technique lies. This thesis aims to lay a clinical foundation and explore the future possibilities of intraoperative fluorescence-guidance for surgical head and neck oncology. By providing an overview of various in situ and ex vivo imaging strategies, the work aims to illustrate the clinical possibilities and subsequently smoothen the transition of fluorescence imaging into today’s clinic.
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309670950
Category : Medical
Languages : en
Pages : 319
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Book Description
The Social Security Administration (SSA) administers two programs that provide disability benefits: the Social Security Disability Insurance (SSDI) program and the Supplemental Security Income (SSI) program. SSDI provides disability benefits to people (under the full retirement age) who are no longer able to work because of a disabling medical condition. SSI provides income assistance for disabled, blind, and aged people who have limited income and resources regardless of their prior participation in the labor force. Both programs share a common disability determination process administered by SSA and state agencies as well as a common definition of disability for adults: "the inability to engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment which can be expected to result in death or which has lasted or can be expected to last for a continuous period of not less than 12 months." Disabled workers might receive either SSDI benefits or SSI payments, or both, depending on their recent work history and current income and assets. Disabled workers might also receive benefits from other public programs such as workers' compensation, which insures against work-related illness or injuries occurring on the job, but those other programs have their own definitions and eligibility criteria. Selected Health Conditions and Likelihood of Improvement with Treatment identifies and defines the professionally accepted, standard measurements of outcomes improvement for medical conditions. This report also identifies specific, long-lasting medical conditions for adults in the categories of mental health disorders, cancers, and musculoskeletal disorders. Specifically, these conditions are disabling for a length of time, but typically don't result in permanently disabling limitations; are responsive to treatment; and after a specific length of time of treatment, improve to the point at which the conditions are no longer disabling.
Author: Margarida Barroso
Publisher: CRC Press
ISBN: 1351704494
Category : Science
Languages : en
Pages : 444
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Book Description
This book offers an overview of imaging techniques used to investigate cells and tissue in their native environment. It covers the range of imaging approaches used, as well as the application of those techniques to the study of biological processes in cells and whole tissues within living organisms.
Author: Wolfhard Semmler
Publisher: Springer
ISBN: 9783540727170
Category : Medical
Languages : en
Pages : 280
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Book Description
The aim of this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach need to be closely linked with the biologic application of the probe (i.e. nanoparticles and microbubbles). Various chemical strategies are discussed and related to the biologic applications. Reporter-gene imaging is being addressed not only in experimental protocols, but also first clinical applications are discussed. Finally, strategies of imaging to characterize apoptosis and angiogenesis are described and discussed in the context of possible clinical translation.
Author:
Publisher: Newnes
ISBN: 0444536337
Category : Science
Languages : en
Pages : 4052
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Book Description
Comprehensive Biomedical Physics, Ten Volume Set is a new reference work that provides the first point of entry to the literature for all scientists interested in biomedical physics. It is of particularly use for graduate and postgraduate students in the areas of medical biophysics. This Work is indispensable to all serious readers in this interdisciplinary area where physics is applied in medicine and biology. Written by leading scientists who have evaluated and summarized the most important methods, principles, technologies and data within the field, Comprehensive Biomedical Physics is a vital addition to the reference libraries of those working within the areas of medical imaging, radiation sources, detectors, biology, safety and therapy, physiology, and pharmacology as well as in the treatment of different clinical conditions and bioinformatics. This Work will be valuable to students working in all aspect of medical biophysics, including medical imaging and biomedical radiation science and therapy, physiology, pharmacology and treatment of clinical conditions and bioinformatics. The most comprehensive work on biomedical physics ever published Covers one of the fastest growing areas in the physical sciences, including interdisciplinary areas ranging from advanced nuclear physics and quantum mechanics through mathematics to molecular biology and medicine Contains 1800 illustrations, all in full color
Author: Giuliano Mariani
Publisher: Springer Science & Business Media
ISBN: 0387383271
Category : Medical
Languages : en
Pages : 319
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Book Description
This multidisciplinary textbook is designed to be the standard on the subject and is geared for use by physicians who are involved in the care and/or diagnosis of cancer patients. Comprehensive coverage is provided on all aspects of radioguided surgery. Practical information is readily accessible and throughout there is an emphasis on improved decision making. Tables present the indications, performance, and interpretation of procedures at a glance. A wealth of illustrations, including a full-color insert, enhances the application of new concepts.
