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Author: Albrecht Messerschmidt
Publisher: World Scientific
ISBN: 9814498807
Category : Science
Languages : en
Pages : 476
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Book Description
The biological activation of dioxygen is a key reaction in biological systems. Enzymes involved in direct oxygen activation are oxidases and oxygenases. Multi-copper oxidases are an important class of oxidases reducing dioxygen in a four-electron reduction to water with concomitant one-electron oxidation of the reducing substrate. The progress in the characterization and understanding of the structure and function of these enzymes has advanced so tremendously over the last ten years that the publication of a book documenting these achievements has been overdue. Especially the recent discovery of a key role of the FET3 protein of Saccharomyces cerevisae, a multi-copper oxidase, in iron metabolism of this eukaryote has underpinned the function of the plasma multi-copper oxidase ceruloplasmin in vetebrate iron transport. The lately determined x-ray structure of human ceruloplasmin confirms its close structural relatedness to the plant multi-copper oxidases ascorbate oxidase and laccase and due to strong amino-acid sequence similarities has allowed to construct a useful model of the more distantly related blood-clotting factor VIII. This book contains review articles from experts in the field, dealing with modern spectroscopy, enzyme kinetics, bioinorganic chemistry, x-ray crystallography, electron transfer reactions, molecular biology, medical aspects and potential industrial applications of the three main members of multi-copper oxidases, i.e., laccase, ascorbate oxidase and ceruloplasmin. Contents: Early and More Recent History in the Research on Multi-Copper Oxidases (Bo G Malmström)Spatial Structures of Ascorbate Oxidase, Laccase and Related Proteins: Implications for the Catalytic Mechanism (A Messerschmidt)The Structure of Human Ceruloplasmin at 3.1 Å Resolution (P F Lindley et al.)Spectroscopy of Multi-Copper Oxidases (E I Solomon et al.)Bioinorganic Chemistry of Laccase (D R McMillin & M K Eggleston)Kinetic Studies on Polyporus and Tree Laccases (B Reinhammar)Fungal Laccases: Role in Delignification and Possible Industrial Applications (M Smith, C F Thurston & D A Wood)Spectroscopy of Cucumber Ascorbate Oxidase and Fungal Laccase (T Sakurai & S Suzuki)Biological Function and Enzyme Kinetics of Ascorbate Oxidase (L Avigliano & A Finazzi-Agrò)The Biology of Human Ceruloplasmin (Z Leah Harris, H Morita & J D Gitlin)Molecular Properties of Ceruloplasmin from Different Species (L Calabrese & G Musci)Electron Transfer Reactions in Multi-Copper Oxidases (O Farver & I Pecht)Redox Properties of Blue Multi-Copper Oxidases (P M H Kroneck)Model Compounds for Multi-Copper Oxidases (P Chaudhuri)199mHg-Derivatives of Laccase and Ascorbate Oxidase: A Hyperfine Spectroscopic Study (T Butz & W Tröger). Readership: Bioinorganic chemists, biochemists, clinical chemists and biophysicists. keywords:Metalloproteins;Laccase;Ceruloplasmin;Ascorboate Oxidase;FET3 Protein;Electron Transfer;EPR-Spectroscopy;Magnetic Circular Dichroism Spectroscopy;Aceruloplasminemia;Iron Transport
Author: Albrecht Messerschmidt
Publisher: World Scientific
ISBN: 9814498807
Category : Science
Languages : en
Pages : 476
Get Book
Book Description
The biological activation of dioxygen is a key reaction in biological systems. Enzymes involved in direct oxygen activation are oxidases and oxygenases. Multi-copper oxidases are an important class of oxidases reducing dioxygen in a four-electron reduction to water with concomitant one-electron oxidation of the reducing substrate. The progress in the characterization and understanding of the structure and function of these enzymes has advanced so tremendously over the last ten years that the publication of a book documenting these achievements has been overdue. Especially the recent discovery of a key role of the FET3 protein of Saccharomyces cerevisae, a multi-copper oxidase, in iron metabolism of this eukaryote has underpinned the function of the plasma multi-copper oxidase ceruloplasmin in vetebrate iron transport. The lately determined x-ray structure of human ceruloplasmin confirms its close structural relatedness to the plant multi-copper oxidases ascorbate oxidase and laccase and due to strong amino-acid sequence similarities has allowed to construct a useful model of the more distantly related blood-clotting factor VIII. This book contains review articles from experts in the field, dealing with modern spectroscopy, enzyme kinetics, bioinorganic chemistry, x-ray crystallography, electron transfer reactions, molecular biology, medical aspects and potential industrial applications of the three main members of multi-copper oxidases, i.e., laccase, ascorbate oxidase and ceruloplasmin. Contents: Early and More Recent History in the Research on Multi-Copper Oxidases (Bo G Malmström)Spatial Structures of Ascorbate Oxidase, Laccase and Related Proteins: Implications for the Catalytic Mechanism (A Messerschmidt)The Structure of Human Ceruloplasmin at 3.1 Å Resolution (P F Lindley et al.)Spectroscopy of Multi-Copper Oxidases (E I Solomon et al.)Bioinorganic Chemistry of Laccase (D R McMillin & M K Eggleston)Kinetic Studies on Polyporus and Tree Laccases (B Reinhammar)Fungal Laccases: Role in Delignification and Possible Industrial Applications (M Smith, C F Thurston & D A Wood)Spectroscopy of Cucumber Ascorbate Oxidase and Fungal Laccase (T Sakurai & S Suzuki)Biological Function and Enzyme Kinetics of Ascorbate Oxidase (L Avigliano & A Finazzi-Agrò)The Biology of Human Ceruloplasmin (Z Leah Harris, H Morita & J D Gitlin)Molecular Properties of Ceruloplasmin from Different Species (L Calabrese & G Musci)Electron Transfer Reactions in Multi-Copper Oxidases (O Farver & I Pecht)Redox Properties of Blue Multi-Copper Oxidases (P M H Kroneck)Model Compounds for Multi-Copper Oxidases (P Chaudhuri)199mHg-Derivatives of Laccase and Ascorbate Oxidase: A Hyperfine Spectroscopic Study (T Butz & W Tröger). Readership: Bioinorganic chemists, biochemists, clinical chemists and biophysicists. keywords:Metalloproteins;Laccase;Ceruloplasmin;Ascorboate Oxidase;FET3 Protein;Electron Transfer;EPR-Spectroscopy;Magnetic Circular Dichroism Spectroscopy;Aceruloplasminemia;Iron Transport
Author: Sreedhar Kilaru
Publisher: Cuvillier Verlag
ISBN: 3867270961
Category :
Languages : en
Pages : 398
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Book Description
Author: Kenji Kano
Publisher: Springer Nature
ISBN: 9811589607
Category : Science
Languages : en
Pages : 135
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Book Description
This book covers the fundamental aspects of the electrochemistry and redox enzymes that underlie enzymatic bioelectrocatalysis, in which a redox enzyme reaction is coupled with an electrode reaction. Described here are the basic concept and theoretical aspects of bioelectrocatalysis and the various experimental techniques and materials used to study and characterize related problems. Also included are the various applications of bioelectrocatalysis to bioelectrochemical devices including biosensors, biofuel cells, and bioreactors. This book is a unique source of information in the area of enzymatic bioelectrocatalysis, approaching the subject from a cross-disciplinary point of view.
Author: Kenneth D. Karlin
Publisher: John Wiley & Sons
ISBN: 1118094352
Category : Science
Languages : en
Pages : 417
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Book Description
Covers the vastly expanding subject of oxidative processes mediated by copper ions within biological systems Copper-mediated biological oxidations offer a broad range of fundamentally important and potentially practical chemical processes that cross many chemical and pharmaceutical disciplines. This newest volume in the Wiley Series on Reactive Intermediates in Chemistry and Biology is divided into three logical areas within the topic of copper/oxygen chemistry— biological systems, theory, and bioinorganic models and applications—to explore the biosphere for its highly evolved and thus efficient oxidative transformations in the discovery of new types of interactions between molecular oxygen and copper ion. Featuring a diverse collection of subject matter unified in one complete and comprehensive resource, Copper-Oxygen Chemistry probes the fundamental aspects of copper coordination chemistry, synthetic organic chemistry, and biological chemistry to reveal both the biological and chemical aspects driving the current exciting research efforts behind copper-oxygen chemistry. In addition, Copper-Oxygen Chemistry: Addresses the significantly increasing literature on oxygen-atom insertion and carbon-carbon bond-forming reactions as well as enantioselective oxidation chemistries Progresses from biological systems to spectroscopy and theory, and onward to bioinorganic models and applications Covers a wide array of reaction types such as insertion and dehydrogenation reactions that utilize the cheap, abundant, and energy-containing O2 molecule With thorough coverage by prominent authors and researchers shaping innovations in this growing field, this valuable reference is essential reading for bioinorganic chemists, as well as organic, synthetic, and pharmaceutical chemists in academia and industry.
Author: Fausto Almeida
Publisher: Frontiers Media SA
ISBN: 2889661326
Category : Science
Languages : en
Pages : 167
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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author: Timothy E. Machonkin
Publisher:
ISBN:
Category :
Languages : en
Pages : 670
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Book Description
Author: Amy Elizabeth Palmer
Publisher:
ISBN:
Category :
Languages : en
Pages : 464
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Book Description
Author: Surajit Das
Publisher: Elsevier
ISBN: 0443133212
Category : Science
Languages : en
Pages : 840
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Book Description
Microbial Diversity in the Genomic Era, Second Edition presents techniques used for microbial taxonomy and phylogeny, along with their applications and respective strengths and challenges. Though many advanced techniques for the identification of unknown bacterium are available in the genomic era, a far fewer number of the total microbial species have been discovered and identified to date. With that in mind, this book incorporates recently developed biosystematics methods and approaches to assess microbial taxonomy, with suitable recommendations for where to apply them across the range of bacterial identification and infectious disease research. Here, international researchers in the field first provide a broad overview of microbial genomics research and microbiome directed medicine, followed by sections on molecular tools for microbial diversity research, extremophilic microbial diversity, functional microbial diversity across application areas, microbial diversity and infectious disease research, and future directions for research. Step-by-step methodologies are provided for key techniques, along with applied case studies breaking down recent research studies into the practical components, illuminating pathways for new studies across the field. This new edition has been fully updated to address advances in the field of microbiome directed medicine, and whole genome sequencing for studying microbial diversity, considering both recent technological advances and new applications areas, from extremophile studies to the latest approaches in human microbiome analysis. Instructs in techniques used for microbial taxonomy and phylogeny, with discussions of their applications and respective pros and cons Reviews the evolving field of microbial typing and the genomic technologies that enable comparative metagenomic analysis of complex microbial environments Covers microbiome directed translational research, as well as whole genome sequencing for studying microbial diversity, with newly added research protocols and case studies Reviews future applications in the field of microbiome directed medicine Features chapter contributions from global experts in the field
Author: Martin G. Klotz
Publisher: Academic Press
ISBN: 0123812941
Category : Reference
Languages : en
Pages : 602
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Book Description
State-of-the-art update on methods and protocols dealing with the detection, isolation and characterization of macromolecules and their hosting organisms that facilitate nitrification and related processes in the nitrogen cycle as well as the challenges of doing so in very diverse environments. Provides state-of-the-art update on methods and protocols Deals with the detection, isolation and characterization of macromolecules and their hosting organisms Deals with the challenges of very diverse environments
Author: Xiaoyu Wang
Publisher: Springer
ISBN: 3662530686
Category : Technology & Engineering
Languages : en
Pages : 127
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Book Description
This book describes the fundamental concepts, the latest developments and the outlook of the field of nanozymes (i.e., the catalytic nanomaterials with enzymatic characteristics). As one of today’s most exciting fields, nanozyme research lies at the interface of chemistry, biology, materials science and nanotechnology. Each of the book’s six chapters explores advances in nanozymes. Following an introduction to the rise of nanozymes research in the course of research on natural enzymes and artificial enzymes in Chapter 1, Chapters 2 through 5 discuss different nanomaterials used to mimic various natural enzymes, from carbon-based and metal-based nanomaterials to metal oxide-based nanomaterials and other nanomaterials. In each of these chapters, the nanomaterials’ enzyme mimetic activities, catalytic mechanisms and key applications are covered. In closing, Chapter 6 addresses the current challenges and outlines further directions for nanozymes. Presenting extensive information on nanozymes and supplemented with a wealth of color illustrations and tables, the book offers an ideal guide for readers from disparate areas, including analytical chemistry, materials science, nanoscience and nanotechnology, biomedical and clinical engineering, environmental science and engineering, green chemistry, and novel catalysis.
