Author: Case Adams
Publisher: Logical Books
ISBN: 1936251310
Category : Medical
Languages : en
Pages : 416
Book Description
The mucosal membranes that cover our skin, sinuses, airways, digestive tracts and many other regions are critical to our health. Not only do they help protect our bodies from intruders and environmental toxins. They also provide many other critical functions, such as helping us digest our foods and helping us breathe. As a result, faulty or damaged mucosal membranes is also at the root of many serious health conditions, including allergies, asthma, COPD, GERD and others. This book illustrates the science behind our mucosal membranes: how they cause disease, how they can become damaged, and what we can do to repair them and keep them healthy.
Mucosal Membrane Health
Author: Case Adams
Publisher: Logical Books
ISBN: 1936251310
Category : Medical
Languages : en
Pages : 416
Book Description
The mucosal membranes that cover our skin, sinuses, airways, digestive tracts and many other regions are critical to our health. Not only do they help protect our bodies from intruders and environmental toxins. They also provide many other critical functions, such as helping us digest our foods and helping us breathe. As a result, faulty or damaged mucosal membranes is also at the root of many serious health conditions, including allergies, asthma, COPD, GERD and others. This book illustrates the science behind our mucosal membranes: how they cause disease, how they can become damaged, and what we can do to repair them and keep them healthy.
Publisher: Logical Books
ISBN: 1936251310
Category : Medical
Languages : en
Pages : 416
Book Description
The mucosal membranes that cover our skin, sinuses, airways, digestive tracts and many other regions are critical to our health. Not only do they help protect our bodies from intruders and environmental toxins. They also provide many other critical functions, such as helping us digest our foods and helping us breathe. As a result, faulty or damaged mucosal membranes is also at the root of many serious health conditions, including allergies, asthma, COPD, GERD and others. This book illustrates the science behind our mucosal membranes: how they cause disease, how they can become damaged, and what we can do to repair them and keep them healthy.
Regulation of Gastrointestinal Mucosal Growth
Author: Rao N. Jaladanki
Publisher: Biota Publishing
ISBN: 1615047352
Category : Medical
Languages : en
Pages : 150
Book Description
The mammalian gastrointestinal mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. The control of the growth of gastrointestinal mucosa is unique and, compared with most other tissue in the body, complex. Mucosal growth is regulated by the same hormones that alter metabolism in other tissues, but the gastrointestinal mucosa also responds to host events triggered by the ingestion and presence of food within the digestive tract. These gut hormones and peptides regulate the growth of the exocrine pancreas, gallbladder epithelium, and the mucosa of the oxyntic gland region of the stomach and the small and large intestines. Luminal factors, including nutrients or other dietary factors, secretions, and microbes that occur within the lumen and distribute over a proximal-to-distal gradient, are also crucial for maintenance of normal gut mucosal regeneration and could explain the villous-height-crypt-depth gradient and variety of adaptation, since these factors are diluted, absorbed, and destroyed as they pass down the digestive tract. Recently, intestinal stem cells, cellular polyamines, and noncoding RNAs are shown to play an important role in the regulation of gastrointestinal mucosal growth under physiological and various pathological conditions. In this book, we highlight key issues and factors that control gastrointestinal mucosal growth and homeostasis, with special emphasis on the mechanisms through which epithelial renewal and apoptosis are regulated at the cellular and molecular levels.
Publisher: Biota Publishing
ISBN: 1615047352
Category : Medical
Languages : en
Pages : 150
Book Description
The mammalian gastrointestinal mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. The control of the growth of gastrointestinal mucosa is unique and, compared with most other tissue in the body, complex. Mucosal growth is regulated by the same hormones that alter metabolism in other tissues, but the gastrointestinal mucosa also responds to host events triggered by the ingestion and presence of food within the digestive tract. These gut hormones and peptides regulate the growth of the exocrine pancreas, gallbladder epithelium, and the mucosa of the oxyntic gland region of the stomach and the small and large intestines. Luminal factors, including nutrients or other dietary factors, secretions, and microbes that occur within the lumen and distribute over a proximal-to-distal gradient, are also crucial for maintenance of normal gut mucosal regeneration and could explain the villous-height-crypt-depth gradient and variety of adaptation, since these factors are diluted, absorbed, and destroyed as they pass down the digestive tract. Recently, intestinal stem cells, cellular polyamines, and noncoding RNAs are shown to play an important role in the regulation of gastrointestinal mucosal growth under physiological and various pathological conditions. In this book, we highlight key issues and factors that control gastrointestinal mucosal growth and homeostasis, with special emphasis on the mechanisms through which epithelial renewal and apoptosis are regulated at the cellular and molecular levels.
Mucosal Health in Aquaculture
Author: Benjamin H. Beck
Publisher: Academic Press
ISBN: 0124171931
Category : Technology & Engineering
Languages : en
Pages : 410
Book Description
Mucosal Health in Aquaculture is an essential reference on mucosal health for the diverse aquaculture community. Rich in explanatory figures and schematics, the book includes important concepts such as structural and cellular composition of mucosal surfaces in fish and shellfish, known functional roles of molecular and cellular actors during pathogen invasion, impacts of nutrition on the mucosal barriers, impacts of chemical treatments on mucosal surfaces, mucosal vaccines and vaccination strategies, and more. The health of cultured aquaculture species is critical in establishing the sustainable growth of the aquaculture industry worldwide, and mucosal health is of particular interest to those working in aquaculture because mucosal surfaces (skin, gill, intestine, reproductive tissues) constitute the first line of defense against pathogen invasion. Mucosal Health in Aquaculture captures the latest research on mucosal barriers in aquaculture species and their impacts on nutrition and immunity to ensure sustainable aquaculture development. - Includes research case studies to exhibit the importance of various integrated approaches to mucosal health - Examines the latest scientific methods and technologies to maximize efficiencies for healthy fish production for farming - Brings together the latest knowledge and research on mucosal barriers and mechanisms from world-wide experts in mucosal health - Utilizes detailed diagrams and figures to enhance comprehension
Publisher: Academic Press
ISBN: 0124171931
Category : Technology & Engineering
Languages : en
Pages : 410
Book Description
Mucosal Health in Aquaculture is an essential reference on mucosal health for the diverse aquaculture community. Rich in explanatory figures and schematics, the book includes important concepts such as structural and cellular composition of mucosal surfaces in fish and shellfish, known functional roles of molecular and cellular actors during pathogen invasion, impacts of nutrition on the mucosal barriers, impacts of chemical treatments on mucosal surfaces, mucosal vaccines and vaccination strategies, and more. The health of cultured aquaculture species is critical in establishing the sustainable growth of the aquaculture industry worldwide, and mucosal health is of particular interest to those working in aquaculture because mucosal surfaces (skin, gill, intestine, reproductive tissues) constitute the first line of defense against pathogen invasion. Mucosal Health in Aquaculture captures the latest research on mucosal barriers in aquaculture species and their impacts on nutrition and immunity to ensure sustainable aquaculture development. - Includes research case studies to exhibit the importance of various integrated approaches to mucosal health - Examines the latest scientific methods and technologies to maximize efficiencies for healthy fish production for farming - Brings together the latest knowledge and research on mucosal barriers and mechanisms from world-wide experts in mucosal health - Utilizes detailed diagrams and figures to enhance comprehension
Topical Applications and the Mucosa
Author: C. Surber
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805596162
Category : Medical
Languages : en
Pages : 174
Book Description
Mucosal membranes have unique anatomical and physiological properties -- differing from those of the keratinized epithelium -- which affect drug or chemical absorption. This makes the diagnosis and treatment of diseases of the mucosa a challenge to dermatologists as well as gynecologists, since many conditions are difficult to recognize and well-established principles of skin disease treatment do not apply to the mucosa. This volume is exclusively devoted to the mucosal membrane and delivers a better understanding of this distinctive area. Subsequently to introductory chapters on the morphology and physiology of the mucosa, the topical treatment of impaired mucosal membranes is discussed. A third section covers the wide spectrum of consumer products applied on mucosal surfaces. Finally, the safety of products for mucosal membranes is reviewed.Providing an excellent summary and review of the latest findings and topical applications, this book will be of great value to physicians and clinicians in dermatology or gynecology, pharmacists, scientists and toxicologists who are involved in the development of products for mucosal membranes.
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805596162
Category : Medical
Languages : en
Pages : 174
Book Description
Mucosal membranes have unique anatomical and physiological properties -- differing from those of the keratinized epithelium -- which affect drug or chemical absorption. This makes the diagnosis and treatment of diseases of the mucosa a challenge to dermatologists as well as gynecologists, since many conditions are difficult to recognize and well-established principles of skin disease treatment do not apply to the mucosa. This volume is exclusively devoted to the mucosal membrane and delivers a better understanding of this distinctive area. Subsequently to introductory chapters on the morphology and physiology of the mucosa, the topical treatment of impaired mucosal membranes is discussed. A third section covers the wide spectrum of consumer products applied on mucosal surfaces. Finally, the safety of products for mucosal membranes is reviewed.Providing an excellent summary and review of the latest findings and topical applications, this book will be of great value to physicians and clinicians in dermatology or gynecology, pharmacists, scientists and toxicologists who are involved in the development of products for mucosal membranes.
Mucosal Vaccines
Author: Hiroshi Kiyono
Publisher: Elsevier
ISBN: 0080537057
Category : Medical
Languages : en
Pages : 501
Book Description
This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. - Provides the latest views on mucosal vaccines - Applies basic principles to the development of new vaccines - Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases - Unique and user-friendly organization
Publisher: Elsevier
ISBN: 0080537057
Category : Medical
Languages : en
Pages : 501
Book Description
This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. - Provides the latest views on mucosal vaccines - Applies basic principles to the development of new vaccines - Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases - Unique and user-friendly organization
Common Clinical Presentations in Dogs and Cats
Author: Ryane E. Englar
Publisher: John Wiley & Sons
ISBN: 1119414601
Category : Medical
Languages : de
Pages : 2349
Book Description
Common Clinical Presentations in Dogs and Cats ist ein verlässliches Referenzwerk zum schnellen Nachschlagen der wichtigsten Informationen, um Erkrankungen bei Hunden und Katzen zu diagnostizieren. Häufige klinische Zustände lassen sich anhand des problemorientierten Ansatzes erkennen. Diagnose und Behandlungspläne werden eingeführt. Das Buch ist sowohl für Studenten der Veterinärmedizin als auch Kliniker ein nützliches Nachschlagewerk mit 78 Kapiteln, die die verschiedenen Körpersysteme beschreiben. Jedes Kapitel konzentriert sich auf die Hauptbeschwerden, erläutert mögliche Diagnosen und bestimmt den klinischen Pflegeansatz. Eine Fülle von Illustrationen, klinischen Fotos und Zeichnungen veranschaulichen die präsentierten Konzepte. Common Clinical Presentations in Dogs and Cats ist ein wichtiges Referenzwerk mit den folgenden Merkmalen: - Kliniker erhalten schnellen Zugriff auf Detailinformatione, um gängige Erkrankungen bei Hunden und Katzen zu erkennen und korrekt zu diagnostizieren. - Präsentiert die Informationen nach den jeweiligen klinischen Anzeichen und zu dem entsprechenden Körpersystem. - Alle Kapitel sind einheitlich aufgebaut und ermöglichen so das schnelle Nachschlagen. - Beinhaltet Farbfotos und Zeichnungen zur Veranschaulichung der Symptome. Common Clinical Presentations in Dogs and Cats richtet sich an Veterinärmediziner für Kleintiere und Studenten der Veterinärmedizin, ist als Referenzwerk für die Praxis konzipiert und vermittelt das notwendige Fachwissen, um eine Vielzahl von Erkrankungen verlässlich zu diagnostizieren.
Publisher: John Wiley & Sons
ISBN: 1119414601
Category : Medical
Languages : de
Pages : 2349
Book Description
Common Clinical Presentations in Dogs and Cats ist ein verlässliches Referenzwerk zum schnellen Nachschlagen der wichtigsten Informationen, um Erkrankungen bei Hunden und Katzen zu diagnostizieren. Häufige klinische Zustände lassen sich anhand des problemorientierten Ansatzes erkennen. Diagnose und Behandlungspläne werden eingeführt. Das Buch ist sowohl für Studenten der Veterinärmedizin als auch Kliniker ein nützliches Nachschlagewerk mit 78 Kapiteln, die die verschiedenen Körpersysteme beschreiben. Jedes Kapitel konzentriert sich auf die Hauptbeschwerden, erläutert mögliche Diagnosen und bestimmt den klinischen Pflegeansatz. Eine Fülle von Illustrationen, klinischen Fotos und Zeichnungen veranschaulichen die präsentierten Konzepte. Common Clinical Presentations in Dogs and Cats ist ein wichtiges Referenzwerk mit den folgenden Merkmalen: - Kliniker erhalten schnellen Zugriff auf Detailinformatione, um gängige Erkrankungen bei Hunden und Katzen zu erkennen und korrekt zu diagnostizieren. - Präsentiert die Informationen nach den jeweiligen klinischen Anzeichen und zu dem entsprechenden Körpersystem. - Alle Kapitel sind einheitlich aufgebaut und ermöglichen so das schnelle Nachschlagen. - Beinhaltet Farbfotos und Zeichnungen zur Veranschaulichung der Symptome. Common Clinical Presentations in Dogs and Cats richtet sich an Veterinärmediziner für Kleintiere und Studenten der Veterinärmedizin, ist als Referenzwerk für die Praxis konzipiert und vermittelt das notwendige Fachwissen, um eine Vielzahl von Erkrankungen verlässlich zu diagnostizieren.
Human Oral Mucosa
Author: Christopher Squier
Publisher: John Wiley & Sons
ISBN: 0470959738
Category : Medical
Languages : en
Pages : 151
Book Description
Human Oral Mucosa: Development, Structure and Function is a new text that reflects the considerable increase in knowledge of oral mucosa that has occurred in recent years. Our understanding of the structure of oral mucosa is now established at a molecular rather than a tissue or cellular level. This in turn has revealed a level of function that was previously not suspected, including a sophisticated barrier to the penetration of exogenous materials, and the synthesis of specific antimicrobial compounds, representing components of the innate immune system. There is also a growing realization of commonality in structure and function between regions of oral mucosa and the mucosae of the esophagus and vagina. The aim of the present volume is to provide a more sophisticated text on human oral mucosa than presently exists in textbooks and to bring together information that is otherwise to be found in separate, specialist volumes into a comprehensive text. It relates structure at the molecular, cellular and tissue level to function and to clinical behavior. The volume is directed to advanced students and researchers in oral biology, as well as those in allied areas of investigation, such as dermatology, gynecology, internal medicine and pathology.
Publisher: John Wiley & Sons
ISBN: 0470959738
Category : Medical
Languages : en
Pages : 151
Book Description
Human Oral Mucosa: Development, Structure and Function is a new text that reflects the considerable increase in knowledge of oral mucosa that has occurred in recent years. Our understanding of the structure of oral mucosa is now established at a molecular rather than a tissue or cellular level. This in turn has revealed a level of function that was previously not suspected, including a sophisticated barrier to the penetration of exogenous materials, and the synthesis of specific antimicrobial compounds, representing components of the innate immune system. There is also a growing realization of commonality in structure and function between regions of oral mucosa and the mucosae of the esophagus and vagina. The aim of the present volume is to provide a more sophisticated text on human oral mucosa than presently exists in textbooks and to bring together information that is otherwise to be found in separate, specialist volumes into a comprehensive text. It relates structure at the molecular, cellular and tissue level to function and to clinical behavior. The volume is directed to advanced students and researchers in oral biology, as well as those in allied areas of investigation, such as dermatology, gynecology, internal medicine and pathology.
The Gastrointestinal Circulation
Author: Peter R. Kvietys
Publisher: Morgan & Claypool Publishers
ISBN: 1615041176
Category : Medical
Languages : en
Pages : 127
Book Description
The microcirculation of the gastrointestinal tract is under the control of both myogenic and metabolic regulatory systems. The myogenic mechanism contributes to basal vascular tone and the regulation of transmural pressure, while the metabolic mechanism is responsible for maintaining an appropriate balance between O2 demand and O2 delivery. In the postprandial state, hydrolytic products of food digestion elicit a hyperemia, which serves to meet the increased O2 demand of nutrient assimilation. Metabolically linked factors (e.g., tissue pO2, adenosine) are primarily responsible for this functional hyperemia. The fenestrated capillaries of the gastrointestinal mucosa are relatively permeable to small hydrolytic products of food digestion (e.g., glucose), yet restrict the transcapillary movement of larger molecules (e.g., albumin). This allows for the absorption of hydrolytic products of food digestion without compromising the oncotic pressure gradient governing transcapillary fluid movement and edema formation. The gastrointestinal microcirculation is also an important component of the mucosal defense system whose function is to prevent (and rapidly repair) inadvertent epithelial injury by potentially noxious constituents of chyme. Two pathological conditions in which the gastrointestinal circulation plays an important role are ischemia/reperfusion and chronic portal hypertension. Ischemia/reperfusion results in mucosal edema and disruption of the epithelium due, in part, to an inflammatory response (e.g., increase in capillary permeability to macromolecules and neutrophil infiltration). Chronic portal hypertension results in an increase in gastrointestinal blood flow due to an imbalance in vasodilator and vasoconstrictor influences on the microcirculation. Table of Contents: Introduction / Anatomy / Regulation of Vascular Tone and Oxygenation / Extrinsic Vasoregulation: Neural and Humoral / Postprandial Hyperemia / Transcapillary Solute Exchange / Transcapillary Fluid Exchange / Interaction of Capillary and Interstitial Forces / Gastrointestinal Circulation and Mucosal Defense / Gastrointestinal Circulation and Mucosal Pathology I: Ischemia/Reperfusion / Gastrointestinal Circulation and Mucosal Pathology II: Chronic Portal Hypertension / Summary and Conclusions / References / Author Biography
Publisher: Morgan & Claypool Publishers
ISBN: 1615041176
Category : Medical
Languages : en
Pages : 127
Book Description
The microcirculation of the gastrointestinal tract is under the control of both myogenic and metabolic regulatory systems. The myogenic mechanism contributes to basal vascular tone and the regulation of transmural pressure, while the metabolic mechanism is responsible for maintaining an appropriate balance between O2 demand and O2 delivery. In the postprandial state, hydrolytic products of food digestion elicit a hyperemia, which serves to meet the increased O2 demand of nutrient assimilation. Metabolically linked factors (e.g., tissue pO2, adenosine) are primarily responsible for this functional hyperemia. The fenestrated capillaries of the gastrointestinal mucosa are relatively permeable to small hydrolytic products of food digestion (e.g., glucose), yet restrict the transcapillary movement of larger molecules (e.g., albumin). This allows for the absorption of hydrolytic products of food digestion without compromising the oncotic pressure gradient governing transcapillary fluid movement and edema formation. The gastrointestinal microcirculation is also an important component of the mucosal defense system whose function is to prevent (and rapidly repair) inadvertent epithelial injury by potentially noxious constituents of chyme. Two pathological conditions in which the gastrointestinal circulation plays an important role are ischemia/reperfusion and chronic portal hypertension. Ischemia/reperfusion results in mucosal edema and disruption of the epithelium due, in part, to an inflammatory response (e.g., increase in capillary permeability to macromolecules and neutrophil infiltration). Chronic portal hypertension results in an increase in gastrointestinal blood flow due to an imbalance in vasodilator and vasoconstrictor influences on the microcirculation. Table of Contents: Introduction / Anatomy / Regulation of Vascular Tone and Oxygenation / Extrinsic Vasoregulation: Neural and Humoral / Postprandial Hyperemia / Transcapillary Solute Exchange / Transcapillary Fluid Exchange / Interaction of Capillary and Interstitial Forces / Gastrointestinal Circulation and Mucosal Defense / Gastrointestinal Circulation and Mucosal Pathology I: Ischemia/Reperfusion / Gastrointestinal Circulation and Mucosal Pathology II: Chronic Portal Hypertension / Summary and Conclusions / References / Author Biography
Oral Mucosa in Health and Disease
Author: Lesley Ann Bergmeier
Publisher: Springer
ISBN: 9783319560649
Category : Medical
Languages : en
Pages : 0
Book Description
This book is designed to re-establish the position of the oral cavity and its mucosa at the forefront of defence and maintenance of homeostatic mechanisms that protect against disease not just locally but also systemically. The oral mucosa is a unique collection of tissues that constitutes a highly active environment with its own unique microflora and homeostatic interaction with the innate and adaptive immune responses. As an immune tissue the oral mucosa was somewhat neglected in the past owing to the tendency to assume similarity to the gut mucosa. More recently it has become apparent that the oral mucosa is a complex environment and, like the esophageal mucosa, has more in common with vaginal tissue than with the gut. Furthermore, the ability of the oral mucosa to act as an immune inductive site has made it an attractive area of research in terms of desensitization for allergic reactions and possibly autoimmune responses. In this book, recognized experts in the field provide up-to-date coverage of all aspects of the structure and function of the oral mucosa, reflecting important recent advances in knowledge, including at the molecular level.
Publisher: Springer
ISBN: 9783319560649
Category : Medical
Languages : en
Pages : 0
Book Description
This book is designed to re-establish the position of the oral cavity and its mucosa at the forefront of defence and maintenance of homeostatic mechanisms that protect against disease not just locally but also systemically. The oral mucosa is a unique collection of tissues that constitutes a highly active environment with its own unique microflora and homeostatic interaction with the innate and adaptive immune responses. As an immune tissue the oral mucosa was somewhat neglected in the past owing to the tendency to assume similarity to the gut mucosa. More recently it has become apparent that the oral mucosa is a complex environment and, like the esophageal mucosa, has more in common with vaginal tissue than with the gut. Furthermore, the ability of the oral mucosa to act as an immune inductive site has made it an attractive area of research in terms of desensitization for allergic reactions and possibly autoimmune responses. In this book, recognized experts in the field provide up-to-date coverage of all aspects of the structure and function of the oral mucosa, reflecting important recent advances in knowledge, including at the molecular level.
Diagnosis and Treatment in Internal Medicine
Author: Patrick Davey
Publisher: Oxford University Press
ISBN: 019956874X
Category : Medical
Languages : en
Pages : 1297
Book Description
Diagnosis and Treatment in Internal Medicine equips trainee doctors with the essential skills and core knowledge to establish a diagnosis reliably and quickly, before outlining the management of the clinical condition diagnosed. Organised into three sections, the first provides a vital overview, whilst the second focuses on common presentations and diagnoses. Uniquely, this new book shows readers how to turn symptoms into a list of diagnoses ordered by probability - a differential diagnosis. Experienced consultants who teach trainees every day demonstrate how to derive an ordered differential diagnosis, how to narrow this down to a single diagnosis and if not, how to live with diagnostic uncertainty. The final section provides a comprehensive account of the management of system-based syndromes and diseases. Highly-structured chapters emphasize how common conditions present, how to approach a diagnosis, and how to estimate prognosis, treatment and its effectiveness. An onus is placed on the development of crucial diagnostic skills and the ability to devise evidence-based management plans quickly and accurately, making this an ideal text for core medical trainees.
Publisher: Oxford University Press
ISBN: 019956874X
Category : Medical
Languages : en
Pages : 1297
Book Description
Diagnosis and Treatment in Internal Medicine equips trainee doctors with the essential skills and core knowledge to establish a diagnosis reliably and quickly, before outlining the management of the clinical condition diagnosed. Organised into three sections, the first provides a vital overview, whilst the second focuses on common presentations and diagnoses. Uniquely, this new book shows readers how to turn symptoms into a list of diagnoses ordered by probability - a differential diagnosis. Experienced consultants who teach trainees every day demonstrate how to derive an ordered differential diagnosis, how to narrow this down to a single diagnosis and if not, how to live with diagnostic uncertainty. The final section provides a comprehensive account of the management of system-based syndromes and diseases. Highly-structured chapters emphasize how common conditions present, how to approach a diagnosis, and how to estimate prognosis, treatment and its effectiveness. An onus is placed on the development of crucial diagnostic skills and the ability to devise evidence-based management plans quickly and accurately, making this an ideal text for core medical trainees.