Morphogens in the Wiring of the Nervous System

Morphogens in the Wiring of the Nervous System PDF Author: Juan Pablo Henríquez
Publisher: Frontiers Media SA
ISBN: 2832547818
Category : Science
Languages : en
Pages : 232

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Book Description
Neuronal function relies on the establishment of proper connections between neurons and their target cells during development. This basic statement involves several cellular processes, such as neuronal differentiation, the polarized outgrowth of axons and dendrites from differentiated neurons, and the pathfinding of axons towards target cells. The subsequent recognition of complementary synaptic partners finally triggers the formation, maturation, and maintenance of functional synapses. Morphogens are secreted signaling molecules that regulate tissue patterning and cell identity during early embryonic development. Remarkably, growing evidence over the last years arising from different invertebrate and vertebrate model organisms has shown that, after cell fate has been established, morphogens also control the precise wiring of the nervous system.

Morphogens in the Wiring of the Nervous System

Morphogens in the Wiring of the Nervous System PDF Author: Juan Pablo Henríquez
Publisher: Frontiers Media SA
ISBN: 2832547818
Category : Science
Languages : en
Pages : 232

Get Book Here

Book Description
Neuronal function relies on the establishment of proper connections between neurons and their target cells during development. This basic statement involves several cellular processes, such as neuronal differentiation, the polarized outgrowth of axons and dendrites from differentiated neurons, and the pathfinding of axons towards target cells. The subsequent recognition of complementary synaptic partners finally triggers the formation, maturation, and maintenance of functional synapses. Morphogens are secreted signaling molecules that regulate tissue patterning and cell identity during early embryonic development. Remarkably, growing evidence over the last years arising from different invertebrate and vertebrate model organisms has shown that, after cell fate has been established, morphogens also control the precise wiring of the nervous system.

Encyclopedia of Neuroscience, Volume 1

Encyclopedia of Neuroscience, Volume 1 PDF Author: Larry R. Squire
Publisher: Academic Press
ISBN: 0080963935
Category : Medical
Languages : en
Pages : 12505

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Book Description
The Encyclopedia of the Neuroscience explores all areas of the discipline in its focused entries on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. Each article is written by an expert in that specific domain and peer reviewed by the advisory board before acceptance into the encyclopedia. Each article contains a glossary, introduction, a reference section, and cross-references to other related encyclopedia articles. Written at a level suitable for university undergraduates, the breadth and depth of coverage will appeal beyond undergraduates to professionals and academics in related fields.

Molecular Biology of the Cell

Molecular Biology of the Cell PDF Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0

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Book Description


Developmental Neurobiology

Developmental Neurobiology PDF Author: Greg Lemke
Publisher: Academic Press
ISBN: 0123751675
Category : Science
Languages : en
Pages : 771

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Book Description
Developmental Neuroscience is one of the six core disciplines in Neuroscience, and yet no single volume, non-textbook reference exists on the market that provides researchers with more in-depth, high-level information on developmental neurobiology. Currently, anyone interested in the field at a higher level must sift through review articles published frequently and the more specific handbooks that focus on aspects of development rather than the field as a whole. This reference is the first of its kind to fill this need. It pulls together the relevant articles on the topic from the 10-volume Encyclopedia of Neuroscience (Academic Press, 2008) and serves as an affordable and immediate resource for scientists, postdocs, graduate students with an interest beyond the basic textbook materials on the subject. - The first and only comprehensive, single-volume reference for developmental neuroscience that goes beyond the basic textbook information - The 93 chapters cover topics ranging from cell fate determination, path finding, synapse generation, neural stem cells, to neurodegeneration and regeneration, carefully selected from the Encyclopedia of Neuroscience by one of the great developmental neuroscientists, Greg Lemke - The best researchers in the field provide their conclusions in the context of the latest experimental results

The Central Nervous System

The Central Nervous System PDF Author: Per Brodal
Publisher: Oxford University Press
ISBN: 0190251492
Category : Medical
Languages : en
Pages : 608

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Book Description
The Central Nervous System: Structure and Function, Fourth Edition continues the tradition of one of the most respected textbooks in clinical neuroscience by providing medical students the knowledge and understanding of neuroscience as a basis for clinical thinking. While remaining concise and easy to read, the text encourages reflection and critical thinking of established facts and scientific conjecture and will be of interest to medical, graduate, and undergraduate students alike. Prof Per Brodal provides clear descriptions of brain structures and relates them to their functional properties by incorporating data from molecular biology to clinical neurology. The numerous full color line drawings - based on the author's long experience of teaching undergraduate students and new to this edition - make it easier to understand complex structural and functional relationships. Thoroughly revised, this fourth edition goes further in integrating material from all fields of the neurosciences. Now divided into 8 Sections with a total of 34 Chapters, each chapter is introduced by a brief overview of what the student can expect to learn. New material has been incorporated in all chapters while maintaining the scope and coverage that has established The Central Nervous System: Structure and Function as the preeminent neuroscience textbook.

Wiring the Nervous System: Mechanisms of Axonal and Dendritic Remodelling in Health and Disease

Wiring the Nervous System: Mechanisms of Axonal and Dendritic Remodelling in Health and Disease PDF Author: Tracy S. Tran
Publisher: CRC Press
ISBN: 1003812228
Category : Science
Languages : en
Pages : 328

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Book Description
This book examines recent key findings on the mechanisms of axonal and dendritic remodeling in different model organisms. Each chapter is contributed by a panel of experts in their respective subfields of neurosciences, to provide and discuss the latest discoveries ranging from neuronal morphogenesis during development, experience-dependent structural plasticity, to neuronal degeneration, regeneration, and pathologies in neurological disorders. The process of neuronal remodeling, specifically their axons and dendrites, is essential for the proper wiring of the nervous system during early development and continues during postnatal ages to shape the pattern of synaptic connections throughout the life of the organism, including humans. Over recent years, substantial progress has been made in our understanding of the cellular and molecular mechanisms that control neuronal remodeling. In addition, there is accumulating evidence demonstrating how the nervous system could remodel in response to injury and in pathological conditions. Topics discussed in the book include: Axonal degeneration during development and in pathological or disease conditions Neuronal morphogenesis (axons and dendrites) Experience-dependent structural plasticity to synaptogenesis Dendrite degeneration and regeneration

Principles of Neurobiology

Principles of Neurobiology PDF Author: Liqun Luo
Publisher: Garland Science
ISBN: 1000096807
Category : Science
Languages : en
Pages : 761

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Book Description
Principles of Neurobiology, Second Edition presents the major concepts of neuroscience with an emphasis on how we know what we know. The text is organized around a series of key experiments to illustrate how scientific progress is made and helps upper-level undergraduate and graduate students discover the relevant primary literature. Written by a single author in a clear and consistent writing style, each topic builds in complexity from electrophysiology to molecular genetics to systems level in a highly integrative approach. Students can fully engage with the content via thematically linked chapters and will be able to read the book in its entirety in a semester-long course. Principles of Neurobiology is accompanied by a rich package of online student and instructor resources including animations, figures in PowerPoint, and a Question Bank for adopting instructors.

Axon Growth and Guidance

Axon Growth and Guidance PDF Author: Dominique Bagnard
Publisher: Springer Science & Business Media
ISBN: 0387767150
Category : Medical
Languages : en
Pages : 184

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Book Description
This book proposes an updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. The introductory chapter will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring.

Molecular Mechanisms of Neural Development and Insights into Disease

Molecular Mechanisms of Neural Development and Insights into Disease PDF Author:
Publisher: Academic Press
ISBN: 0128152826
Category : Science
Languages : en
Pages : 548

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Book Description
Neural Development and Disease, Volume 142 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters by one or more members of an international board of authors. Sections in this new release cover The role of primary cilia in neural development and disease, Mechanisms of axon guidance receptor regulation and signaling, Synaptic recognition molecules in development and disease, The regulation of cortical neurogenesis, Axon guidance in the developing spinal cord, The role of astrocytes in synapse formation and maturation, Development of motor circuits, Molecular mechanisms that mediate dendrite morphogenesis, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Current Topics in Developmental Biology series

Cellular Migration and Formation of Neuronal Connections

Cellular Migration and Formation of Neuronal Connections PDF Author:
Publisher: Academic Press
ISBN: 0123973473
Category : Science
Languages : en
Pages : 1081

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Book Description
The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns. - Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop - Features leading experts in various subfields as Section Editors and article Authors - All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship - Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity