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Author: Stavros Kromidas
Publisher: John Wiley & Sons
ISBN: 3527612319
Category : Science
Languages : en
Pages : 309
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Book Description
A unique approach to solving HPLC problems. Everyone who bought "Problem Solving in HPLC" by Stavros Kromidas will equally benefit from nearly 100 new practical examples for optimization, trouble-shooting, and instrument performance given in this sequel. The author provides - guidance for selecting and evaluating methods, intstruments and columns, - practical help with everyday trouble-shooting, - advice for optimizing separations, always explaining the reason why. In each case the problem, the solution and the conclusions are presented over a maximum of 4 pages, and in addition the book contains manufacturers' addresses, references, data tables and checklists.
Author: Stavros Kromidas
Publisher: John Wiley & Sons
ISBN: 3527612319
Category : Science
Languages : en
Pages : 309
Get Book Here
Book Description
A unique approach to solving HPLC problems. Everyone who bought "Problem Solving in HPLC" by Stavros Kromidas will equally benefit from nearly 100 new practical examples for optimization, trouble-shooting, and instrument performance given in this sequel. The author provides - guidance for selecting and evaluating methods, intstruments and columns, - practical help with everyday trouble-shooting, - advice for optimizing separations, always explaining the reason why. In each case the problem, the solution and the conclusions are presented over a maximum of 4 pages, and in addition the book contains manufacturers' addresses, references, data tables and checklists.
Author: Veronika R. Meyer
Publisher: John Wiley & Sons
ISBN: 3527659129
Category : Science
Languages : en
Pages : 195
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Book Description
The third edition of this popular problem-solving guide for this widely-used method includes eleven completely new examples and several updated ones, adding up to 100 contributions about pitfalls and errors in HPLC. Each example is presented on a double page with the text on the left-hand and a fi gure on the right-hand side, true to the motto 'a picture says more than a thousand words'. In addition, the author presents essential fundamentals as well as helpful strategies, such as equipment tests or quality assurance processes. New in this edition * Variability of the standard deviation * Infl uence of the acid type and concentration in the eluent * Water as an unintentional additive in the mobile phase * Inadequate purity of mobile phase water * Incomplete degassing * Inadequate stabilization of the extraction solvent * Tailing of phosphate compounds in the presence of steel * Different detection properties of diastereomers * Detector overload in ELSD * System suitability test * From repeatability to reproducibility A must-have resource for all users - showing how to use HPLC efficiently and obtain reliable results.
Author: Stavros Kromidas
Publisher: John Wiley & Sons
ISBN: 3527611991
Category : Science
Languages : en
Pages : 786
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Book Description
The only topical HPLC book to focus on optimization, this volume addresses the needs of HPLC users who wish to constantly improve their methods, in particular in terms of throughput, accuracy and cost-effectiveness. This handbook features contributions from such bestselling authors as John W. Dolan, Michael McBrien, Veronika R. Meyer, Uwe D. Neue, Lloyd R. Snyder, and Klaus K. Unger, as well as from scientists working for major companies, including Agilent, AstraZeneca, Merck, Schering, Tosoh Biosep, VWR, and Waters. It covers essential aspects of optimization in general, optimization in different LC-modi, hyphenated techniques and computer-aided optimization. The whole is rounded off with a section of user reports.
Author: Serban C. Moldoveanu
Publisher: Newnes
ISBN: 0123850134
Category : Science
Languages : en
Pages : 550
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Book Description
This book discusses in a systematic manner the role of separation in HPLC, the types and characteristics of stationary phases and of mobile phases used in this technique, as well as other factors influencing the separation. The selection process of stationary and mobile phase for a specific separation is described as related to the physico-chemical characteristics of the molecules to be separated and of their matrix. All these subjects are discussed from the point of view of the new developments in HPLC. The book also includes a part presenting the practice of modern HPLC as necessary for applications, particularly related to the analysis of pharmaceutical and biological samples, food and beverages, environmental samples, etc. Gives a clear presentation of notions and conceptsDiscusses key parameters in HPLC separationIncludes modern developments in HPLCDescribes interrelation between various HPLC features (solvent pressure, separation, detection)Includes a large number of references.
Author: Sergio Petrozzi
Publisher: John Wiley & Sons
ISBN: 3527665919
Category : Science
Languages : en
Pages : 388
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Book Description
This practical book in instrumental analytics conveys an overview of important methods of analysis and enables the reader to realistically learn the (principally technology-independent) working techniques the analytical chemist uses to develop methods and conduct validation. What is to be conveyed to the student is the fact that analysts in their capacity as problem-solvers perform services for certain groups of customers, i.e., the solution to the problem should in any case be processed in such a way as to be "fit for purpose". The book presents sixteen experiments in analytical chemistry laboratory courses. They consist of the classical curriculum used at universities and universities of applied sciences with chromatographic procedures, atom spectrometric methods, sensors and special methods (e.g. field flow fractionation, flow injection analysis and N-determination according to Kjeldahl). The carefully chosen combination of theoretical description of the methods of analysis and the detailed instructions given are what characterizes this book. The instructions to the experiments are so detailed that the measurements can, for the most part, be taken without the help of additional literature. The book is complemented with tips for effective literature and database research on the topics of organization and the practical workflow of experiments in analytical laboratory, on the topic of the use of laboratory logs as well as on writing technical reports and grading them (Evaluation Guidelines for Laboratory Experiments). A small introduction to Quality Management, a brief glance at the history of analytical chemistry as well as a detailed appendix on the topic of safety in analytical laboratories and a short introduction to the new system of grading and marking chemicals using the "Globally Harmonized System of Classification and Labelling of Chemicals (GHS)", round off this book. This book is therefore an indispensable workbook for students, internship assistants and lecturers (in the area of chemistry, biotechnology, food technology and environmental technology) in the basic training program of analytics at universities and universities of applied sciences.
Author: Satinder Ahuja
Publisher: Elsevier
ISBN: 0080455182
Category : Medical
Languages : en
Pages : 679
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Book Description
High pressure liquid chromatography–frequently called high performance liquid chromatography (HPLC or, LC) is the premier analytical technique in pharmaceutical analysis and is predominantly used in the pharmaceutical industry. Written by selected experts in their respective fields, the Handbook of Pharmaceutical Analysis by HPLC Volume 6, provides a complete yet concise reference guide for utilizing the versatility of HPLC in drug development and quality control. Highlighting novel approaches in HPLC and the latest developments in hyphenated techniques, the book captures the essence of major pharmaceutical applications (assays, stability testing, impurity testing, dissolution testing, cleaning validation, high-throughput screening). A complete reference guide to HPLC Describes best practices in HPLC and offers 'tricks of the trade' in HPLC operation and method development Reviews key HPLC pharmaceutical applications and highlights currents trends in HPLC ancillary techniques, sample preparations, and data handling
Author: Satinder Ahuja
Publisher: Elsevier
ISBN: 0080554199
Category : Medical
Languages : en
Pages : 533
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Book Description
High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective. HPLC Method Development for Pharmaceuticals is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge. - Covers the requirements for HPLC in a pharmaceutical setting including strategies for software and hardware validation to allow for use in a regulated laboratory - Provides an overview of the pharmaceutical development process (clinical phases, chemical and pharmaceutical development activities) - Discusses how HPLC is used in each phase of pharmaceutical development and how methods are developed to support activities in each phase
Author: Chunlong Zhang
Publisher: John Wiley & Sons
ISBN: 1119778565
Category : Science
Languages : en
Pages : 581
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Book Description
Fundamentals of Environmental Sampling and Analysis A fully reworked and updated introduction to the fundamentals and applications of environmental sampling and analysis Environmental sampling and analysis are essential components of environmental data acquisition and scientific research. The acquisition of reliable data with respect to proper sampling, chemical and instrumental methodology, and QA/QC is a critical precursor to all environmental work. No would-be environmental scientist, engineer, or policymaker can succeed without an understanding of how to correctly acquire, assess and use credible data. Fundamentals of Environmental Sampling and Analysis, 2nd edition provides this understanding, with a comprehensive survey of the theory and applications of these critical sampling and analytical tools. The field of environmental research has expanded greatly since the publication of the first edition, and this book has been completely rewritten to reflect the latest studies and technological developments. The resulting mix of theory and practice will continue to serve as the standard introduction to the subject. Readers of the second edition of Fundamentals of Environmental Sampling and Analysis will also find: Three new chapters and numerous expanded sections on topics of emerging environmental concerns Detailed discussion of subjects including passive sampling, Raman spectroscopy, non-targeted mass spectroscopic analysis, and many more Over 500 sample problems and solutions along with other supplementary instructional materials Fundamentals of Environmental Sampling and Analysis is ideal for students of environmental science and engineering as well as professionals and regulators for whom reliable environmental data through sampling and analysis is critical.
Author: Carrillo-Cedillo, Eugenia Gabriela
Publisher: IGI Global
ISBN: 1799896153
Category : Technology & Engineering
Languages : en
Pages : 298
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Book Description
Quality control in pharmaceutical products and medical devices is vital for users as failing to comply with national and international regulations can lead to accidents that could easily be avoided. For this reason, manufacturing a quality medical product will support patient safety. Microbiologists working in both the pharmaceutical and medical device industries face considerable challenges in keeping abreast of the myriad microbiological references available to them and the continuously evolving regulatory requirements. Quality Control Applications in the Pharmaceutical and Medical Device Manufacturing Industry presents the importance of quality control in pharmaceutical products and medical devices, which must have very high-quality standards to not cause problems to the health of patients. It reinforces and updates the knowledge of analytical, instrumental, and biological methods to demonstrate the correct quality control and good manufacturing practice for pharmaceutical products and medical devices. Covering topics such as pharmaceutical nano systems, machine learning, and software validation, this book is an essential resource for managers, engineers, supervisors, pharmacists, chemists, academicians, and researchers.
Author: James W. Robinson
Publisher: CRC Press
ISBN: 1315301148
Category : Science
Languages : en
Pages : 920
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Book Description
Analytical chemistry today is almost entirely instrumental analytical chemistry and it is performed by many scientists and engineers who are not chemists. Analytical instrumentation is crucial to research in molecular biology, medicine, geology, food science, materials science, and many other fields. With the growing sophistication of laboratory equipment, there is a danger that analytical instruments can be regarded as "black boxes" by those using them. The well-known phrase "garbage in, garbage out" holds true for analytical instrumentation as well as computers. This book serves to provide users of analytical instrumentation with an understanding of their instruments. This book is written to teach undergraduate students and those working in chemical fields outside analytical chemistry how contemporary analytical instrumentation works, as well as its uses and limitations. Mathematics is kept to a minimum. No background in calculus, physics, or physical chemistry is required. The major fields of modern instrumentation are covered, including applications of each type of instrumental technique. Each chapter includes: A discussion of the fundamental principles underlying each technique Detailed descriptions of the instrumentation. An extensive and up to date bibliography End of chapter problems Suggested experiments appropriate to the technique where relevant This text uniquely combines instrumental analysis with organic spectral interpretation (IR, NMR, and MS). It provides detailed coverage of sampling, sample handling, sample storage, and sample preparation. In addition, the authors have included many instrument manufacturers’ websites, which contain extensive resources.
