Molecular Regulation of Germ Cell Number and Fate in the Nematode C. Elegans PDF Download
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Author: Liana B. Lamont
Publisher:
ISBN:
Category :
Languages : en
Pages : 174
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Book Description
Author: Liana B. Lamont
Publisher:
ISBN:
Category :
Languages : en
Pages : 174
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Book Description
Author: Tim Schedl
Publisher: Springer Science & Business Media
ISBN: 1461440157
Category : Medical
Languages : en
Pages : 434
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Book Description
Germ cells in sexually reproducing metazoa, through the germline lineage, are the route by which genetic material and cytoplasmic constituents are passed from one generation to the next in the continuum of life. Chapters in this book review germ cell development in the model organism Caenorhabditis elegans, discussing the biology, the genetics and the molecular mechanisms for various processes, as well as drawing comparisons with other organisms. Processes discussed include specification of germ cell fate, meiosis, gametogenesis, environmental/ physiological controls, epigenetics and translational control, fertilization and the oocyte-to-embryo transition. This book thus provides a comprehensive picture of the germline lineage and the continuum of life for the worm.
Author: Steven X. Hou
Publisher: Humana Press
ISBN: 9781617378805
Category : Science
Languages : en
Pages : 0
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Book Description
In this comprehensive and cutting-edge book, leading experts explore the parameters that define germline stem cells and the mechanisms that regulate the cell behavior in order to better isolate, characterize and maintain them. The volume begins by providing protocols for germline stem cell identification and regulation in model organisms, and concludes with detailed chapters covering current techniques involving in vitro culture and the applications of the cells.
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: Judith Ann Austin
Publisher:
ISBN:
Category :
Languages : en
Pages : 304
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Book Description
Author: Suk-Won Jin
Publisher:
ISBN:
Category :
Languages : en
Pages : 444
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Book Description
Author:
Publisher: Academic Press
ISBN: 0128161787
Category : Science
Languages : en
Pages : 452
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Book Description
Nematode Models of Development and Disease, Volume 144 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters surrounding Transgenerational inheritance, Oscillatory expression and function, Concepts and functions of small RNA pathways in C. elegans, Exploring the nuclear lamina in health and pathology using C. elegans, Cellular Plasticity, Morphogenesis, Tubulogenesis, Organogenesis forces, Programmed cell fusion in development and homeostasis, One template, two outcomes: how does the sex-shared nervous system generate sex-specific behaviors?, Metabolic Cellular Coordination of Gene-Environment Interactions, and much more. Other chapters cover Chemical and physical cues and micro-evolution in early embryogenesis, Innate immunity, Sex and Death, Dendrites maturation, axonal growth and extracellular glycoproteins, Autophagocytosis, Spermatogenesis, and the developmental and physiological roles of phagocytosis in Caenorhabditis elegans. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology
Author: SRIVALLI MAMILLAPALLI
Publisher:
ISBN:
Category :
Languages : en
Pages : 75
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Book Description
The precise regulation of germ cell fates (sperm or oocyte) lies at the heart of reproduction and fertility. The nematode Caenorhabditis elegans hermaphrodites produce a discrete number of sperm during larval development and then switch to produce oocyte during adulthood. A number of positive (e.g., fbf genes) and negative (e.g., gld-3) regulators are important for this switch. Here, we found that aberrant activation of MPK-1 (an ERK homolog) by removal of both fbf-1 and lip-1 partially inhibits sperm-oocyte switch, resulting in Mog (masculinization of germline) sterility. The fbf-1 gene encodes a conserved PUF (Pumilio and FBF) RNA-binding protein and the lip-1 gene encodes an MPK-1/ERK phosphatase. Notably, inhibition of MPK-1/ERK signaling by either genetic mutation or chemical inhibition reprograms the germ cell fate and thus helps in regaining the fertility. We also found that fbf-1; lip-1 Mog sterility was enhanced by the depletion of G2/M cell cycle regulators, including CYB-3/Cyclin B, CDK-1/CDK1, and CDC-25.1/CDC25. Markedly, cdc-25.1 mRNA is a direct target of FBF-1. These results suggest that FBF-1 and LIP-1 may promote sperm-oocyte switch by activating MPK-1/ERK signaling and G2/M cell cycle progression.
Author: Xiaoben Gao
Publisher:
ISBN:
Category :
Languages : en
Pages : 222
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Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 362
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Book Description
Germ cell sex determination is an ancient cell fate decision, but the molecular regulation of this fundamental decision is poorly understood. In the C. elegans germline, FOG-1 and FOG-3 are the terminal regulators of sperm fate. Here I explore sex determination on a genome wide scale in the C. elegans germline. First, I report on a new dataset of spermatogenic, oogenic, and gender neutral mRNAs in the germline. Second, I incorporate the sperm, oocyte, and maternal transcriptome datasets into this new dataset to characterize these transcripts into oogenic and spermatogenic mRNA programs. Third, I identify 81 FOG-1 associated mRNAs and 722 FOG-3 associated mRNAs. 76 of the FOG-1 associated mRNAs are also FOG-3 associated mRNAs and most of these mRNAs are oogenic program mRNAs. FOG-1 and FOG-3 also co-localize in the germline and co-immunoprecipitate suggesting that FOG-1 and FOG-3 work together. I propose a model in which FOG-1 and FOG-3 are in a complex repressing oogenic mRNAs to specify sperm fate.
