Molecular Epidemiology of Human Immunodeficiency Viruses and Exploration of Host Immune Responses Associated with Long-term Control of HIV-2 Infection in West Africa PDF Download
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Author: Thusan De Silva
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Author: Thusan De Silva
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Author: T. De Silva
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: King K. Holmes
Publisher: World Bank Publications
ISBN: 1464805253
Category : Medical
Languages : en
Pages : 1027
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Book Description
Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Author: Dean T. Jamison
Publisher: World Bank Publications
ISBN: 0821363980
Category : Medical
Languages : en
Pages : 414
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Book Description
Current data and trends in morbidity and mortality for the sub-Saharan Region as presented in this new edition reflect the heavy toll that HIV/AIDS has had on health indicators, leading to either a stalling or reversal of the gains made, not just for communicable disorders, but for cancers, as well as mental and neurological disorders.
Author: Emilio Emini
Publisher: Princeton University Press
ISBN: 9780691004549
Category : Medical
Languages : en
Pages : 550
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Book Description
The past few years have witnessed an explosive increase in our collective knowledge of the biology of the human immunodeficiency virus (HIV). Researchers have acquired new understanding of the virus's biochemistry, molecular biology, pathogenesis, genetics, and immunobiology. Resulting therapeutic advances have significantly prolonged the lives of thousands. Yet, the need to develop better therapies is ever more acute and--given the virus's continued spread through the human population--the need for an effective vaccine is urgent. These goals can be accomplished only through the experienced synthesis of information from the many disciplines participating in HIV research and through the insights of new investigators. This volume is designed to lower the barriers imposed on investigators by the sheer volume of available information--information that often can be found only in far-flung and specialized journals. It provides, in a single resource, an in-depth overview of the diverse areas that constitute HIV research. The result is a broad introduction for students and researchers new to the field as well as an integrated overview for researchers specialized in particular areas of HIV investigation. The volume will also benefit those seeking technical understanding of the virus's biology, including physicians treating HIV-infected patients. Each chapter is a comprehensive presentation of one area of current AIDS research--including work on the virus life cycle, epidemiology, genetics, protease and reverse transcriptase inhibitors, receptor and co-receptor interactions, therapeutic targets, clinical treatment, immunobiology, and vaccines--written by a leading researcher in that area. The contributors are Jon P. Anderson, Jan Balzarini, Elana Cherry, Thomas J. Coates, Chris Collins, Jon H. Condra, Mark B. Feinberg, Richard B. Gaynor, Matthias Götte, Daria J. Hazuda, Spyros Kalams, Nathaniel R. Landau, Gerald H. Learn, Norman L. Letvin, James I. Mullins, Willscott E. Naugler, David Nickle, Matthew Rain, Allen G. Rodrigo, Daniel Shriner, Shalom Spira, Mario Stevenson, Todd Summers, Catherine Ulich, Joseph P. Vacca, Mark A. Wainberg, Bruce D. Walker, and Yang Wang.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) are genetically and antigenically related viruses with distinct epidemiologic and biologic properties. Since its discovery in West Africa in 1985, various studies have suggested differences between HIV-2 and HIV-1 in geographic distribution, distinct temporal trends in the epidemic spread, and dramatic differences in perinatal and sexual transmission. Studies of HIV-2 infected individuals have shown a significantly slower progression to AIDS. This dramatic difference in pathogenicity provides a unique opportunity to identify viral and host immune mechanisms involved in a closely related virus system that is predicted to have an attenuated phenotype in vivo. This view gave rise to the hypothesis that infection with HIV-2 might provide protection against subsequent infection with the more pathogenic HIV-1. The striking conclusion was that HIV-2 did provide approx. 60% protection against subsequent infection with HIV-1, now evaluated for over 13 years of study. The "natural experiment" of HIV-2's observed protection against HIV-1 infection represents an invaluable model in which important correlates of HIV-1 protection can be identified and characterized. We are hopeful that further comparative studies of these related immunodeficiency viruses will yield important information on the pathogenic mechanisms employed by HIV viruses and lead the way to the development of effective interventions for the prevention and control of the AIDS pandemic.
Author: Gianfranco Pancino
Publisher: Academic Press
ISBN: 0123877156
Category : Medical
Languages : en
Pages : 362
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Book Description
A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field
Author: Thomas J. Hope
Publisher:
ISBN: 9781461496106
Category : AIDS (Disease)
Languages : en
Pages :
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Author:
Publisher:
ISBN: 9788373228573
Category :
Languages : en
Pages : 157
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Author: World Health Organization
Publisher:
ISBN: 9789241549684
Category : AIDS (Disease)
Languages : en
Pages : 429
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Book Description
These guidelines provide guidance on the diagnosis of human immunodeficiency virus (HIV) infection, the use of antiretroviral (ARV) drugs for treating and preventing HIV infection and the care of people living with HIV. They are structured along the continuum of HIV testing, prevention, treatment and care. This edition updates the 2013 consolidated guidelines on the use of antiretroviral drugs following an extensive review of evidence and consultations in mid-2015, shared at the end of 2015, and now published in full in 2016. It is being published in a changing global context for HIV and for health more broadly.
