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Author: Barbara Burtness
Publisher: Springer
ISBN: 3319787624
Category : Medical
Languages : en
Pages : 629
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Book Description
Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.
Author: Barbara Burtness
Publisher: Springer
ISBN: 3319787624
Category : Medical
Languages : en
Pages : 629
Get Book Here
Book Description
Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.
Author: Henning Bier
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805577893
Category : Medical
Languages : en
Pages : 215
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Book Description
The development of head and neck cancer is a multistep process in which genetic as well as epigenetic alterations interfere with the regular functions of proto-oncogenes and tumor suppressor genes. In addition, carcinogenesis is promoted by the impairment of mechanisms responsible for the maintenance of genetic stability. The accumulation of crucial events such as evasion of apoptosis, lack of senescence, deregulated proliferation, invasion and metastasis, as well as neoangiogenesis eventually determines the malignant phenotype. The 16 articles of this volume span from advances in the understanding of underlying molecular pathways (conditional mouse model, folate activity, DNA repair, genomic heterogeneity, p53 family members, human papillomavirus), to preclinical and clinical studies investigating potential novel therapeutic targets (epidermal growth factor receptor, nuclear factor-kappaB, vascular endothelial growth factor, chemokine receptors, P53-based immunotherapy, virus-modified tumor vaccination), and biometric considerations on the evaluation of prognostic factors. This state-of-the-art publication is recommended reading not only for ENT specialists and oncologists, but also for molecular biologists and other subspecialists interested in head and neck cancer research.
Author: Andrew F. Olshan
Publisher: Springer Science & Business Media
ISBN: 1441914722
Category : Medical
Languages : en
Pages : 211
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Book Description
The purpose of this book is to provide a current perspective on the epidemiology head and neck cancer. Cancers of the oral cavity, pharynx, and larynx comprise an important group of tumors with diverse international patterns of incidence and mortality, established risk factors, suggested association with a virus, and potential genetic susceptibility determinants. These tumors offer a unique insight into mechanisms of cancer initiation and progression and gene-exposure interaction.
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher: IARC
ISBN: 9789283212850
Category : Health & Fitness
Languages : en
Pages : 354
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Book Description
A working group of sixteen experts from seven countries re-evaluated the evidence of the carcinogenicity of betel-quid and areca-nut chewing and some areca-nut related nitrosamines. Betel-quid and areca-nut chewing are widely practised in many parts of Asia and in Asian-migrant communities elsewhere in the world. There are hundreds of millions of users worldwide. They evaluated betel quid with tobacco as carcinogenic to humans (Group 1) on the basis of sufficient evidence of an increased risk of cancer of the oral cavity, pharynx and oesophagus. The working group reviewed epidemiological studies of human cancer, mainly studies from India, Pakistan and Taiwan (China). Studies on betel quid with tobacco and areca nut with tobacco in experimental animals now also provide sufficient evidence of carcinogenicity. The working group also evaluated betel quid without tobacco as carcinogenic to humans (Group 1), on the basis of sufficient evidence of an increased risk of oral cancer. Studies on betel quid without tobacco and areca nut without tobacco in experimental animals now also provide sufficient evidence of carcinogenicity. Areca nut, a common ingredient of betel quid and many different chewing preparations, including those available commercially, has been observed to cause oral submucous fibrosis
Author: Bruce Brockstein
Publisher: Springer Science & Business Media
ISBN: 0306480603
Category : Medical
Languages : en
Pages : 380
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Book Description
Exciting advances are occurring in the understanding of the molecular pathogenesis of squamous head and neck cancers. Epidemiology, staging and screening, as well as premalignancy, chemoprevention and the molecular biology of head and neck cancer, lay the groundwork for the understanding of the clinical chapters that follow. Controversial treatments will be compared to the standard management of patient care. Therapy chapters are divided into stage or category specific (resectable advanced, unresectable advanced or metastatic) problems, allowing the reader to review the current standards and options for patient types or specific patients easily. Considerations of supportive care, late toxicities and quality of life, often overlooked are reviewed in detail. This is a comprehensive summary of the current state of the art research and treatment.
Author: Louis B. Harrison
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781771368
Category : Medical
Languages : en
Pages : 1004
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Book Description
This comprehensive, multidisciplinary text addresses all aspects of head and neck cancer and represents a wide spectrum of specialists, including surgical, radiation, and medical oncologists, dentists, pathologists, radiologists, and nurses. The book focuses on a two-part approach to treatment that maximizes the chance for a cure while maintaining a strong emphasis on quality of life. This Third Edition's updated techniques section includes new radiation techniques such as IMRT and IGRT and new endoscopic and laser surgical techniques. Other highlights include a new chapter on reconstructive techniques; significant updates to all site-specific chapters; updates on chemoprevention and molecular targeting; and discussions of new imaging modalities such as fused PET/CT. A companion Website will offer the fully searchable text with all images.
Author: Volkert B. Wreesmann
Publisher:
ISBN:
Category : Chromosome abnormalities
Languages : en
Pages : 516
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Book Description
Academic dissertation for obtaining the degree of doctor by the University of Amsterdam under the authority of Rector Magnificus prof. mr. P.F. van der Heijden in the presence of the regular promotion committee to defend in public in the Auditorium of the University on thursday 2 december 2004, at 10:30 hour with Volkert Boudewijn Wreesmann born in Rotterdam and at 11:30 hours with Bhuvanesh Singh born in Patna (India).
Author: Jacques Bernier
Publisher: Springer
ISBN: 3319276018
Category : Medical
Languages : en
Pages : 877
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Book Description
This second edition provides a comprehensive view of consolidated and innovative concepts, in terms of both diagnosis and treatment. Written by leading international physicians and investigators, this book emphasizes the necessity of combining local and systemic treatments to achieve the objective of yielding higher cure rates and lower toxicities. Heavily updated from the previous edition, it highlights new surgery and radiotherapy techniques, disease awareness, patient quality of life, and comprehensive management. Head-and-neck cancers are a complex clinical entity and their response to treatment is also known to vary markedly in function of host-related factors. Notwithstanding the impressive progresses observed in the field of imaging, head and neck cancers are often diagnosed at a late stage and the presence of locally advanced disease in a significant number of patients implies the use of aggressive treatments in order to both ensure local disease control and reduce distant metastasis risks. In comparison with the first edition, Head and Neck Cancer, Second Edition provides a detailed update of innovative concepts in chemo- and bio-radiation, viral infection impact on tumor growth and response to treatment, and impact of tumor- and host-related factors on treatment outcome.
Author: Andrew F. Olshan
Publisher:
ISBN: 9781441914927
Category :
Languages : en
Pages :
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Book Description
Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer provides a current perspective on the epidemiology of head and neck cancer. Cancers of the oral cavity, pharynx, and larynx comprise an important group of tumors with diverse international patterns of incidence and mortality, established associations with tobacco and alcohol use, the human papilloma virus, and potential determinants of genetic susceptibility. Because of these factors, head and neck cancer offers a unique insight into mechanisms of cancer initiation and progression and gene-exposure interaction. This book brings together the latest epidemiologic and molecular genetic evidence regarding the patterns of occurrence and causes of head and neck cancer. In addition, Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer considers approaches to chemoprevention, and incorporates a multidisciplinary perspective including salient clinical, pathologic, molecular, and epidemiologic contributions.
Author: J.J. Pindborg
Publisher: Springer Science & Business Media
ISBN: 3642605923
Category : Medical
Languages : en
Pages : 115
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Book Description
This book includes more clinical aspects and concentrates on cancer and precancer of the oral mucosa rather than attempting to cover all benign and malignant tumours of the oral and oropharyngeal tissue. One main emphasis is the significance of the clinical features of the various lesions discussed. Attention is also drawn to those conditions particular to the oral mucosa that may give rise to appearances which are important in differential diagnoses but can be misleading to those who do not have detailed knowledge of the tissue involved. The TNM-classification for malignant tumours of the lip and oral cavity is also included.
