Molecular Advances in Dental Pulp Tissue Engineering PDF Download
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Author: Matthias Widbiller
Publisher: Mdpi AG
ISBN: 9783036584768
Category : Science
Languages : en
Pages : 0
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Book Description
The dental pulp, surrounded by the barriers of enamel, dentin and cementum, has several functions. It senses thermal and mechanical stimuli, defends against invading microorganisms and supports root development in young patients. Loss of dental pulp due to caries or trauma requires root canal treatment with synthetic materials. Recent advances in regenerative medicine and tissue engineering aim to restore the dentin-pulp complex using stem cells, growth factors and tailored scaffolds to achieve biological regeneration within the root canal. This Special Issue highlights scientific advances in pulp regeneration, bridging the gap between research and clinical application.
Author: Matthias Widbiller
Publisher: Mdpi AG
ISBN: 9783036584768
Category : Science
Languages : en
Pages : 0
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Book Description
The dental pulp, surrounded by the barriers of enamel, dentin and cementum, has several functions. It senses thermal and mechanical stimuli, defends against invading microorganisms and supports root development in young patients. Loss of dental pulp due to caries or trauma requires root canal treatment with synthetic materials. Recent advances in regenerative medicine and tissue engineering aim to restore the dentin-pulp complex using stem cells, growth factors and tailored scaffolds to achieve biological regeneration within the root canal. This Special Issue highlights scientific advances in pulp regeneration, bridging the gap between research and clinical application.
Author: Ajaykumar Vishwakarma
Publisher: Academic Press
ISBN: 0123977789
Category : Technology & Engineering
Languages : en
Pages : 933
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Book Description
Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translational research in this field in the medical sciences. It compiles basic developmental biology with keen focus on cell and matrix biology, stem cells with relevance to tissue engineering biomaterials including nanotechnology and current applications in various disciplines of dental sciences; viz., periodontology, endodontics, oral & craniofacial surgery, dental implantology, orthodontics & dentofacial orthopedics, organ engineering and transplant medicine. In addition, it covers research ethics, laws and industrial pitfalls that are of particular importance for the future production of tissue constructs. Tissue Engineering is an interdisciplinary field of biomedical research, which combines life, engineering and materials sciences, to progress the maintenance, repair and replacement of diseased and damaged tissues. This ever-emerging area of research applies an understanding of normal tissue physiology to develop novel biomaterial, acellular and cell-based technologies for clinical and non-clinical applications. As evident in numerous medical disciplines, tissue engineering strategies are now being increasingly developed and evaluated as potential routine therapies for oral and craniofacial tissue repair and regeneration. Diligently covers all the aspects related to stem cell biology and tissue engineering in dental sciences: basic science, research, clinical application and commercialization Provides detailed descriptions of new, modern technologies, fabrication techniques employed in the fields of stem cells, biomaterials and tissue engineering research including details of latest advances in nanotechnology Includes a description of stem cell biology with details focused on oral and craniofacial stem cells and their potential research application throughout medicine Print book is available and black and white, and the ebook is in full color
Author: Sibel Yildirim
Publisher: Springer Science & Business Media
ISBN: 1461456878
Category : Science
Languages : en
Pages : 89
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Book Description
Stem cell technology is moving forward at a tremendous rate. Recent discoveries have surprised even the most expert researchers. While every piece of new data broadens the current knowledge and contributes to this moving forward, the new data also serve as paradigm shifters of fundamental knowledge of cell biology. While the question ‘What is a Stem Cell’ may now seem to basic to even discuss, there are still some discrepancies, however, between groups in terms of their functional roles. Teeth develop from the ectoderm of the first branchial arch and the ectomesenchyme of the neural crest. Deciduous teeth start to form between the sixth and eighth weeks, and permanent teeth begin to form in the twentieth weeks. Several studies have demonstrated that the pulp from both adult teeth and deciduous teeth contains dental pulp stem cells. Several factors have made them very attractive as a model system for many researchers; they are multipotent, ethically and non-controversially available in large numbers, immuno-compatible, developmentally primitive, easy to isolate and have high expansion potential in vitro. However, many controversies still exist in the field. There are several unanswered questions in the biology of dental pulp and odontoblasts. This new volume in the SpringerBriefs in Stem Cells series presents an evaluation of stem cells from human dental pulp as a reliable stem cell source for cell-based therapy to stimulate tissue regeneration.
Author: Manasi Bhoj
Publisher: Open Dissertation Press
ISBN: 9781361031803
Category : Medical
Languages : en
Pages : 138
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Book Description
This dissertation, "A Lab-centred Approach for Initiating Early Stage Regeneration of Dental Pulp Using Specialised Alginate Biomimetic Microenvironments" by Manasi, Bhoj, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: A living, self-supporting pulp tissue replacement for patients remains a considerable bioengineering challenge. As yet there is no method for engineering a self-sustaining living pulp tissue that can be successfully transplanted into the patient and have any beneficial clinical outcomes. The main reason for this failure is the inability to reconstitute a functional blood vessel tubular network within the engineered pulp tissue. In addition, it has yet not been possible to engineer the various anatomically distinct structures and architectures of the healthy pulp tissue. The idea is that a bio-engineered pulp-like structure prior to transplantation will accelerate integration and reduce the potential for complications. Recently new strides are being taken to make a functioning living pulp tissue using the latest step by step enhancements that are occurring in biomimetic molecular engineering. The use of this basic tissue engineering processes of living organic matter in fabrication is ensuring that prospective lab-made tissue products are biologically compatible. Systems built into biomaterials involving self-assembly, feedback mechanisms will lead to realistic tissue replicates. The new methods include, fabricating biomimetic tissue frameworks with an array of keystone biochemical cues and structural cues. Alternatively others are suggesting that it is feasible to stimulate natural repair using small molecules and temporary frameworks together or independently. A typical tissue engineering strategy that also promises to work is to combine mixed cell populations and growth factors in a scaffold microenvironment. The hypothesis is that recreating an early stage tissue microenvironment-one that resembles the postnatal constitution that will initiate the autonomous reconstruction of native pulp tissue in vitro. As a result, a coherent self-sustaining and self-supporting tissue construct is prepared for rapid integration and remodeling. Our purpose, in this study is to create the formative elements for pulp tissue that go on to develop and regenerate into a functional living pulp tissue. The objective were firstly, to combine dental mesenchymal stem cells and human umbilical vein endothelial cells with limited key growth factors within a space filling the aalginate hydrogel. Secondly, to test the capacity of these encapsulated stem cells for proliferationon, and lastly, measure the capture level for soluble bio-chemicals and test the capacity of the system to release growth factors in a slow, continuous fashion. These are critical performance issues for building pulp de novo. There are more to be tackled in later stages of developing this technology. An alginate-RGD conjugated gel was used to encapsulate adult dental pulp mesenchymal stem cells and human umbilical vein endothelial cells (HUVEC) in the ratio of 1:1. It also served as a means for the targeted delivery of two key growth factors 〖VEGF〗 DEGREES121 (Vascular endothelial growth factor) and FGF-2 (Fibroblastic growth factor) towards the population of cells. In the experiments we varied the combinations of these four components and results with SEM and confocal microscopy show uniform cell distribution and viable cells in all test and control groups. There were significant differences between the groups with no growth factors and groups in which growth factors were added. Interestingly, c
Author: Vincenzo Guarino
Publisher: CRC Press
ISBN: 042975082X
Category : Medical
Languages : en
Pages : 519
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Book Description
Oral tissue engineering involves the study of current approaches for in vitro regeneration of soft and hard tissues located into the oral cavity. In this context, recent approaches involves the use of innovative biomaterials to replace the lost or damaged human oral tissues. Recent discoveries in materials science and nanotechnology are drastically changing the traditional approach to dentistry by the design of innovative devices able more efficiently supporting the natural regeneration process. The objective of this book is to highlight current progress in tissue engineering for various dental hard/soft tissues including enamel, dentin, pulp, alveolar bone, periodontium, gum and oral mucosa, by emphasizing the role of materials and their specific applications.
Author: Rachel J. Waddington
Publisher: John Wiley & Sons
ISBN: 1118741072
Category : Medical
Languages : en
Pages : 418
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Book Description
Tissue Engineering and Regeneration in Dentistry: Current Strategies presents a thorough update on the current advances, methods and understanding in tissue engineering in dentistry. It offers invaluable tools, case studies, and methodologies for undertaking research, including important biological and practical considerations to facilitate successful migration of research from the bench to the clinic. Offers detailed coverage of the basic underlying principles and scientific evidence, and includes protocols to highlight practical applications Written by an internationally renowned team of expert contributors A must-have read for researchers and specialist clinicians in tissue engineering, oral biology, dental materials science, periodontology and oral surgery
Author: Brent Vernon
Publisher: Elsevier
ISBN: 0857091379
Category : Medical
Languages : en
Pages : 425
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Book Description
Novel injectable materials for non-invasive surgical procedures are becoming increasingly popular. An advantage of these materials include easy deliverability into the body, however the suitability of their mechanical properties must also be carefully considered. Injectable biomaterials covers the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology.Part one focuses on materials and properties, with chapters covering the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites. Part two covers the clinical applications of injectable biomaterials, including chapters on drug delivery, tissue engineering and orthopaedic applications as well as injectable materials for gene delivery systems. In part three, existing and developing technologies are discussed. Chapters in this part cover such topics as environmentally responsive biomaterials, injectable nanotechnology, injectable biodegradable materials and biocompatibility. There are also chapters focusing on troubleshooting and potential future applications of injectable biomaterials.With its distinguished editor and international team of contributors, Injectable biomaterials is a standard reference for materials scientists and researchers working in the biomaterials industry, as well as those with an academic interest in the subject. It will also be beneficial to clinicians. Comprehensively examines the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology Reviews the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites Explores clinical applications of injectable biomaterials, including drug delivery, tissue engineering, orthopaedic applications and injectable materials for gene delivery systems
Author: Rosario Pignatello
Publisher: BoD – Books on Demand
ISBN: 9533076097
Category : Science
Languages : en
Pages : 472
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Book Description
These contribution books collect reviews and original articles from eminent experts working in the interdisciplinary arena of biomaterial development and use. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentials of different synthetic and engineered biomaterials. Contributions were not selected based on a direct market or clinical interest, than on results coming from very fundamental studies which have been mainly gathered for this book. This fact will also allow to gain a more general view of what and how the various biomaterials can do and work for, along with the methodologies necessary to design, develop and characterize them, without the restrictions necessarily imposed by industrial or profit concerns. The book collects 22 chapters related to recent researches on new materials, particularly dealing with their potential and different applications in biomedicine and clinics: from tissue engineering to polymeric scaffolds, from bone mimetic products to prostheses, up to strategies to manage their interaction with living cells.
Author: Douglas Herrera
Publisher: LAP Lambert Academic Publishing
ISBN: 9783659438363
Category :
Languages : en
Pages : 124
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Book Description
The trend for the future of Root Canal Therapy is leaning towards dental pulp tissue regeneration using tissue engineering principles, stem cells, growth factors and scaffolds. Ideally, Root Canal Therapy would involve the removal of diseased pulp tissue and its permanent replacement with healthy pulp to revitalize teeth. Traditionally, during a Root Canal Therapy, the diseased pulp has been removed and replaced by a biocompatible synthetic material. This book presents the concepts and foundations of this new trend. It also presents the results of an in vitro tissue constructs study and the results of pre-clinical trials of dental pulp tissue regeneration in teeth of non-human primates. This study tested the fundamental principles of dental pulp tissue regeneration, as it is now envisioned, using stem cells, growth factors and scaffolds. The aim is to develop a reliable and reproducible protocol that will always give the same result, the revitalization of teeth by the regeneration of dental pulp tissue.
Author: Barbara Zavan
Publisher: Humana Press
ISBN: 3319332996
Category : Science
Languages : en
Pages : 288
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Book Description
This book focuses on the basic aspects of dental stem cells (DSCs) as well as their clinical applications in tissue engineering and regenerative medicine. It opens with a discussion of classification, protocols, and properties of DSCs and proceeds to explore DSCs within the contexts of cryopreservation; epigenetics; pulp, periodontal, tooth, bone, and corneal stroma regeneration; neuronal properties, mesenchymal stem cells and biomaterials; and as sources of hepatocytes for liver disease treatment. The fifteen expertly authored chapters comprehensively examine possible applications of DSCs and provide invaluable insights into mechanisms of growth and differentiation. Dental Stem Cells: Regenerative Potential draws from a wealth of international perspectives and is an essential addition to the developing literature on dental stem cells. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is indispensable for biomedical researchers interested in bioengineering, dentistry, tissue engineering, regenerative medicine, cell biology and oncology.
