Modeling, Design and Synthesis of Parasitic Cysteine Protease Inhibitors PDF Download
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Author: Yogesh A. Sabnis
Publisher:
ISBN:
Category :
Languages : en
Pages : 414
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Book Description
Author: Yogesh A. Sabnis
Publisher:
ISBN:
Category :
Languages : en
Pages : 414
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Book Description
Author: Alejandro Alvarez Hernández
Publisher:
ISBN:
Category :
Languages : en
Pages : 414
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Book Description
Author: Cory D. Emal
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 376
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Book Description
Author: Zhengmao Guo
Publisher:
ISBN:
Category : Cysteine proteinases
Languages : en
Pages : 380
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Book Description
Author: Amy J. Campbell
Publisher:
ISBN: 9781109870527
Category :
Languages : en
Pages : 162
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Book Description
This research involved the design, synthesis, and evaluation of irreversible cysteine protease inhibitors. Specifically, irreversible inhibitors of clan CA and clan CD cysteine proteases were studied. This research offers new and valuable insights into recently developed classes of inhibitors.
Author: Sylvia Shadinger Bridges
Publisher:
ISBN:
Category : Cysteine proteinases
Languages : en
Pages :
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Book Description
Proteases are enzymes that cleave protein amide bonds. Proteases are involved in a myriad of biological processes and are considered good targets for drug design. The proteases described herein are cysteine proteases, which utilize a cysteine residue thiol to attack the amide carbonyl, leading to amide bond cleavage. Irreversible inhibitors of cysteine proteases react with the active site cysteine, forming a covalent bond and rendering the enzyme inactive. The first project involved the design and synthesis of aza-peptide epoxide inhibitors for calpain, a clan CA, ubiquitous, calcium-activated human enzyme involved in neurodegeneration. These inhibitors proved to be poor inactivators of calpain, demonstrating that the aza-peptide epoxide is a warhead specific to clan CD cysteine proteases (caspases, gingipains). Subsequently, a known epoxide inhibitor of calpain was optimized to create a more potent inhibitor. Several of these inhibitors were more potent than the parent, and all were demonstrated to inhibit calpain in a breast cancer cell line which was treated with paclitaxel to spike calpain activity.
Author: Koen Steert
Publisher:
ISBN:
Category :
Languages : en
Pages : 228
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Book Description
Author: Karen Amanda Ellis James
Publisher:
ISBN:
Category : Crysteine proteinase
Languages : en
Pages : 324
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Book Description
Author: Roger Hull
Publisher: Academic Press
ISBN: 0123848725
Category : Science
Languages : en
Pages : 1119
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Book Description
The seminal text Plant Virology is now in its fifth edition. It has been 10 years since the publication of the fourth edition, during which there has been an explosion of conceptual and factual advances. The fifth edition of Plant Virology updates and revises many details of the previous edition while retaining the important earlier results that constitute the field's conceptual foundation. Revamped art, along with fully updated references and increased focus on molecular biology, transgenic resistance, aphid transmission, and new, cutting-edge topics, bring the volume up to date and maintain its value as an essential reference for researchers and students in the field. - Thumbnail sketches of each genera and family groups - Genome maps of all genera for which they are known - Genetic engineered resistance strategies for virus disease control - Latest understanding of virus interactions with plants, including gene silencing - Interactions between viruses and insect, fungal, and nematode vectors - Contains over 300 full-color illustrations
Author: Mark W. Robinson
Publisher: Springer Science & Business Media
ISBN: 1441984143
Category : Medical
Languages : en
Pages : 243
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Book Description
Cysteine proteases expressed by pathogenic organisms play key roles in virulence including host entry, feeding and suppression of host immune responses. This book gives comprehensive coverage to all aspects of pathogen cysteine proteases and brings together numerous scientific advances which have been made over many years. Thus, the biochemistry, molecular biology and structure‐function relationships of these important pathogen enzymes are covered in detail. Written by leading researchers from Europe, Australia and North America, this book is essential reading for students and professionals interested in human medicine and infectious disease research.
