Microfabricated Parylene Microneedles and Pneumatic/hydraulic Actuators for Use in Interventional, Transvascular Drug Delivery PDF Download
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Author: Kirk Patrick Seward
Publisher:
ISBN:
Category :
Languages : en
Pages : 254
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Book Description
Author: Kirk Patrick Seward
Publisher:
ISBN:
Category :
Languages : en
Pages : 254
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Book Description
Author: Eric David Hobbs
Publisher:
ISBN:
Category :
Languages : en
Pages : 506
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Book Description
Author: Elliot En-Yu Hui
Publisher:
ISBN:
Category :
Languages : en
Pages : 274
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Book Description
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 734
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Book Description
Author: Jaspreet Singh Kochhar
Publisher: Springer
ISBN: 3030154440
Category : Medical
Languages : en
Pages : 163
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Book Description
This monograph covers a novel technology to deliver drugs and cosmetics through the skin in a minimally invasive manner. Microneedles – a bed of miniaturized needles is one of the most studied topics in delivering actives through the skin barrier. This book enables readers to understand the delivery of ingredients through the skin, describes a novel and simple method to fabricate microneedles containing a range of small and large molecular weight compounds, studies their physical properties as well as delivery through the skin layers. Readers will discover this book to be extremely beneficial to help them understand the state of the field of transdermal drug delivery, with extensive coverage including experimental data on basics of microneedle fabrication technology using photolithography, encapsulation of drugs within the polymeric matrix of microneedles and studying their release patternsin vitro and ex vivo . Academic researchers, pharmaceutical and cosmeceutical industry as well as students of skin science will find this account very useful in their pursuits. As microneedles grow and develop into a commercial reality with more actives being delivered and significant clinical research being put in, this account will hold well in providing basic principles and knowledge together with rigorous experimental data.
Author: Jingjiao Guan
Publisher:
ISBN:
Category : Drug delivery systems
Languages : en
Pages :
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Book Description
Abstract: Microfabrication technology, with many technologies originally developed for producing computer chips, is being used to fabricate particulate drug delivery microdevices with uniform dimensions, well-defined and asymmetrical structures, multiple components, and multiple functions. For this application, conventional silicon-based microfabrication techniques have some drawbacks, such as the use of expensive cleanroom-based facilities and limited ability for processing polymers. In this dissertation, polymer-based microfabrication technology, in particular soft lithography, is used to produce particulate polymeric microstructures for drug delivery. Plate-like particulate polymeric microstructures made of various biomedical polymers with different sizes and shapes have been created. They may be used as drug-carrying vehicles in a number of applications such as ocular drug delivery. Microstructures with single reservoir have been produced by polymerizing liquid resin filled in ring-shaped recessed microfeatures. Microstructures containing multiple reservoirs have also been fabricated by combining polymer printing and embossing. These reservoir-containing microstructures may be used for oral delivery or macromolecular drugs. Capsule-like microstructures with model drug encapsulated by a biodegradable polymer have been fabricated. This type of microstructures may be used as injectable system for sustained drug delivery. By combining two polymer layers with different swelling ratios together, we have produced self-foldable microstructures that may be used as a novel strategy to enhance mucoadhsion and drug permeation in transmucosal drug delivery. In conclusion, the polymeric microstructures produced in this dissertation have potential to be used in a variety of drug delivery applications and polymer-based microfabrication technology hold promise to produce the highly engineered, multi-functional, and "intelligent" next generation drug delivery microdevices.
