Nano- and Microfabrication Techniques in Drug Delivery PDF Download
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Author: Dimitrios Lamprou
Publisher: Springer Nature
ISBN: 303126908X
Category : Science
Languages : en
Pages : 499
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Book Description
New materials and manufacturing techniques are evolving with the potential to address the challenges associated with the manufacture of medicinal products that will teach new tricks to old drugs. Nano- and microfabrication techniques include manufacturing methods such as additive manufacturing, lithography, micro-moulding, spray drying, and supercritical fluids among many others. The increasing resolution of new techniques allow researchers to produce objects with micrometric resolutions. This book follows a consecutive order, beginning with a background in the current field and limitations in the manufacturing of different pharmaceutical products, moving on the classification of each method by providing recent examples, and future prospective on a variety of traditional and new Nano and microfabrication techniques. A focus on the materials used to prepare these systems and their biocompatibility, including applied topics such as clinical applications and regulatory aspects also covered, offering the reader a holistic view of this rapidly growing field.
Author: Dimitrios Lamprou
Publisher: Springer Nature
ISBN: 303126908X
Category : Science
Languages : en
Pages : 499
Get Book Here
Book Description
New materials and manufacturing techniques are evolving with the potential to address the challenges associated with the manufacture of medicinal products that will teach new tricks to old drugs. Nano- and microfabrication techniques include manufacturing methods such as additive manufacturing, lithography, micro-moulding, spray drying, and supercritical fluids among many others. The increasing resolution of new techniques allow researchers to produce objects with micrometric resolutions. This book follows a consecutive order, beginning with a background in the current field and limitations in the manufacturing of different pharmaceutical products, moving on the classification of each method by providing recent examples, and future prospective on a variety of traditional and new Nano and microfabrication techniques. A focus on the materials used to prepare these systems and their biocompatibility, including applied topics such as clinical applications and regulatory aspects also covered, offering the reader a holistic view of this rapidly growing field.
Author: Jingjiao Guan
Publisher:
ISBN:
Category : Drug delivery systems
Languages : en
Pages :
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Book Description
Abstract: Microfabrication technology, with many technologies originally developed for producing computer chips, is being used to fabricate particulate drug delivery microdevices with uniform dimensions, well-defined and asymmetrical structures, multiple components, and multiple functions. For this application, conventional silicon-based microfabrication techniques have some drawbacks, such as the use of expensive cleanroom-based facilities and limited ability for processing polymers. In this dissertation, polymer-based microfabrication technology, in particular soft lithography, is used to produce particulate polymeric microstructures for drug delivery. Plate-like particulate polymeric microstructures made of various biomedical polymers with different sizes and shapes have been created. They may be used as drug-carrying vehicles in a number of applications such as ocular drug delivery. Microstructures with single reservoir have been produced by polymerizing liquid resin filled in ring-shaped recessed microfeatures. Microstructures containing multiple reservoirs have also been fabricated by combining polymer printing and embossing. These reservoir-containing microstructures may be used for oral delivery or macromolecular drugs. Capsule-like microstructures with model drug encapsulated by a biodegradable polymer have been fabricated. This type of microstructures may be used as injectable system for sustained drug delivery. By combining two polymer layers with different swelling ratios together, we have produced self-foldable microstructures that may be used as a novel strategy to enhance mucoadhsion and drug permeation in transmucosal drug delivery. In conclusion, the polymeric microstructures produced in this dissertation have potential to be used in a variety of drug delivery applications and polymer-based microfabrication technology hold promise to produce the highly engineered, multi-functional, and "intelligent" next generation drug delivery microdevices.
Author: Mark J. Schulz
Publisher: Artech House
ISBN: 1596932805
Category : Medical
Languages : en
Pages : 549
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Book Description
Annotation This resource outlines the new tools that are becoming available in nanomedicine. The book presents an integrated set of perspectives that describe where advancements are now and where they should be headed to put nanomedicine devices into applications as quickly as possible
Author: Savas Tasoglu
Publisher: MDPI
ISBN: 3038974676
Category : Technology & Engineering
Languages : en
Pages : 213
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Book Description
This book is a printed edition of the Special Issue "3D Printed Microfluidic Devices" that was published in Micromachines
Author: Mansoor M. Amiji
Publisher: CRC Press
ISBN: 0203500474
Category : Medical
Languages : en
Pages : 707
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Book Description
To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle must be able to deliver genes to the appropriate tissues and cells in the body in a specific as well as safe and effective manner. While viruses are the most popular vehicles to date, their disadvantages include toxicity, limited size of genes they can carry
Author: Jeremy C. Wright
Publisher: Springer Science & Business Media
ISBN: 1461405548
Category : Medical
Languages : en
Pages : 556
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Book Description
Long acting injections and implants improve therapy, enhance patient compliance, improve dosing convenience, and are the most appropriate formulation choice for drugs that undergo extensive first pass metabolism or that exhibit poor oral bioavailability. An intriguing variety of technologies have been developed to provide long acting injections and implants. Many considerations need to go into the design of these systems in order to translate a concept from the lab bench to actual therapy for a patient. This book surveys and summarizes the field. Topics covered in Long Acting Injections and Implants include the historical development of the field, drugs, diseases and clinical applications for long acting injections and implants, anatomy and physiology for these systems, specific injectable technologies (including lipophilic solutions, aqueous suspensions, microspheres, liposomes, in situ forming depots and self-assembling lipid formulations), specific implantable technologies (including osmotic implants, drug eluting stents and microfabricated systems), peptide, protein and vaccine delivery, sterilization, drug release testing and regulatory aspects of long acting injections and implants. This volume provides essential information for experienced development professionals but was also written to be useful for scientists just beginning work in the field and for others who need an understanding of long acting injections and implants. This book will also be ideal as a graduate textbook.
Author: João Pedro Martins
Publisher: Academic Press
ISBN: 0128180390
Category : Medical
Languages : en
Pages : 536
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Book Description
Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery systems, and highlighting the challenges of improving intestinal permeability and drug absorption. Oral delivery is the most widely used form of drug administration due to ease of ingestion, cost effectiveness, and versatility, by allowing for the accommodation of different types of drugs, having the highest patient compliance. In this book, a comprehensive overview of the most promising and up-to-date engineered and surface functionalized drug carrier systems, as well as opportunities for the development of novel and robust delivery platforms for oral drug administration are discussed. The relevance of controlling the physicochemical properties of the developed particle formulations, from size and shape to drug release profile are broadly reviewed. Advances in both in vitro and in vivo scenarios are discussed, focusing on the possibilities to study the biological-material interface. The industrial perspective on the production of nanotechnology-based oral drug delivery systems is also covered. Nanotechnology for Oral Drug Delivery: From Concept to Applications is essential reading for researchers, professors, advanced students and industry professionals working in the development, manufacturing and/or commercialization of nanotechnology-based systems for oral drug delivery, targeted drug delivery, controlled drug release, materials science and biomaterials, in vitro and in vivo testing of potential oral drug delivery technologies. - Highlights the relevance of oral drug delivery in the clinical setting - Covers the most recent advances in the field of nanotechnology for oral drug delivery - Provides the scientific community with data that can facilitate and guide their research
Author: Jaspreet Singh Kochhar
Publisher: Springer
ISBN: 3030154440
Category : Medical
Languages : en
Pages : 163
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Book Description
This monograph covers a novel technology to deliver drugs and cosmetics through the skin in a minimally invasive manner. Microneedles – a bed of miniaturized needles is one of the most studied topics in delivering actives through the skin barrier. This book enables readers to understand the delivery of ingredients through the skin, describes a novel and simple method to fabricate microneedles containing a range of small and large molecular weight compounds, studies their physical properties as well as delivery through the skin layers. Readers will discover this book to be extremely beneficial to help them understand the state of the field of transdermal drug delivery, with extensive coverage including experimental data on basics of microneedle fabrication technology using photolithography, encapsulation of drugs within the polymeric matrix of microneedles and studying their release patternsin vitro and ex vivo . Academic researchers, pharmaceutical and cosmeceutical industry as well as students of skin science will find this account very useful in their pursuits. As microneedles grow and develop into a commercial reality with more actives being delivered and significant clinical research being put in, this account will hold well in providing basic principles and knowledge together with rigorous experimental data.
Author: Chris Van Der Walle
Publisher: Academic Press
ISBN: 0123849365
Category : Science
Languages : en
Pages : 381
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Book Description
The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. - Discusses the most recent data, ideas and concepts - Presents case studies and an industrial perspective - Details information from the molecular level to bioprocessing - Thought provoking, for the novice to the specialist - Timely, for today's biopharmaceuticals market
Author: Hélder A. Santos
Publisher: William Andrew
ISBN: 9780128126592
Category : Science
Languages : en
Pages : 0
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Book Description
Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery is a concept-orientated reference that features case studies on utilizing microfluidics for drug delivery applications. It is a valuable learning reference on microfluidics for drug delivery applications and assists practitioners developing novel drug delivery platforms using microfluidics. It explores advances in microfluidics for drug delivery applications from different perspectives, covering device fabrication, fluid dynamics, cutting-edge microfluidic technology in the global drug delivery industry, lab-on-chip nano/micro fabrication and drug encapsulation, cell encapsulation and delivery, and cell- drug interaction screening. These microfluidic platforms have revolutionized the drug delivery field, but also show great potential for industrial applications.
